Results 41 to 50 of about 62,138 (272)

Fluorescent protein tagging confirms the presence of ribosomal proteins atDrosophilapolytene chromosomes [PDF]

, 2013
\ud \ud Most ribosomal proteins (RPs) are stoichiometrically incorporated into ribosomal subunits and play essential roles in ribosome biogenesis and function.
Bischof, Bohnsack, Brogna, Coleno-Costes, Dai, Dai, De, De, Freeman, Gavin, Gerlitz, Hurt, Inada, Johansen, Jurica, Klinge, Kondrashov, Lam, Lee, Malygin, Marygold, Ni, Ramanathan, Shi, Shopland, Steitz, Warner, Zhimulev   +27 more
core   +3 more sources

On the nucleolar size and density in human early granulocytic progenitors, myeloblasts

European Journal of Histochemistry, 2009
Human myeloblasts were studied in bone marrow of patients suffering from chronic phase of chronic myeloid leukaemia to provide more information on the nucleolar diameter in these early granulocytic progenitors. These cells are a convenient model for such
K Smetana, H Klamová, D Mikulenková, M Pluskalová, Z Hrkal   +4 more
doaj   +1 more source

Targeted knock-down of miR21 primary transcripts using snoMEN vectors induces apoptosis in human cancer cell lines [PDF]

, 2015
We have previously reported an antisense technology, 'snoMEN vectors', for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use
A Kozomara, A Rodriguez, AG Matera, AK Leung, AM Burroughs, AM Cheng, Angus I. Lamond, B Bai, C Ender, Christophe Antoniewski, CL Ahlenstiel, D De Paula, D Iliopoulos, Dalila Bensaddek, EC Lai, EC Lai, EJ Chapman, EJ Jung, Fabio Avolio, FJ Sheedy, FM Boisvert, FM Boisvert, G Reimer, GS Pall, I Rebbapragada, J Elmen, J Krutzfeldt, J Liu, J Weischenfeldt, JC Politz, JS Andersen, JS Andersen, K Yamada, Kayo Yamada, KK Farh, L Agranat, L Trinkle-Mulcahy, LB Frankel, LB Weinstein, M Negrini, M Ono, M Ono, M Ono, M Scherr, ME Hatley, Motoharu Ono, MS Scott, MS Scott, N Bushati, O Isken, RS Coffin, S Baskerville, S Griffiths-Jones, SD Selcuklu, T Kiss, Vackar Afzal, Y Ahmad, YK Kim, YS Lee, YW Lam   +59 more
core   +5 more sources

Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Nature Communications, 2020
Small non-coding RNAs contribute to the regulation of aging. Here the authors identify a small nucleolar RNA, the snoRNA jouvence, which extends the lifespan of fruit flies through its function in the gut, and is conserved in humans.
Stéphanie Soulé, Lucille Mellottée, Abdelkrim Arab, Chongjian Chen, Jean-René Martin   +4 more
doaj   +1 more source

Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes [PDF]

, 2019
Type 1 diabetes (T1D) is characterized by the immune-mediated destruction of insulin-producing islet β cells. Biomarkers capable of identifying T1D risk and dissecting disease-related heterogeneity represent an unmet clinical need.
Evans-Molina, Carmella, G. Mirmira, Raghavendra, Jiyun Kang, Nicole, Krishnan, Preethi, Syed, Farooq   +4 more
core   +2 more sources

Evolution of small nucleolar RNAs in nematodes [PDF]

Nucleic Acids Research, 2006
In contrast to mRNAs, which are templates for translating proteins, non-protein coding (npc) RNAs (also known as 'non-coding' RNA, ncRNA), exhibit various functions in different compartments and developmental stages of the cell. Small nucleolar RNAs (snoRNAs), one of the largest classes of npcRNAs, guide post-transcriptional modifications of other RNAs
Zemann, Anja, op de Bekke, Anja, Kiefmann, Martin, Brosius, Jürgen, Schmitz, Jürgen   +4 more
openaire   +2 more sources

A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]

, 2017
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun, Guo, Yibin, Huang, Chunliu, Huang, Shanshan, Huang, Weijun, Huang, Xi, Jia, Jie, Ming, Siqi, Shi, Junjie, Shi, Yongsheng, Wu, Xingui, Xiang, Andy Peng, Yao, Chengguo, Zhang, Rui, Zhao, Wei   +14 more
core   +1 more source

LncRNA SNHG15 contributes to doxorubicin resistance of osteosarcoma cells through targeting the miR-381-3p/GFRA1 axis

Open Life Sciences, 2020
Osteosarcoma is a common primary malignant bone cancer. Long noncoding RNA small nucleolar RNA host gene 15 (SNHG15) has been reported to play an oncogenic role in many cancers.
Zhang Jinshan, Rao Dan, Ma Haibo, Kong Defeng, Xu Xiaoming, Lu Hougen   +5 more
doaj   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization [PDF]

, 1969
The disappearance of nucleolus has been traced in the rat erythroid cells in relation with the cell specialization under varying conditions, i. e. in anemia with or without treatment by bromouracil and aminopterin.
Shigehisa, Morio
core   +1 more source

Small Nucleolar RNAs Tell a Different Tale [PDF]

Trends in Genetics, 2019
Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase complex employs entirely different strategies, which usually direct the nascent transcript to ribonucleolytic degradation.
Kufel, Joanna, Grzechnik, Pawel
openaire   +3 more sources