Results 71 to 80 of about 62,138 (272)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Functional diversity of small nucleolar RNAs

Nucleic Acids Research, 2019
AbstractSmall nucleolar RNAs (snoRNAs) are short non-protein-coding RNAs with a long-recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation and pseudouridylation at targeted nucleotide residues of ribosomal and small nuclear RNAs, respectively.
Boris Rogelj, Janja Božič, Tomaž Bratkovič   +2 more
openaire   +2 more sources

Nucleolar Localization Elements ofXenopus laevisU3 Small Nucleolar RNA [PDF]

Molecular Biology of the Cell, 1998
The Nucleolar Localization Elements (NoLEs) of Xenopus laevis U3 small nucleolar RNA (snoRNA) have been defined. Fluorescein-labeled wild-type U3 snoRNA injected intoXenopus oocyte nuclei localized specifically to nucleoli as shown by fluorescence microscopy. Injection of mutated U3 snoRNA revealed that the 5′ region containing Boxes A and A′, known to
T S, Lange, M, Ezrokhi, A V, Borovjagin, R, Rivera-León, M T, North, S A, Gerbi   +5 more
openaire   +2 more sources

Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

Molecular Cancer, 2010
Background Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy.
Li Ruiyun, Shen Jun, Guarnera Maria, Mei Yuping, Yu Lei, Liao Jipei, Liu Zhenqiu, Jiang Feng   +7 more
doaj   +1 more source

Smoking affects gene expression in blood of patients with ischemic stroke. [PDF]

, 2019
ObjectiveThough cigarette smoking (CS) is a well-known risk factor for ischemic stroke (IS), there is no data on how CS affects the blood transcriptome in IS patients.MethodsWe recruited IS-current smokers (IS-SM), IS-never smokers (IS-NSM), control ...
Ander, Bradley P, Cheng, Xiyuan, Ferino, Eva, Hull, Heather, Jickling, Glen C, Sharp, Frank R, Stamova, Boryana   +6 more
core   +2 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries [PDF]

, 1993
The nuclear topography of splicing snRNPs, mRNA transcripts and chromosome domains in various mammalian cell types are described. The visualization of splicing snRNPs, defined by the Sm antigen, and coiled bodies, revealed distinctly different ...
A Monneron, A Schneider-G�dicke, AK Raap, B Roggenbuck, C Benyajati, C Collins, C Cremer, C Zorn, CA Ascoli, D Pinkel, D Pinkel, DE Comings, DJ Arndt-Jovin, DL Spector, DL Spector, DL Spector, DL Spector, DL Spector, DM Shotton, EA Lerner, G Blobel, GJ Brakenhoff, HTM Voort Van der, I Raska, J Bradl, JB Lawrence, JD Northway, JG Gall, JR Paulson, KC Carter, L Manuelidis, L Manuelidis, L Manuelidis, L Manuelidis, LEC Andrade, M Bachmann, M Bouteille, M Carmo-Fonseca, M Carmo-Fonseca, M Carmo-Fonseca, M Carmo-Fonseca, M Hochstrasser, M Mattioli, M Schardin, N Hutchison, P Lichter, P Lichter, P Lichter, P Lichter, R Berezney, R Reuter, R Verheijen, S Fakan, S Fakan, S Huang, SA Berman, T Cremer, T Cremer, TM Jovin, U Bond, U Nyman, Y Hiraoka, y Ramon, Y Xing, Y Xing   +64 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Long Noncoding RNAs in Metabolic Syndrome Related Disorders

Mediators of Inflammation, 2016
Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (
Magdalena Losko, Jerzy Kotlinowski, Jolanta Jura   +2 more
doaj   +1 more source

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
AA Van Dijk, AE Firth, AE Firth, AG Aminev, AG Aminev, AJ Wilson, Alessia Armezzani, Amr Bayoumy, Andrew Shaw, B Sherry, BJ Erasmus, C Gonzalez-Lopez, C Lee, C Vinson, CC Celma, CD DeMaula, CR Rinaldo Jr, D Grimm, E Calvo-Pinilla, E Calvo-Pinilla, E Matsuo, EL Nason, EW Rainsford, F Arnaud, FM Boisvert, Frazer Rixon, FW Bazer, G Sutton, G Van Heeke, Giulia Franzoni, I Schwartz-Cornil, JA Hiscox, JA Hiscox, JA Mertz, JM Grimes, JM Wehrfritz, Kathryn Allan, L Vazquez-Iglesias, LJ Reed, M Barro, M Boyce, M Boyce, M Caporale, M Caporale, M Marfori, M Mura, M Neville, M Palmarini, M Rojas, M Varela, MA Hofmann, Marco Caporale, Mark Heise, Massimo Palmarini, Matthew Golder, Maxime Ratinier, ME Peeples, MH Malim, MK Estes, MM Arnold, MR Michel, MR Yang, MS Lindstrom, N Feng, N Stauber, NJ Horscroft, NJ Maclachlan, NJ Maclachlan, NJ MacLachlan, NM Foster, P Franchi, P Gouet, P Jameson, P Roy, P Roy, PP Mertens, PP Mertens, PS Mellor, R Dulbecco, R Noad, R Volmer, RE Randall, RJ Owens, S Boulon, S Brandt, S Maan, S Maan, Sandro Filipe Nunes, SH Wang, SJ Wechsler, X Zhang, Z Han   +91 more
core   +4 more sources