Results 71 to 80 of about 442,180 (329)
A high-throughput assay for directly monitoring nucleolar rRNA biogenesis
Open Biology, 2022 Studies of the regulation of nucleolar function are critical for ascertaining clearer insights into the basic biological underpinnings of ribosome biogenesis (RB), and for future development of therapeutics to treat cancer and ribosomopathies.
Carson J. Bryant +4 more
doaj +1 more source
Nucleolar localization signals of Box H/ACA small nucleolar RNAs [PDF]
The EMBO Journal, 1999 The two major families of small nucleolar RNAs (snoRNAs), Box C/D and Box H/ACA, are generated in the nucleoplasm and transported to the nucleolus where they function in rRNA processing and modification. We have investigated the sequences involved in the intranuclear transport of Box H/ACA snoRNAs by assaying the localization of injected fluorescent ...
Andrew A. Lukowiak +8 more
openaire +3 more sources
Diverse human extracellular RNAs are widely detected in human plasma
Nature Communications, 2016 Extracellular miRNAs are present in a variety of bodily fluids. Here, Freedman et al. analysed plasma-derived RNA by RNA-seq from 40 people followed by targeted RT-qPCR in an additional 2,763 people, and report over 1,000 extracellular RNAs including ...
Jane E. Freedman +19 more
doaj +1 more source
Screening Genome Sequences for Known RNA Genes and Motifs [PDF]
, 2015 This methods paper presents computational protocols for the identification of non-coding RNA genes or RNA motifs within genomic sequences. An application to bacterial small RNA is proposed.
arxiv +1 more source
Generalized Iterative Annealing Model for the action of RNA chaperones [PDF]
J. Chem. Phys. (2013) vol. 139, 121924, 2013 As a consequence of the rugged landscape of RNA molecules their folding is described by the kinetic partitioning mechanism according to which only a small fraction ($\phi_F$) reaches the folded state while the remaining fraction of molecules is kinetically trapped in misfolded intermediates.
arxiv +1 more source
Dysregulation of Small Nucleolar RNAs in B-Cell Malignancies
Biomedicines, 2022 Small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modification of ribosomal RNAs, transfer RNAs and small nuclear RNAs, and thereby have important regulatory functions in mRNA splicing and protein translation. Several studies have shown that snoRNAs are dysregulated in human cancer and may play a role in cancer initiation and ...
Martijn W. C. Verbeek +2 more
openaire +3 more sources
The genetic and pharmacogenomic landscape of snoRNAs in human cancer
Molecular Cancer, 2020 Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized.
Yaoming Liu +10 more
doaj +1 more source
A common maturation pathway for small nucleolar RNAs. [PDF]
The EMBO Journal, 1995 We have shown that precursors of U3, U8 and U14 small nucleolar RNAs (snoRNAs) are not exported to the cytoplasm after injection into Xenopus oocyte nuclei but are selectively retained and matured in the nucleus, where they function in pre-rRNA processing.
Michael P. Terns +3 more
openaire +3 more sources
Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
core +2 more sources
Evolution of Fungal U3 snoRNAs: Structural Variation and Introns
Non-Coding RNA, 2017 The U3 small nucleolar RNA (snoRNA) is an essential player in the initial steps of ribosomal RNA biogenesis which is ubiquitously present in Eukarya.
Sebastian Canzler +2 more
doaj +1 more source