Results 171 to 180 of about 15,084 (212)

Construction and verification of a prognostic model for prostate cancer based on ribosome biogenesis-related genes. [PDF]

BMC Med Genomics
Xie J, Tang Y, Wang Y, Gao X, Fu F, Liu Y, Yi C, Zhou G, Wang Z, Chen C, Jin P, Cai Y, Zhou J.   +12 more
europepmc   +1 more source

Effective management of SMARCA4-deficient undifferentiated tumor by immunotherapy combined with chemotherapy and radiotherapy: Case report. [PDF]

Medicine (Baltimore)
Liang X, Zheng T, Ge Q, Huang R.
europepmc   +1 more source

Clinical characteristics and prognostic analysis of SMARCA4‐deficient non‐small cell lung cancer

Cancer Medicine, 2023
Purpose To improve the understanding of special types of tumors, we summarized and analyzed the clinicopathological features and prognostic factors of SMARCA4‐deficient non‐small cell lung cancer (SMARCA4‐dNSCLC).
Xiyue Liang
exaly   +2 more sources

Exceptionally rapid response to pembrolizumab in a SMARCA4‐deficient thoracic sarcoma overexpressing PD‐L1: A case report

Thoracic Cancer, 2019
SMARCA4‐deficient thoracic sarcoma (SMARCA4‐DTS) is a new clinical entity characterized by SMARCA4 inactivation and has a dismal prognosis because of rapid growth. Effective treatments for SMARCA4‐DTS have not yet been developed.
Kohichi Takada
exaly   +2 more sources

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Recurrent Loss of SMARCA4 in Sinonasal Teratocarcinosarcoma

American Journal of Surgical Pathology, 2020
Molecular analysis has reshaped the landscape of high grade sinonasal tumors by defining novel entities and identifying recurrent mutations in established tumor types. However, sinonasal teratocarcinosarcoma (TCS), a rare and aggressive tumor with intermixed teratomatous, carcinomatous, and sarcomatous elements, remains poorly understood.
Rooper, Lisa M, Ud Din, Nasir, Gagan, Jeffrey, Brosens, Lodewijk A A, Magliocca, Kelly R, Edgar, Mark A, Thompson, Lester D R, Agaimy, Abbas, Bishop, Justin A   +8 more
openaire   +5 more sources

Germline pathogenic SMARCA4 variants in neuroblastoma

Journal of Medical Genetics, 2023
Heterozygous germline pathogenic variants (GPVs) in SMARCA4, the gene encoding the ATP-dependent chromatin remodelling protein SMARCA4 (previously known as BRG1), predispose to several rare tumour types, including small cell carcinoma of the ovary, hypercalcaemic type, atypical teratoid and malignant rhabdoid tumour, and uterine sarcoma.
Leora Witkowski, Kim E. Nichols, Marjolijn Jongmans, Nienke van Engelen, Ronald R de Krijger, Jennifer Herrera-Mullar, Lieve Tytgat, Armita Bahrami, Helen Mar Fan, Aimee L Davidson, Thomas Robertson, Michael Anderson, Martin Hasselblatt, Sharon E. Plon, William D Foulkes   +14 more
openaire   +4 more sources

Cytology of SMARCA4-Deficient Thoracic Neoplasms: Comparative Analysis of SMARCA4-Deficient Non-Small Cell Lung Carcinomas and SMARCA4-Deficient Thoracic Sarcomas

Acta Cytologica, 2020
<b><i>Introduction:</i></b> Inactivating mutations of the <i>SMARCA4</i> (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4) gene and/or loss of the BRG1 (brahma-related gene 1) protein defines SMARCA4-deficient thoracic sarcoma (SMARCA4-dTS), an aggressive neoplasm ...
Aruna Nambirajan, Rimlee Dutta, Prabhat Singh Malik, Lukas Bubendorf, Deepali Jain   +4 more
openaire   +3 more sources

The first case of SMARCA4-deficient sarcoma of stomach

Clinical Journal of Gastroenterology, 2022
SMARCA4-deficient sarcoma was first reported in the chest and recently in the uterus, but not in the stomach. Here, we present a patient diagnosed with SMARCA4-deficient sarcoma of the stomach, using histochemistry. An emergency operation was performed due to perforation of the tumor.
Takayuki Ota, Takeshi Ishikawa, Ritsu Yasuda, Tomoyo Yasuda, Tetsuya Okayama, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Tomohiro Takagi, Hideyuki Konishi, Yuji Naito, Kiichi Matsuyama, Tomohiro Yamaguchi, Kazuo Ootsuka, Akihiko Yoshida, Mitsuo Kishimoto, Yoshito Itoh   +18 more
openaire   +2 more sources

Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas

Gene Expression Patterns, 2013
The iroquois 7 (irx7) in zebrafish encodes a homeodomain transcription factor (TF) in the retinal differentiation network regulated by smarca4, a component of chromatin remodeling complex. The function of Irx7 on retinal development has recently been revealed by antisense morpholino knockdown experiments. In particular, the normal expression of irx7 in
Yuqing, Zhang, Sylvia, Bonilla, Leelyn, Chong, Yuk Fai, Leung   +3 more
openaire   +2 more sources