Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation
Biology Open, 2018 Ribosomes can be heterogeneous, and the major contributor to ribosome heterogeneity is variation in rRNA modification. There are two major types of rRNA modification, pseudouridylation and ribose methylation.
Marilyn F. Burke +2 more
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Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
Nature Communications, 2021 Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects ...
Arthur C. Sletten +13 more
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Diverse human extracellular RNAs are widely detected in human plasma
Nature Communications, 2016 Extracellular miRNAs are present in a variety of bodily fluids. Here, Freedman et al. analysed plasma-derived RNA by RNA-seq from 40 people followed by targeted RT-qPCR in an additional 2,763 people, and report over 1,000 extracellular RNAs including ...
Jane E. Freedman +19 more
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Molecular determinants that govern scaRNA processing by Drosha/DGCR8
Biology Open, 2020 The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase.
Douglas M. McLaurin +3 more
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LncRNA SNHG1: role in tumorigenesis of multiple human cancers
Cancer Cell International, 2023 Small nucleolar RNA host gene 1 (SNHG1) is an important member of the SNHG family. This family is composed of a group of host genes that can be processed into small nucleolar RNAs and play important biological functions.
Huang Zeng +4 more
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SnoRNA and lncSNHG: Advances of nucleolar small RNA host gene transcripts in anti-tumor immunity
Frontiers in Immunology, 2023 The small nucleolar RNA host genes (SNHGs) are a group of genes that can be transcript into long non-coding RNA SNHG (lncSNHG) and further processed into small nucleolar RNAs (snoRNAs).
Hao Xiao +9 more
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Evolution of Fungal U3 snoRNAs: Structural Variation and Introns
Non-Coding RNA, 2017 The U3 small nucleolar RNA (snoRNA) is an essential player in the initial steps of ribosomal RNA biogenesis which is ubiquitously present in Eukarya.
Sebastian Canzler +2 more
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RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs. [PDF]
PLoS ONE, 2014 Small non-coding RNAs represent RNA species that are not translated to proteins, but which have diverse and broad functional activities in physiological and pathophysiological states. The knowledge of these small RNAs is rapidly expanding in part through
Baoyan Bai +3 more
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The genetic and pharmacogenomic landscape of snoRNAs in human cancer
Molecular Cancer, 2020 Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized.
Yaoming Liu +10 more
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A high-throughput assay for directly monitoring nucleolar rRNA biogenesis
Open Biology, 2022 Studies of the regulation of nucleolar function are critical for ascertaining clearer insights into the basic biological underpinnings of ribosome biogenesis (RB), and for future development of therapeutics to treat cancer and ribosomopathies.
Carson J. Bryant +4 more
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