Results 21 to 30 of about 202,981 (234)

The C/D box small nucleolar RNA SNORD52 regulated by Upf1 facilitates Hepatocarcinogenesis by stabilizing CDK1

Theranostics, 2020
Rationale: Understanding the roles of small nucleolar RNAs (snoRNAs) in hepatocarcinogenesis will provide new avenues to identify diagnostic and therapeutic targets for hepatocellular carcinoma (HCC). Our previous research confirmed the tumor-suppressive
Cuicui Li, Long Wu, Pengpeng Liu, Kun Li, Zhongling Zhang, Yue-ming He, Quanyan Liu, Ping Jiang, Zhiyong Yang, Zhisu Liu, Yufeng Yuan, Lei Chang   +11 more
semanticscholar   +1 more source

Integrated analysis reveals a potential cuproptosis-related ceRNA axis SNHG17/miR-29a-3p/GCSH in prostate adenocarcinoma

Heliyon, 2023
Cuproptosis is a novel form of programmed cell death. The role and mechanism of cuproptosis-related genes in prostate adenocarcinoma have not been fully understood. In this study, a series of bioinformatic analyses were performed.
Shuyuan Xiao, Weiyang Lou
doaj   +1 more source

LncRNA-LALR1 upregulates small nucleolar RNA SNORD72 to promote growth and invasion of hepatocellular carcinoma

Aging, 2020
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers and currently the second leading cause of cancer-related mortality worldwide. One recent study reported that lncRNA-LALR1 promotes liver regeneration, the role and underlying mechanisms ...
Lin-hong Mao, Sisi Chen, Xiao-qin Li, Feng Xu, Jing Lei, Qing-liang Wang, Li Luo, Haiyan Cao, Xin Ge, T. Ran, Xue Li, M. Zou, Zhihang Zhou, Xiao-ling Wu, Song He   +14 more
semanticscholar   +1 more source

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

eLife, 2019
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA).
M. McMahon, Adrián Contreras, M. Holm, Tamayo Uechi, Craig M. Forester, Xiaming Pang, Cody Jackson, Meredith E K Calvert, Bin Chen, D. Quigley, J. Luk, R. Kelley, J. Gordan, R. Gill, S. Blanchard, D. Ruggero   +15 more
semanticscholar   +1 more source

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

Acta Neuropathologica Communications, 2017
An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and
Sarah Mizielinska, Charlotte E. Ridler, Rubika Balendra, Annora Thoeng, Nathan S. Woodling, Friedrich A. Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M. Isaacs   +9 more
doaj   +1 more source

Expression scoring of a small‐nucleolar‐RNA signature identified by machine learning serves as a prognostic predictor for head and neck cancer

Journal of Cellular Physiology, 2020
Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with high mortality and poor prognosis due to a lack of predictive markers. Increasing evidence has demonstrated small nucleolar RNAs (snoRNAs) play an important role in tumorigenesis ...
L. Xing, Xiaoqi Zhang, Xiaoqian Zhang, Dongdong Tong   +3 more
semanticscholar   +1 more source

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs

FEBS Open Bio, 2014
Micro RNAs (miRNA) are non-coding RNAs expressed in the cytoplasm as their mature, 21–22-nucleotide short forms. More recently, mature miRNAs have also been detected in the nucleus, raising the possibility that their spatial distribution may be more ...
Baoyan Bai, Hester Liu, Marikki Laiho
doaj   +1 more source

Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors

Nature Communications, 2022
Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine ...
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa   +17 more
doaj   +1 more source

Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis

Frontiers in Molecular Biosciences, 2023
Introduction: The anterior cruciate ligament (ACL) is susceptible to degeneration, resulting in joint pain, reduced mobility, and osteoarthritis development.
Yalda A. Kharaz, Danae E. Zamboulis, Yongxiang Fang, Tim J. M. Welting, Mandy J. Peffers, Eithne J. Comerford, Eithne J. Comerford   +6 more
doaj   +1 more source

Upregulation of Long Non-Coding RNA Small Nucleolar RNA Host Gene 12 Contributes to Cell Growth and Invasion in Cervical Cancer by Acting as a Sponge for MiR-424-5p

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cervical cancer, which is one of the most aggressive cancers affecting females, has high rates of recurrence and mortality. Small nucleolar RNA host gene 12 (SNHG12) is known to promote the progression of several cancers; however, its ...
Jing Dong, Qing Wang, Li Li, Xiao-jin Zhang   +3 more
semanticscholar   +1 more source