Results 41 to 50 of about 202,981 (234)
Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
Nature Communications, 2021 Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects ...
Arthur C. Sletten +13 more
doaj +1 more source
Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
npj Breast Cancer, 2017 RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells.
Dillon G. Patterson +23 more
doaj +1 more source
A high-throughput assay for directly monitoring nucleolar rRNA biogenesis
Open Biology, 2022 Studies of the regulation of nucleolar function are critical for ascertaining clearer insights into the basic biological underpinnings of ribosome biogenesis (RB), and for future development of therapeutics to treat cancer and ribosomopathies.
Carson J. Bryant +4 more
doaj +1 more source
Diverse human extracellular RNAs are widely detected in human plasma
Nature Communications, 2016 Extracellular miRNAs are present in a variety of bodily fluids. Here, Freedman et al. analysed plasma-derived RNA by RNA-seq from 40 people followed by targeted RT-qPCR in an additional 2,763 people, and report over 1,000 extracellular RNAs including ...
Jane E. Freedman +19 more
doaj +1 more source
Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation
Biology Open, 2018 Ribosomes can be heterogeneous, and the major contributor to ribosome heterogeneity is variation in rRNA modification. There are two major types of rRNA modification, pseudouridylation and ribose methylation.
Marilyn F. Burke +2 more
doaj +1 more source
Molecular determinants that govern scaRNA processing by Drosha/DGCR8
Biology Open, 2020 The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase.
Douglas M. McLaurin +3 more
doaj +1 more source
Evolution of Fungal U3 snoRNAs: Structural Variation and Introns
Non-Coding RNA, 2017 The U3 small nucleolar RNA (snoRNA) is an essential player in the initial steps of ribosomal RNA biogenesis which is ubiquitously present in Eukarya.
Sebastian Canzler +2 more
doaj +1 more source
LncRNA SNHG1: role in tumorigenesis of multiple human cancers
Cancer Cell International, 2023 Small nucleolar RNA host gene 1 (SNHG1) is an important member of the SNHG family. This family is composed of a group of host genes that can be processed into small nucleolar RNAs and play important biological functions.
Huang Zeng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2016 Pan Zhu +6 more
openalex +2 more sources