Results 261 to 270 of about 62,138 (272)
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Homologs of Small Nucleolar RNAs in Archaea
Science, 2000In eukaryotes, dozens of posttranscriptional modifications are directed to specific nucleotides in ribosomal RNAs (rRNAs) by small nucleolar RNAs (snoRNAs). We identified homologs of snoRNA genes in both branches of the Archaea. Eighteen small sno-like RNAs (sRNAs) were cloned from the archaeon Sulfolobus acidocaldarius
A D, Omer +5 more
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The many faces of small nucleolar RNAs
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2014Small nucleolar RNAs (snoRNAs) are a class of evolutionally conserved non-coding RNAs traditionally associated with nucleotide modifications in other RNA species. Acting as guides pairing with ribosomal (rRNA) and small nuclear RNAs (snRNAs), snoRNAs direct partner enzymes to specific sites for uridine isomerization or ribose methylation, thereby ...
Tomaž Bratkovič, Boris Rogelj
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Small Nucleolar RNA Expression Profiling in Cartilage
2020Osteoarthritis (OA) presents as a change in the articular chondrocyte phenotype. The origin of the phenotype change is poorly understood. Small nucleolar RNAs (snoRNAs) direct chemical modification of other RNA substrates and are involved in endoribonucleolytic pre-rRNA processing.
Peffers, Mandy J +2 more
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Small nucleolar RNAs and RNA-guided post-transcriptional modification
Essays in Biochemistry, 2013snoRNAs (small nucleolar RNAs) constitute one of the largest and best-studied classes of non-coding RNAs that confer enzymatic specificity. With associated proteins, these snoRNAs form ribonucleoprotein complexes that can direct 2′-O-methylation or pseudouridylation of target non-coding RNAs.
Lauren, Lui, Todd, Lowe
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Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
Nature Reviews Molecular Cell Biology, 2007Recent advances have fuelled rapid growth in our appreciation of the tremendous number, diversity and biological importance of non-coding (nc)RNAs. Because ncRNAs typically function as ribonucleoprotein (RNP) complexes and not as naked RNAs, understanding their biogenesis is crucial to comprehending their regulation and function.
A Gregory, Matera +2 more
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Expression of small nucleolar RNAs in leukemic cells
Cellular Oncology, 2012Small nucleolar RNAs (snoRNAs) direct sequence-specific modifications to ribosomal RNA. We hypothesized that the expression of snoRNAs may be altered in leukemic cells.The expression of snoRNAs was analyzed in various leukemic cell lines by massive parallel sequencing (SOLiD).
Uusimäki Annemari +6 more
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Probing RNA in Vivo with Methylation Guide Small Nucleolar RNAs
Methods, 2001Most box C/D small nucleolar RNAs (snoRNAs) direct the formation of 2'-O-methylated nucleotides in ribosomal RNA and, apparently, other RNAs present in the nucleolar complex. Sites to be modified are selected by a long (>10-nt) antisense guide sequence in the snoRNA and a distance measurement from a box D or D' element that follows the snoRNA guide ...
B, Liu, J, Ni, M J, Fournier
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Deep Sequencing Analysis of Nucleolar Small RNAs: Bioinformatics
2016Small RNAs (size 20-30 nt) of various types have been actively investigated in recent years, and their subcellular compartmentalization and relative concentrations are likely to be of importance to their cellular and physiological functions. Comprehensive data on this subset of the transcriptome can only be obtained by application of high-throughput ...
Baoyan, Bai, Marikki, Laiho
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Implications of Small Nucleolar RNA-Protein Complexes Discoveries
Recent Patents on DNA & Gene Sequences, 2008Small nucleolar RNA molecules (snoRNA) comprise a special kind of non-coding RNAs involved in the maturation process of rRNAs, snRNAs, tRNAs and mRNAs. Traditionally, these molecules have been divided into two families depending on the type of conserved boxes that they harbour: box C/D and H/ACA snoRNAs.
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