Results 21 to 30 of about 15,598 (248)

Old and New Concepts in Ubiquitin and NEDD8 Recognition

Biomolecules, 2020
Post-translational modifications by ubiquitin and ubiquitin-like proteins (Ubls) have known roles in a myriad of cellular processes. Ubiquitin- and Ubl-binding domains transmit the information conferred by these post-translational modifications by ...
Elena Santonico
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SUMOylation and related post-translational modifications in natural killer cell anti-cancer responses

Frontiers in Cell and Developmental Biology, 2023
SUMOylation is a reversible modification that involves the covalent attachment of small ubiquitin-like modifier (SUMO) to target proteins, leading to changes in their localization, function, stability, and interactor profile.
Rosa Molfetta, Sara Petillo, Marco Cippitelli, Rossella Paolini   +3 more
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SUMOylation in Drosophila Development

Biomolecules, 2012
Small ubiquitin-related modifier (SUMO), an ~90 amino acid ubiquitin-like protein, is highly conserved throughout the eukaryotic domain. Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins.
Albert J. Courey, Wiam Turki-Judeh, Matthew Smith   +2 more
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Function and regulation of ubiquitin-like SUMO system in heart

Frontiers in Cell and Developmental Biology, 2023
The small ubiquitin-related modifier (SUMOylation) system is a conserved, reversible, post-translational protein modification pathway covalently attached to the lysine residues of proteins in eukaryotic cells, and SUMOylation is catalyzed by SUMO ...
Ying Wang, Ying Wang, Zhihao Liu, Zhihao Liu, Xiyun Bian, Xiyun Bian, Chenxu Zhao, Xin Zhang, Xiaozhi Liu, Xiaozhi Liu, Nan Wang   +10 more
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Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster

Biology Open, 2019
The small protein modifier ubiquitin regulates various aspects of cellular biology through its chemical conjugation onto proteins. Ubiquitination of proteins presents itself in numerous iterations, from a single mono-ubiquitination event to chains of ...
Jessica R. Blount, Danielle N. Meyer, Camille Akemann, Sean L. Johnson, Katherine Gurdziel, Tracie R. Baker, Sokol V. Todi   +6 more
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Neuronal Localization of SENP Proteins with Super Resolution Microscopy

Brain Sciences, 2020
SUMOylation of proteins plays a key role in modulating neuronal function. For this reason, the balance between protein SUMOylation and deSUMOylation requires fine regulation to guarantee the homeostasis of neural tissue. While extensive research has been
Luca Colnaghi, Andrea Conz, Luca Russo, Clara A. Musi, Luana Fioriti, Tiziana Borsello, Mario Salmona   +6 more
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SUMOylation in the control of cholesterol homeostasis [PDF]

Open Biology, 2020
SUMOylation—protein modification by the small ubiquitin-related modifier (SUMO)—affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates.
Ana Talamillo, Leiore Ajuria, Marco Grillo, Orhi Barroso-Gomila, Ugo Mayor, Rosa Barrio   +5 more
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Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in Archaea

mBio, 2016
The molecular mechanisms of targeted proteolysis in archaea are poorly understood, yet they may have deep evolutionary roots shared with the ubiquitin-proteasome system of eukaryotic cells.
Xian Fu, Rui Liu, Iona Sanchez, Cecilia Silva-Sanchez, Nathaniel L. Hepowit, Shiyun Cao, Sixue Chen, Julie Maupin-Furlow   +7 more
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SUMO Interacting Motifs: Structure and Function

Cells, 2021
Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
Tak-Yu Yau, William Sander, Christian Eidson, Albert J. Courey   +3 more
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An Optimal Ubiquitin-Proteasome Pathway in the Nervous System: The Role of Deubiquitinating Enzymes

Frontiers in Molecular Neuroscience, 2014
The Ubiquitin-Proteasome Pathway (UPP), which is critical for normal function in the nervous system and is implicated in various neurological diseases, requires the small modifier protein ubiquitin to accomplish its duty of selectively degrading short ...
Gorica eRistic, Wei-Ling eTsou, Sokol V Todi   +2 more
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