Results 11 to 20 of about 15,598 (248)
, 2005 The small ubiquitin-related modifier-1 (SUMO-1) is a 101-amino acid, ~12 kDa protein that is 18% identical to ubiquitin. Posttranslational covalent tagging of proteins with SUMO-1 (SUMOylation) serves many functions. For example, regulation of protein stability and modulation of transcriptional activation. However, very little work has been done on the
Ruijin Shao
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Biomolecules, 2021 Urm1 (ubiquitin related modifier 1) is a molecular fossil in the class of ubiquitin-like proteins (UBLs). It encompasses characteristics of classical UBLs, such as ubiquitin or SUMO (small ubiquitin-related modifier), but also of bacterial sulfur-carrier
Martin Termathe, Sebastian A. Leidel
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Innate Immunity, 2021 Brucella is a genus of Gram-negative intracellular pathogens that cause animal and human diseases. Brucella survival and replication inside immune cells is critical for the establishment of chronic infections.
Yueli Wang +8 more
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Autoantibodies to speckled protein family in primary biliary cholangitis
Allergy, Asthma & Clinical Immunology, 2021 The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients.
Alessandro Granito +3 more
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Cell Death and Disease, 2021 Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinoma ...
Guoxi Zhang +16 more
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Regulation of SUMOylation on RNA metabolism in cancers
Frontiers in Molecular Biosciences, 2023 Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism
Yingting Cao +3 more
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Functional reconstitution of a tunable E3-dependent sumoylation pathway in Escherichia coli. [PDF]
PLoS ONE, 2012 SUMO (small ubiquitin-related modifier) is a reversible post-translational protein modifier that alters the localization, activity, or stability of proteins to which it is attached.
Sean P O'Brien, Matthew P DeLisa
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Ubiquitin-related modifiers of Arabidopsis thaliana influence root development. [PDF]
PLoS ONE, 2014 Ubiquitins are small peptides that allow for posttranslational modification of proteins. Ubiquitin-related modifier (URM) proteins belong to the class of ubiquitin-like proteins. A primary function of URM proteins has been shown to be the sulfur transfer
Florian John +4 more
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SUMOylation in Skeletal Development, Homeostasis, and Disease
Cells, 2022 The modification of proteins by small ubiquitin-related modifier (SUMO) molecules, SUMOylation, is a key post-translational modification involved in a variety of biological processes, such as chromosome organization, DNA replication and repair ...
Huadie Liu +5 more
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Cells, 2023 Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder that appears in adult FMR1 premutation carriers. The neuropathological hallmark of FXTAS is an intranuclear inclusion in neurons and astrocytes.
Maria Isabel Alvarez-Mora +7 more
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