Results 71 to 80 of about 15,084 (212)
Histone-Binding of DPF2 Mediates Its Repressive Role in Myeloid Differentiation [PDF]
, 2017 Double plant homeodomain finger 2 (DPF2) is a highly evolutionarily conserved member of the d4 protein family that is ubiquitously expressed in human tissues and was recently shown to inhibit the myeloid differentiation of hematopoietic stem/progenitor ...
Davenport, Andrew M. +7 more
core +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt +76 more
wiley +1 more source
Respirology Case ReportsThoracic SMARCA4‐deficient undifferentiated tumour (SMARCA4‐dUT) is a rare and highly aggressive malignant tumour with poor response to conventional chemotherapy and a poor prognosis, for which there is currently no standard treatment.
Heng You +4 more
doaj +1 more source
Thoracic SMARCA4-deficient undifferentiated tumor
Radiology Case ReportsThoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is characterized by an undifferentiated rhabdoid morphology and SMARCA4 deficiency pathologically. In the 2021 revision of the WHO classification, it was categorized as an epithelial tumor because of its shared genetic background with smoking-related lung cancer.
Yukina Izumi +10 more
openaire +3 more sources
The Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
wiley +1 more source
SMARCA4/BRG1-deficient NSCLC: a case report and literature review
Journal of the Pakistan Medical AssociationPatients with non-small cell lung cancer (NSCLC) deficient in SMARCA4 (SMARCA4-dNSCLC) are commonly diagnosed at advanced stages with a poor prognosis.
He Zhang +5 more
doaj +1 more source
Primary gastric SMARCA4-deficient carcinosarcoma and sarcomatoid carcinoma: Two case reports. [PDF]
Front OncolGastric SMARCA4-deficient carcinosarcoma and sarcomatoid carcinoma are rare with poor prognosis. In the present study, two male patients were hospitalized due to abdominal manifestations, specifically abdominal pain and a sense of fullness and discomfort.
Zhao R, Zhang JJ, Zhi X, Zhang RY, Li L.
europepmc +2 more sources
Sensitization of retinoids and corticoids to epigenetic drugs in MYC-activated lung cancers by antitumor reprogramming [PDF]
, 2017 Components of the SWI/SNF chromatin remodeling complex, including BRG1 (also SMARCA4), are inactivated in cancer. Among other functions, SWI/SNF orchestrates the response to retinoid acid (RA) and glucocorticoids (GC) involving downregulation of MYC. The
Condom i Mundó, Enric +8 more
core +1 more source
The Journal of Pathology, Volume 269, Issue 2, Page 164-181, June 2026.Abstract Lung cancer is the leading cause of global cancer‐related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2‐related factor 2 (NRF2) is a redox‐regulated transcription factor frequently dysregulated in non‐small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy.
Jouni Härkönen +14 more
wiley +1 more source
Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice [PDF]
, 2016 Women with endometriosis can suffer from decreased fecundity or complete infertility via abnormal oocyte function or impaired placental-uterine interactions required for normal pregnancy establishment and maintenance.
Broaddus, Russell +4 more
core +1 more source