Results 181 to 190 of about 15,084 (212)

SMARCA4: Promises and challenges in the treatment of cancers

Cancer Letters
The SWI/SNF (switch/sucrose non-fermentable) related BAF (BRG1/BRM-related factor) chromatin remodeling complex subunit ATPase 4 (SMARCA4) is a gene with a high mutation frequency in the SWI/SNF complex. It plays a role as an ATP-dependent catalytic subunit, participates in remodeling chromatin structure and regulation of gene expression, and is ...
Wei Ye, Ding An, Wen-Bin Ou
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A pan-cancer analysis of SMARCA4 alterations and the unique clinicogenomic characteristics associated with SMARCA4 mutation types.

Journal of Clinical Oncology
3073 Background: SWI/SNF complexes are regulators of cell lineage and alterations in these proteins occur in >20% of solid tumors with SMARCA4being the most common. SMARCA4 mutations are associated with worse clinical outcomes in various cancer types but are also vulnerable to novel SMARCA2 inhibitors currently being evaluated in clinical trials ...
Michael Gormally, Matteo Repetto, Justin Jee, Jason C. Chang, Pier Selenica, Andrea Gazzo, Allison L. Richards, Mark Donoghue, Carol Aghajanian, Jorge S. Reis-Filho, Britta Weigelt, Alexander E. Drilon, Robin Guo   +12 more
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SMARCA4-Deficient Poorly Differentiated Adenocarcinoma of the Gallbladder

Clinical Nuclear Medicine
Abstract A 64-year-old woman presented with chest pain while eating and was referred to our hospital. Physical examination revealed abdominal distension, tenderness, and lower-extremity edema. Imaging revealed a large gallbladder tumor infiltrating the liver, with ascites and pleural effusion.
Sho Koyasu, Akihiko Sugimoto, Junichi Matsubara, Manabu Muto, Yuji Nakamoto   +4 more
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Treatment for SMARCA4-deficient carcinoma of uterine cervix

BMJ Case Reports
SMARCA4-deficient undifferentiated cervical carcinoma is an extremely rare and aggressive malignancy, and effective treatment options are lacking. We experienced a rare case involving a patient with SMARCA4-deficient undifferentiated cervical carcinoma who was successfully managed in the long term. A woman in her 40s presented with a chief complaint of
Takuya Yokoe, Kaede Oku, Yuri Noda, Masato Kita   +3 more
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SMARCA4-Deficient Thoracic Sarcoma

International Journal of Surgical Pathology, 2020
Oliver Foot, Magnus Hallin, Robin L. Jones, Khin Thway   +3 more
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SMARCA4 dUT

2023
Kutty Sharada Vinod, Ayush Goel, Pranay, C., Ridhi Sood, Jain, Deepali, Shekh, Irfan, Saurabh Mittal, Tiwari, Pawan, Hadda, Vijay, Madan, Karan, Anant Mohan   +10 more
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A novel oncogenic nonsense mutation of SMARCA4 and genetic characteristic analysis of SMARCA4 (BRG1)-deficient undifferentiated tumor of the bladder

Virchows Archiv
SMARCA4 (BRG1)-deficient undifferentiated tumor is a rare and highly aggressive malignant tumor. Cases arising in the bladder are exceedingly rare, and their molecular pathogenesis remains poorly understood. Here, we present the first, to our knowledge, report of a case of bladder SMARCA4 (BRG1)-deficient undifferentiated tumor incorporating ...
Xing-wang Lu, Chun-meng Ning, Bo Gao
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Germline pathogenic SMARCA4 variants in neuroblastoma

2023
Heterozygous germline pathogenic variants (GPVs) in SMARCA4, the gene encoding the ATP-dependent chromatin remodelling protein SMARCA4 (previously known as BRG1), predispose to several rare tumour types, including small cell carcinoma of the ovary, hypercalcaemic type, atypical teratoid and malignant rhabdoid tumour, and uterine sarcoma.
Witkowski, Leora, Nichols, Kim E., Jongmans, Marjolijn, Van Engelen, Nienke, De Krijger, Ronald R., Herrera-Mullar, Jennifer, Tytgat, Lieve, Bahrami, Armita, Mar Fan, Helen, Davidson, Aimee L., Robertson, Thomas, Anderson, Michael, Hasselblatt, Martin, Plon, Sharon E., Foulkes, William D., Genetica, Genetica Klinische Genetica, Cancer, Child Health, Pathologie Pathologen staf, Pathologie Groep Van Diest   +20 more
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Atezolizumab with bevacizumab, paclitaxel and carboplatin was effective for patients with SMARCA4-deficient thoracic sarcoma

Immunotherapy, 2021
Kei Kunimasa, Yoji Kukita, Keiichiro Honma   +2 more
exaly  

SMARCA4 Mutations in Carcinomas of the Esophagus, Esophagogastric Junction, and Stomach

Modern Pathology, 2023
Fei Dong, Alexander J. Neil, Raymond A Isidro   +2 more
exaly