Results 111 to 120 of about 15,084 (212)

SMARCA4-deficiency: a continuum

Although <em> Thoracic SMARCA4-deficient undifferentiated tumour </em> (SD-UT) is a recognized entity in the 5th edition of the WHO classification of thoracic tumors, this alteration occurs in garden-variety lung cancer as well (and in many other tumors too!) In fact, it is likely SD-UT exists on a continuum with <em> SMARCA4 </em ...
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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design. [PDF]

, 2019
Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited ...
Baxter, Patricia, Bendak, Katerina, Berko, Esther R, Bowen, Jay, Braun, Frank K, Bryan, Anthony C, Böhm, Julia W, Cardenas, Maria F, Chen, Yidong, Coppens, Sara E, Cross, Katherine L, Diskin, Sharon J, Doddapaneni, HarshaVardhan, Du, Yunchen, Egolf, Laura E, Evans, Kathryn, Farrel, Alvin, Gaonkar, Krutika S, Gastier-Foster, Julie M, Gatto, Gregory J, Gorlick, Richard, Greene, Casey S, Haber, Michelle, Hart, Lori S, Haussler, David, Houghton, Peter J, Jayaseelan, Joy, Kalletla, Karthik, Kendsersky, Nathan M, Kolb, E Anders, Krytska, Kateryna, Kurmashev, Dias, Kurmasheva, Raushan T, Leraas, Kristen M, Li, Xiao-Nan, Lindsay, Holly B, Lock, Richard B, Lopez, Gonzalo, Maris, John M, Marshall, Glenn M, Mayoh, Chelsea, McCalmont, Hannah, McCoy, Kristyn, Modi, Apexa, Momin, Zeineen, Morton, Christopher, Mosse, Yael P, Nance, Jonas, Patel, Khushbu, Pfeil, Jacob, Qi, Lin, Raman, Pichai, Rathi, Komal S, Reynolds, C Patrick, Rokita, Jo Lynne, Sacks, Gregory I, Sanchez, Yolanda, Shu, Jack, Smith, Malcolm A, Tyrrell, Vanessa, Upton, Kristen A, Vaksman, Zalman, Vaske, Olena Morozova, Way, Gregory P, Wheeler, David A, Zhang, Huiyuan, Zhang, Wendong, Zhao, Sibo, Zheng, Siyuan   +68 more
core  

Neoadjuvant Immunochemotherapy in Resectable NSCLC With SMARCA4 Alterations

Journal of Thoracic Oncology
Neoadjuvant immunochemotherapy has improved pathologic complete response (pCR) rates and event-free survival in resectable NSCLC, yet its efficacy in SMARCA4-altered NSCLC, a subset associated with poor prognosis, remains unclear.We retrospectively analyzed clinical characteristic and next-generation sequencing of 29 patients with SMARCA4-altered NSCLC
Li-Shan Peng, Qian Cui, Chao Zhang, Jun-Tao Lin, You Wu, Jin Kang, Zi-Yi Xu, Xiang-Yang Wang, Ying-Jiao Cao, Qing-Ling Zhang, Yi-Long Wu, Zheng Hu, Wen-Zhao Zhong   +12 more
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Metastatic SMARCA4-deficient undifferentiated tumor in the small mesentery: case report

World Journal of Surgical Oncology
Background SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a rare and highly malignant primary tumor characterized by the loss of SMARCA4 expression.
Shuai Luo, Xiaoxue Tian, Ting Xu, Jinjing Wang   +3 more
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Prognostic Impact of KRAS and SMARCA4 Mutations and Co-Mutations on Survival in Non-Small Cell Lung Cancer: Insights from the AACR GENIE BPC Dataset

Biomedicines
Background/Objectives: KRAS mutations are among the most prevalent oncogenic drivers in non-small cell lung cancer (NSCLC), with their impact on survival influenced by co-mutations.
Peter Manolakos, Yu-Bo Wang, Janice Withycombe, Luigi Boccuto, Diana Ivankovic   +4 more
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SMARCA4 Gene [PDF]

, 2020
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Thoracic SMARCA4-deficient undifferentiated tumor prone to misdiagnosis as lung adenocarcinoma: a case report and literature review

Frontiers in Oncology
Thoracic SMARCA4-deficient undifferentiated tumor (T-SMARCA4-DUT) is a rare neoplastic entity with a high risk of being misdiagnosed. We report the case of a 64-year-old male initially suspected of having mediastinal lymphoma by contrast-enhanced chest ...
Xiuwen Yu, Ying Cai, Haiyan Wu, Hongsheng Liu, Bin Huang   +4 more
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Case Report: FAP+ fibroblasts and SPP1+ macrophages in SMARCA2-deficient while SMARCA4-preserved poorly differentiated lung adenocarcinoma: two case reports and multi-omics analysis

Frontiers in Immunology
Two ATPase subunits, SMARCA4 (which encodes BRG1) and SMARCA2 (which encodes BRM), facilitate this process by hydrolyzing ATP to energize the activity of the mammalian switch/sucrose-non-fermenting (mSWI/SNF) complexes.
Zhaoxuan Wang, Junying Wang, Shengmin Wang, Weijiao Xu, Yixiang Zhang   +4 more
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Genomic alterations in neuroendocrine cancers of the ovary [PDF]

, 2016

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A case report of SMARCA4-deficient gastric cancer and review of the literature

SAGE Open Medical Case Reports
We report the case of a 50-year-old female with gastric carcinoma. The tumor was positive for epithelial and other immunological markers; however, SMARCA4 was completely inactivated.
Lin Chen, Zhengyi Cheng, Yuqiao Xu, Guodong Fang, Hangrong Fang   +4 more
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