Results 41 to 50 of about 15,084 (212)

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition i [PDF]

, 2017
The Nucleosome Remodeling and Deacetylase (NURD) complex is a key regulator of cell differentiation that has also been implicated in tumorigenesis. Loss of the NURD subunit Deleted in Oral Cancer 1 (DOC1) is associated with human oral squamous cell ...
Baatenburg de Jong, R.J. (Robert Jan), Bezstarosti, K. (Karel), Bot, A.G. (Alice), Demmers, J.A.A. (Jeroen), Fodde, R. (Riccardo), Herdt, M.J. (Maria) de, IJcken, W.F.J. (Wilfred) van, Looijenga, L.H.J. (Leendert), Mohd-Sarip, A. (Adone), Oole, E. (Edwin), Riet, J. (Job) van, Teeuwssen, M. (Miriam), Verrijzer, C.P. (Peter), Werken, H.J.G. (Harmen) van de, Willems, S.M. (Stefan Martin), Zatreanu, D. (Diana)   +15 more
core   +1 more source

Expression inactivation of SMARCA4 by microRNAs in lung tumors [PDF]

Human Molecular Genetics, 2014
SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor role of the SWI/SNF complex in cancer. However, although
Isabel F, Coira, Eva E, Rufino-Palomares, Octavio A, Romero, Paola, Peinado, Chanatip, Metheetrairut, Laura, Boyero-Corral, Julian, Carretero, Esther, Farez-Vidal, Marta, Cuadros, Fernando J, Reyes-Zurita, Jose A, Lupiáñez, Montse, Sánchez-Cespedes, Frank J, Slack, Pedro P, Medina   +13 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Case Report: SMARCA4 (BRG1)-deficient undifferentiated carcinoma of gallbladder with genetic analysis

Frontiers in Oncology, 2023
SMARCA4 (BRG1)-deficient undifferentiated carcinoma is a rare and highly aggressive malignancy. It has been reported to occur in a multiple range of organs.
Xiangpeng Meng, Jia Ma, Nan Meng, Tianyu Yun, Beifang Niu, Beifang Niu, Beifang Niu   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An unrecognized undifferentiated tumor of the pancreas: a case report

Journal of Pancreatology, 2023
SMARCA4-deficient tumors are gaining attention, and this type of tumor is highly malignant with a poor prognosis. The frequency of SMARCA4 deletion varies in different tumors. However, it has never been identified in the pancreas.
Chaoyu Pang, Zhiyao Fan, Peng Su, Hanxiang Zhan   +3 more
doaj   +1 more source

Effective osimertinib treatment in a patient with discordant T790 M mutation detection between liquid biopsy and tissue biopsy. [PDF]

, 2018
BACKGROUND:We report the successful treatment of the patient with osimertinib 80 mg/day following disease progression and a discordance in the detection of a mechanism of resistance epithelial growth factor receptor (EGFR) T790 M between liquid biopsy ...
Mambetsariev, Isa, Salgia, Ravi, Vora, Lalit, Yu, Kim Wai   +3 more
core   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss

Nature Communications, 2023
SMARCA4 (BRG1) and SMARCA2 (BRM) are the two paralogous ATPases of the SWI/SNF chromatin remodeling complexes frequently inactivated in cancers. Cells deficient in either ATPase have been shown to depend on the remaining counterpart for survival ...
Xianbing Zhu, Zheng Fu, Shary Y. Chen, Dionzie Ong, Giulio Aceto, Rebecca Ho, Jutta Steinberger, Anie Monast, Virginie Pilon, Eunice Li, Monica Ta, Kyle Ching, Bianca N. Adams, Gian L. Negri, Luc Choiniere, Lili Fu, Kitty Pavlakis, Patrick Pirrotte, Daina Z. Avizonis, Jeffrey Trent, Bernard E. Weissman, Ramon I. Klein Geltink, Gregg B. Morin, Morag Park, David G. Huntsman, William D. Foulkes, Yemin Wang, Sidong Huang   +27 more
doaj   +1 more source

eIF4A inhibitors suppress cell-cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer [PDF]

, 2019
CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including KRAS-mutant non-small cell lung cancer (NSCLC).
Cencic, Regina, Foulkes, William D., Fu, Zheng, Guiot, Marie-Christine, Huang, Sidong, Kong, Tim, Monast, Anie, Park, Morag, Pelletier, Jerry, Pilon, Virginie, Porco, John A., Sangwan, Veena, Xue, Yibo, Zhu, Xianbing   +13 more
core   +1 more source