Results 51 to 60 of about 15,084 (212)

Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study

Head &Neck, EarlyView.
ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange, Mathilde Morisseau, Justin Michel, Thibaut Reverdy, Sylvain Morinière, Amaury Daste, Maxime Humbert, Caroline Viala, Pauline Corbaux, Tiffany Darbas, François‐Régis Ferrand, Valentin Favier, Camille Evrard, Diane Evrard, Delphine Farneti, Sarah Betrian‐Lagarde, Victor Sarradin   +16 more
wiley   +1 more source

SMARCA4 mutations and expression in lung adenocarcinoma: prognostic significance and impact on the immunotherapy response

FEBS Open Bio
The switch/sucrose non‐fermenting (SWI/SNF) complex family includes important chromatin‐remodeling factors that are frequently mutated in lung adenocarcinoma (LUAD).
Yuming Zhang, Dantong Sun, Weizhong Han, Zhen Yang, Yongzhi Lu, Xuchen Zhang, Yongjie Wang, Chuantao Zhang, Ning Liu, Helei Hou   +9 more
doaj   +1 more source

Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues [PDF]

, 2018
Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired diseases, including HIV and COPD, affect specific muscles while sparing others.
Andrade, Francisco, Douglas, Collin M, Esser, Karyn A, Gong, Ming C, Gutierrez-Monreal, Miguel A, Hoffmann, Christy, Hughes, Laura D, Hughes, Michael E, Lahens, Nicholas F, Lewis, Scott A, Li, Jiajia, Riley, Lance A, Terry, Erin E, Wallace, Matthew J, Zhang, Xiping   +14 more
core   +4 more sources

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B–BCL6 Regulatory Circuit in Burkitt Lymphoma

International Journal of Cancer, EarlyView.
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier, Karolina Rassek, Yichen Liu, Annika Seitz, Jasper Koerts, Debora de Jong, Bea Rutgers, Anastasiia Kompaniiets, Julia Przybył, Martine E. D. Chamuleau, Anke van den Berg, Agnieszka Dzikiewicz‐Krawczyk, Joost Kluiver   +12 more
wiley   +1 more source

Clinicopathological characteristics and treatment outcomes of advanced SMARCA4‐deficient thoracic tumors

Cancer Medicine
Purpose SMARCA4‐deficient thoracic tumors, characterized by distinct clinicopathological, morphological, immunohistochemical, and genetic features, differ significantly from conventional non‐small‐cell lung carcinomas (NSCLCs).
Anni Wang, Yueping Jin, Zhengqi Cao, Li Lu, Ziming Li   +4 more
doaj   +1 more source

Conversion Surgery for Advanced Thoracic SMARCA4-Deficient Undifferentiated Tumor With Atezolizumab in Combination With Bevacizumab, Paclitaxel, and Carboplatin Treatment: A Case Report

JTO Clinical and Research Reports, 2021
A SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a rapidly progressing subtype of lung cancer with a poor prognosis and causes early postoperative recurrence among operable patients. In this study, we present a case of SMARCA4-UT with vertebral
Kei Kunimasa, MD, PhD, Jiro Okami, MD, PhD, Satoshi Takenaka, MD, PhD, Keiichiro Honma, MD, PhD, Yoji Kukita, PhD, Shigenori Nagata, MD, PhD, Takahisa Kawamura, MD, PhD, Takako Inoue, MD, Motohiro Tamiya, MD, Hanako Kuhara, MD, PhD, Kazumi Nishino, MD, PhD, Hideaki Tahara, MD, PhD, Toru Kumagai, MD, PhD   +12 more
doaj   +1 more source

Progress in the development of non-​BET bromodomain chemical probes [PDF]

, 2016
The bromodomain and extra terminal (BET) family of bromodomains have been the focus of extensive research, leading to the development of many potent, selective chem. probes and recent clinical assets. The profound biol.
Arrowsmith, Bamborough, Bantscheff, Borah, Brand, Bunnage, Caron, Chaikuad, Chung, Chung, Chung, Chung, Clark, Coudé, Dawson, Demont, Demont, Drouin, Fedorov, Fedorov, Ferguson, Filippakopoulos, Filippakopoulos, Filippakopoulos, Fish, Furdas, Gallenkamp, Garnier, Gerona-Navarro, Gu, Guetzoyan, Harner, Hay, Hay, Hewings, Hewings, Hewings, Hohmann, Jennings, Knapp, Machleidt, McKeown, McLure, Medina, Mirguet, Mirguet, Mujtaba, Mujtaba, Mujtaba, Müller, Nicodeme, Philpott, Piatnitski Chekler, Picaud, Picaud, Prinjha, Rooney, Sachchidanand, Sanchez, Seal, Sweis, Sweis, Ullah, Vangamudi, Vidler, Werner, Zeng, Zhang   +67 more
core   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source

Integrated genomic characterization of oesophageal carcinoma [PDF]

, 2017
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and ...
The Cancer Genome Atlas Research Network
core   +1 more source