Results 61 to 70 of about 18,470 (171)

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, Volume 117, Issue 7, Page 2007-2020, July 2026.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

Strategies for the Modification of Vaccinia Virus towards a Better Vaccine Vector

Zoonoses
Vaccinia virus (VACV) confers cross-protective immunity against variola virus, the causative agent of smallpox, and has therefore been extensively exploited as a preventive vaccine.
Hao Sun, Xinwen Chen, Yun Wang
doaj   +1 more source

The Essentials of Smallpox Vaccination [PDF]

The American Journal of the Medical Sciences, 1922
n ...
Rosenau, Milton J., McCOY, George W.
openaire   +2 more sources

HIV‐1 viral load and reservoir size remain stable following SARS‐CoV‐2 mRNA vaccination in people with HIV

HIV Medicine, Volume 27, Issue 7, Page 1120-1131, July 2026.
Abstract Background The potent immunogenicity of mRNA vaccination raised concerns about its impact on HIV‐1 viral load (VL) and reservoir size in people with HIV, which could drive vaccine hesitancy. As part of a prospective clinical trial, we investigated whether SARS‐CoV‐2 mRNA vaccination induced changes in VL and reservoir size after a 1‐year three‐
Oscar Kieri, Bianca B Jütte, Jan Vesterbacka, Soo Aleman, Hans‐Gustaf Ljunggren, Marcus Buggert, J Peter Svensson, Anders Sönnerborg, Piotr Nowak   +8 more
wiley   +1 more source

Non‐negative Gaussian estimation of variance components in random effects models

Canadian Journal of Statistics, Volume 54, Issue 2, June 2026.
Abstract When used to estimate variance components (VCs), confidence intervals (CIs) can be truncated at zero, have a point estimate not in the quoted CI, be empty with positive probability, or be all‐inclusive. This is because they have conflicting dual roles, since they are considered to cover the parameter with a specified probability while also ...
André Plante, Michael Plante
wiley   +1 more source

Smallpox vaccinations. [PDF]

American Journal of Public Health, 1972
E A, Piszczek, G F, Lull, E L, Stebbins, J, Adriani, O K, Niess   +4 more
openaire   +3 more sources

Le vaccin et ses simulacres : instaurer un être pour gérer une population, 1800-1865

Tracés, 2011
The story of the smallpox vaccine is of particular interest for analysing the role of knowledge in the exercise of power after the Revolution. Rather than establishing compulsory vaccination, the French Government decided to intervene in the medical ...
Jean-Baptiste Fressoz
doaj   +1 more source

Levels of antibodies against the monkeypox virus compared by HIV status and historical smallpox vaccinations: a serological study

Emerging Microbes and Infections
Men who have sex with men and people living with HIV are disproportionately affected in the 2022 multi-country monkeypox epidemic. The smallpox vaccine can induce cross-reactive antibodies against the monkeypox virus (MPXV) and reduce the risk of ...
Dapeng Li, Haiyan Wang, Liqin Sun, Jiamin Feng, Wenting Li, Lin Cheng, Xuejiao Liao, Yangzhen Zhang, Zhongxian Xu, Xiangyang Ge, Bing Zhou, Juanjuan Zhao, Bin Ju, Hongzhou Lu, Zheng Zhang   +14 more
doaj   +1 more source

ACAM2000 vaccine safety and immunogenicity considerations for smallpox and mpox

Expert Review of Vaccines
Introduction Smallpox, eradicated globally in 1980, remains a major biodefense concern due to retained Variola virus stocks and the absence of population immunity following cessation of routine vaccination. Monkeypox virus (MPXV), a related orthopoxvirus,
Vanja Komlenovic, James McCarty, David Cassie, Ravi Anantha, Kevin Yeo, Mario Rodriguez, Bojan Drobic   +6 more
doaj   +1 more source