Results 51 to 60 of about 20,396 (218)

Smallpox vaccines for biodefense [PDF]

Vaccine, 2009
Few diseases can match the enormous impact that smallpox has had on mankind. Its influence can be seen in the earliest recorded histories of ancient civilizations in Egypt and Mesopotamia. With fatality rates up to 30%, smallpox left its survivors with extensive scarring and other serious sequelae.
Richard B, Kennedy, Inna, Ovsyannikova, Gregory A, Poland   +2 more
openaire   +2 more sources

HIV‐1 viral load and reservoir size remain stable following SARS‐CoV‐2 mRNA vaccination in people with HIV

HIV Medicine, EarlyView.
Abstract Background The potent immunogenicity of mRNA vaccination raised concerns about its impact on HIV‐1 viral load (VL) and reservoir size in people with HIV, which could drive vaccine hesitancy. As part of a prospective clinical trial, we investigated whether SARS‐CoV‐2 mRNA vaccination induced changes in VL and reservoir size after a 1‐year three‐
Oscar Kieri, Bianca B Jütte, Jan Vesterbacka, Soo Aleman, Hans‐Gustaf Ljunggren, Marcus Buggert, J Peter Svensson, Anders Sönnerborg, Piotr Nowak   +8 more
wiley   +1 more source

Approaches to Reduce Adverse Effect of Vaccinia Virus in Orally Immunized Mice

Проблемы особо опасных инфекций, 2016
Objective of the investigation was to model the adverse action of vaccinia virus (VV), caused by oral immunization of mice and to evaluate efficacy of its reduction, using therapeutic and prophylactic drugs. Materials and methods.
D. O. Galakhova, Ar. A. Sergeev, E. V. Shevtsova, Al. A. Sergeev, A. S. Zamedyanskaya, K. A. Titova, L. N. Shishkina, L. E. Bulychev, S. V. Borisevich, V. N. Podkuiko, A. P. Pirozhkov, A. V. Koval’Chuk, Ya. V. Polyansky, E. Yu. Vakhnov, V. V. Perekrest, V. A. Shevtsov, A. P. Agafonov, A. N. Sergeev   +17 more
doaj   +1 more source

Monkeypox in humans – the review

Journal of Education, Health and Sport, 2022
Monkeypox is an emerging zoonotic disease caused by the monkeypox virus with a presentation similar to smallpox. Being previously endemic to Africa, now the disease is spreading across the world, causing fear of a potential next pandemic.
Konrad Warchoł, Adam Jasiura , Kamila Giżewska, Aleksandra Wójcik , Sylwiusz Niedobylski   +4 more
doaj   +1 more source

How Fragmented Are Global Policy Debates on Health Data Sharing? Studying Fragmentation Through Discourse Network Analysis

JCMS: Journal of Common Market Studies, EarlyView.
Abstract Global policy‐making is often described as taking place in a fragmented and complex institutional landscape. In this article, we revisit the verdict of fragmentation through the lens of discourse network analysis, seeking to understand the extent to which global policy debates can be characterised as fragmented.
Maria Weickardt Soares, Anna Holzscheiter   +1 more
wiley   +1 more source

We Are Our Memory: A Flexible Framework for Quantifying the Demographic Imprints of the Past

Population and Development Review, EarlyView.
Abstract Populations have demographic connections to the past: people who were exposed to the past may still be alive or may at least have living kin. Denton and Spencer and Alburez‐Gutierrez have recently articulated the concept of “demographic memory” to refer to the way in which the memory of single events lingers in populations through their age or
Hampton Gaddy
wiley   +1 more source

Preclinical Studies of the Specific Activity of the Live Culture Vaccine VACD6 against Smallpox and other Orthopoxvirus Infections

Эпидемиология и вакцинопрофилактика, 2023
Relevance. The epidemiological situation in the world is characterized by an increase in the incidence of orthopoxvirus infections in humans and animals.
S. N. Shchelkunov, S. N. Yakubitskiy, A. E. Nesterov, I. V. Kolosova, A. A. Sergeev, А. V. Zaykovskaya, A. S. Kabanov, Е. A. Nechaeva, M. P. Bogryantseva, S. V. Usova, N. S. Kutserubova, T. V. Tregubchak, E. V. Gavrilova, R. A. Maksyutov   +13 more
doaj   +1 more source

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

Vaccines for preventing smallpox [PDF]

Cochrane Database of Systematic Reviews, 2004
Smallpox was eradicated by 1980, but its possible use as a bioweapon has rekindled interest in the development of protective vaccines. Therefore, stockpiled calf lymph-derived vaccines and recently developed cell-cultured vaccines have been investigated to contribute information to smallpox emergency response plans, while newer (non-replication ...
Metzger, W., Mordmüller, B.
openaire   +3 more sources

Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial

, 2010
Background: Current conventional vaccination approaches do not induce potent CD8 T-cell responses for fighting mostly variable viral diseases such as influenza, avian influenza viruses or HIV.
van der Werf, Sylvie, Christine Katlama, Annika Vogt, Dominique Costagliola, Katlama, Christine, Sabrina Hadam, Behazine Combadière, Sterry, Wolfram, Vogt, Annika, Costagliola, Dominique, Autran, Brigitte, Blume-Peytav, Ulrike, Brice Mahé, Wolfram Sterry, Bonduelle, Olivia, Shlomo Staszewski, Ulrike Blume-Peytavi, Brigitte Autran, Olivia Bonduelle, Blume-Peytavi, Ulrike, Combadière, Behazine, Mahé, Brice, Hadam, Sabrina, Schaefer, Hans, Staszewski, Shlomo, Hans Schaefer, Sylvie van der Werf   +26 more
core   +1 more source