Results 11 to 20 of about 15,084 (212)

The role of SMARCA4 in lung cancer

Scientific Reports
Lung cancer remains one of the leading causes of mortality among cancer patients. Chromatin remodeling is a crucial epigenetic process in cancer, primarily regulated by alterations in genes encoding subunits of the switch/sucrose non-fermentable (SWI/SNF) complex.
Wang, Guimei, Zhou, Guoqi, Han, Weidong, Jiang, Hanliang   +3 more
openaire   +3 more sources

Gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT): a clinicopathological analysis of four rare cases

Orphanet Journal of Rare Diseases
Abstract Background SMARCA4, as one of the subunits of the SWI/SNF chromatin remodeling complex, drives SMARCA4-deficient tumors. Gastric SMARCA4-deficient tumors may include gastric SMARCA4-deficient carcinoma and gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT).
Ping Zhou, Yiyun Fu, Weiya Wang, Yuan Tang, Lili Jiang   +4 more
openaire   +3 more sources

Analysis of smarca4 and smarca2 loss in lung sarcomatoid carcinomas

Turkish Journal of Pathology, 2022
Sarcomatoid carcinomas of the lung are a group of aggressive tumors. It has been reported that losses of SMARCA4 and SMARCA2, which play a role in the repair and remodeling of chromatin, contribute to the initiation, progression, and differentiation of neoplasms. The aim of our study was to examine SMARCA4 and SMARCA2 profiles in sarcomatoid carcinomas
Halide Nur URER, Nurcan UNVER, Neslihan FENER   +2 more
openaire   +3 more sources

Thoracic SMARCA4-deficient tumors: a clinicopathological analysis of 52 cases with SMARCA4-deficient non-small cell lung cancer and 20 cases with thoracic SMARCA4-deficient undifferentiated tumor [PDF]

PeerJ
Background Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a distinct clinicopathological entity with an aggressive clinical course. Additionally, SMARCA4/BRG1 deficiency can be observed in a few patients with non-small cell lung cancer (NSCLC).
Zhou, Ping, Fu, Yiyun, Tang, Yuan, Jiang, Lili, Wang, Weiya   +4 more
openaire   +5 more sources

SMARCA4-deficient non-small cell lung cancer and immunotherapy resistance: mechanisms and novel strategies-a mini-review. [PDF]

Discov Oncol
SMARCA4 deficient thoracic tumors represent an aggressive subset of malignancies characterized by inactivating mutations in the SMARCA4 gene, a core component of the SWI/SNF chromatin remodeling complex.
Lin X, Ji Y, Lin B, Yang Z, Xie R.
europepmc   +2 more sources

Clinicopathological characteristics and therapeutic outcomes in patients with non-small cell lung cancer harboring SMARCA4 mutations. [PDF]

Ann Med
Objective To investigate the clinical characteristics and impact of SMARCA4 mutations in patients with non-small cell lung cancer (NSCLC).Methods A total of 2,821 patients with NSCLC who underwent next-generation sequencing were retrospectively included.
Liu Y, Li H, Li X, Cui H, Li R, Zhu J, Cui H, Liu Y, Cheng Y.   +8 more
europepmc   +2 more sources

SMARCA4 deficiency in glioblastoma: Mitochondrial transfer from MSCs and the clinical dilemma in targeting the tumor microenvironment. [PDF]

Neoplasia
Introduction: SMARCA4, a pivotal transcription activator regulating chromatin structure, gene expression, and cellular energy metabolism, has well-documented roles in various cancers.
Yang F, Chen L, Shi Y, Wang L, Tong M.
europepmc   +2 more sources

Evaluation of Efficacy and Prognosis Analysis of Stage III-IV SMARCA4-deficient 
Non-small Cell Lung Cancer Treated by PD-1 Immune Checkpoint Inhibitors plus 
Chemotherapy and Chemotherapy

Chinese Journal of Lung Cancer, 2023
Background and objective The SMARCA4 mutation has been shown to account for at least 10% of non-small cell lung cancer (NSCLC). In the present, conventional radiotherapy and targeted therapy are difficult to improve outcomes due to the highly aggressive ...
Xinjuan WANG, Meng TU, Hongxia JIA, Hongping LIU, Yan WANG, Yibo WANG, Nan JIANG, Chunya LU, Guojun ZHANG   +8 more
doaj   +1 more source

Tumor suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression across diverse biological processes in lung cancer. [PDF]

Front Cell Dev Biol
IntroductionThe tumor suppressor kinase liver kinase B1 (LKB1) is known to regulate the activity of the metabolic sensor AMP-activated protein kinase (AMPK), which, under energy stress, shifts metabolism from anabolism to catabolism, thus linking LKB1 to
Bourouh M, Kim J, Marignani PA.
europepmc   +2 more sources

Thoracic SMARCA4-Deficient Undifferentiated Tumor With ALK Fusion Treated With Alectinib Achieved Remarkable Tumor Regression: Case Report

JTO Clinical and Research Reports, 2023
Recently, SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) has emerged as a distinct subset of lung cancer. Previous studies have suggested that SMARCA4-UT is often associated with smoking-related mutations, such as KRAS and STK11, rather than EGFR ...
Jin Sheng, MD, Weidong Han, MD, PhD, Hongming Pan, MD, PhD   +2 more
doaj   +1 more source