Results 41 to 50 of about 442,180 (329)
Small Nucleolar RNAs: Insight Into Their Function in Cancer [PDF]
Frontiers in Oncology, 2019 Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes: C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA box snoRNAs are 2'-O-ribose methylation and pseudouridylation of ribosomal RNAs (rRNAs), respectively.
Zhao Huang +5 more
openaire +4 more sources
Expression profiling of snoRNAs in normal hematopoiesis and AML [PDF]
, 2018 Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in ...
Helton, Nichole +6 more
core +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Cervical cancer, which is one of the most aggressive cancers affecting females, has high rates of recurrence and mortality. Small nucleolar RNA host gene 12 (SNHG12) is known to promote the progression of several cancers; however, its ...
Jing Dong +3 more
semanticscholar +1 more source
Journal of Cellular Physiology, 2020 Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with high mortality and poor prognosis due to a lack of predictive markers. Increasing evidence has demonstrated small nucleolar RNAs (snoRNAs) play an important role in tumorigenesis ...
L. Xing +3 more
semanticscholar +1 more source
Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing [PDF]
, 2002 Many analyses have examined subnucleolar structures in eukaryotic cells, but the relationship between morphological structures, pre-rRNA processing, and ribosomal particle assembly has remained unclear.
Gadal, O +6 more
core +2 more sources
FEBS Open Bio, 2014 Micro RNAs (miRNA) are non-coding RNAs expressed in the cytoplasm as their mature, 21–22-nucleotide short forms. More recently, mature miRNAs have also been detected in the nucleus, raising the possibility that their spatial distribution may be more ...
Baoyan Bai, Hester Liu, Marikki Laiho
doaj +1 more source
Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
Nature Communications, 2022 Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine ...
Melvin Pan +17 more
doaj +1 more source
Structure of a rare non-standard sequence k-turn bound by L7Ae protein [PDF]
, 2014 Kt-23 from Thelohania solenopsae is a rare RNA kink turn (k-turn) where an adenine replaces the normal guanine at the 2n position. L7Ae is a member of a strongly conserved family of proteins that bind a range of k-turn structures in the ribosome, box C/D
Huang, Lin, Lilley, David M J
core +2 more sources
Small Nucleolar RNAs Tell a Different Tale [PDF]
Trends in Genetics, 2019 Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase complex employs entirely different strategies, which usually direct the nascent transcript to ribonucleolytic degradation.
Kufel, Joanna, Grzechnik, Pawel
openaire +3 more sources
Expression and Functional Studies on the Noncoding RNA, PRINS. [PDF]
, 2012 PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated
Amin +61 more
core +2 more sources