Results 91 to 100 of about 15,084 (212)

Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice

Genes and Diseases, 2017
Alveolar epithelial cells (AECs) injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis (PF).
Danyi Peng, Daozhu Si, Rong Zhang, Jiang Liu, Hao Gou, Yunqiu Xia, Daiyin Tian, Jihong Dai, Ke Yang, Enmei Liu, Yujun Shi, Q. Richard Lu, Lin Zou, Zhou Fu   +13 more
doaj   +1 more source

Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity [PDF]

, 2014
The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years. With a five-year survival rate of 15%, identification of new therapeutic targets for EAC is greatly important.
Auclair, Daniel, Bandla, Santhoshi, Bass, Adam J., Beer, David G., Beroukhim, Rameen, Carter, Scott L., Chang, Andrew, Cibulskis, Kristian, Dulak, Austin M., Fox, Cameron, Gabriel, Stacey B., Getz, Gad, Godfrey, Tony E., Golub, Todd R., Guiducci, Candace, Imamura, Yu, Lander, Eric S., Lawrence, Michael S., Lin, Jules, Lin, Lin, Luketich, James D., McKenna, Aaron, Ogino, Shuji, Onofrio, Robert C., Peng, Shouyong, Pennathur, Arjun, Ramos, Alex H., Reddy, Rishindra, Saksena, Gordon, Schumacher, Steven E., Shefler, Erica, Sivachenko, Andrey, Sougnez, Carrie, Stewart, Chip, Stojanov, Petar, Thompson, Kristin, Voet, Douglas, Zhou, David   +37 more
core   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, Volume 101, Issue 5, Page 1025-1035, May 2026.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells [PDF]

, 2019
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation.
García Martínez, Jorge, Guerrero Martínez, José A., Gómez Marín, Elena, Reyes Rosa, José Carlos, Rivero Canalejo, Sabrina   +4 more
core   +2 more sources

Paradoxical Efficacy With Rare Adverse Events: Sequential ALK Inhibitor Therapy in Lung Adenocarcinoma

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Anaplastic lymphoma kinase (ALK) inhibitors have markedly improved outcomes in ALK‐positive nonsmall‐cell lung cancer (NSCLC). While their efficacy is well documented, rare or organ‐specific toxicities remain underreported, limiting clinicians' ability to anticipate and manage adverse events during treatment or rechallenge with tyrosine kinase
Kang Xie, Nie Xu
wiley   +1 more source

A case report of thoracic SMARCA4-deficient undifferentiated tumor associated with brain metastases

Frontiers in Oncology
Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) were considered distinct from the traditional NSCLC with SMARCA4-deficient (SMARCA4-dNSCLC) in the 5th edition of the WHO classification of thoracic tumors in 2021.
Min Yang, Yang Wang, Yang Wang, Xiaolong Fang, Xiaolong Fang, Yuntao Wang, Yuntao Wang, Qingliang Xu, Chunyan Tang, Chunyan Tang, Li Qi, Aijie Li, Aijie Li, Jingjing Li, Jingjing Li   +14 more
doaj   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 780-818, May 2026.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Under the Microscope: A Case Report of Thoracic SMARCA4-Deficient Undifferentiated Tumor with Review of the Literature [PDF]

Türk Patoloji Dergisi
Objective: SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a highly malignant neoplasm with an undifferentiated or rhabdoid phenotype, posing a diagnostic challenge.
Manasi MUNDADA, Khalid ABDUL MANNAN, Divya VASU, Faiq AHMED, Suseela K   +4 more
doaj   +1 more source

A gene-alteration profile of human lung cancer cell lines [PDF]

, 2009
: Aberrant proteins encoded from genes altered in tumors drive cancer development and may also be therapeutic targets. Here we derived a comprehensive gene-alteration profile of lung cancer cell lines.
Angulo, B. (B.), Blanco, R. (R.), Iwakawa, R. (R.), Kohno, T. (Takashi), Minna, J.D. (John D.), Montuenga-Badia, L.M. (Luis M.), Pio, R. (Rubén), Sanchez-Cespedes, M. (Montserrat), Tang, M. (Moying), Yokota, J. (Jun)   +9 more
core  

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy [PDF]

, 2016
How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy.
Buffa, F, Castro-Giner, F, Cazier, J-B, Church, D, Cross, W, Findlay, JM, Gillies, RS, Graham, TA, Kartsonaki, C, Kovac, M, MacGregor, TP, Makino, S, Maynard, ND, Middleton, M, Palles, C, Rayner, E, Sharma, RA, Tomlinson, I, Ulahannan, D, Wang, L-M   +19 more
core   +4 more sources