Results 101 to 110 of about 15,084 (212)

SMARCA2 and SMARCA4 participate in DNA damage repair

Frontiers in Bioscience-Landmark
Abstract SMARCA2 and SMARCA4 (SMARCA2/4) are paralogs and act as the key enzymatic subunits in the SWI/SNF complex for chromatin remodeling. However, the role of SMARCA2/4 in DNA damage response remains unclear. Here, we show that SMARCA2/4 relocate to DNA lesions in response to DNA damage, which requires their ATPase activities ...
Lily Yu, Duo Wu
openaire   +3 more sources

Finding More in Less: Precision Medicine for Pancreatic Cancer Using Residual Cytology Samples

Cytopathology, Volume 37, Issue 3, Page 275-283, May 2026.
The study evaluates the use of residual liquid‐based cytology (LBC) samples from pancreatic ductal adenocarcinoma (PDAC) for molecular analysis. It shows that LBC samples preserve nucleic acid quality and remain suitable for next‐generation sequencing (NGS) and MSI testing even after prolonged storage, underscoring their value when other samples are ...
Raquel Antón‐Peñalver, María Ortega, Jose Francisco González‐Muñoz, Desamparados Compañ, Constanza Galindo, Clara Arnau, Marisol Huerta, Valentina Gambardella, Desamparados Roda, Rosana Villagrasa, Vicente Sanchiz, Andrés Peña, Elena Muñoz‐Forner, Isabel Mora Oliver, Luis Sabater, Andrés Cervantes, Antonio Ferrández, Clara Alfaro‐Cervelló   +17 more
wiley   +1 more source

Molecular pathology of phyllodes tumours of the breast—much more than MED12

Histopathology, Volume 88, Issue 6, Page 1115-1125, May 2026.
Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox   +3 more
wiley   +1 more source

SMARCA4-associated schwannomatosis

Acta Neuropathologica, 2023
Fiona Chan-Pak-Choon, Carla Roca, Anne-Sophie Chong, Clara Nogué, Sonja Dahlum, Rachel Austin, Helen Mar Fan, Karin Y. van Spaendonck-Zwarts, Neil K. Lambie, Thomas Robertson, Reiner Siebert, Barbara Rivera, William D. Foulkes   +12 more
openaire   +2 more sources

SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing

Journal of Hematology & Oncology
Introduction Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation.
Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga, Charles M. Rudin   +15 more
doaj   +1 more source

SMARCA4/SMARCA2-Deficient Undifferentiated Metastatic Malignant Tumor with Carcinoma of Unknown Primary: Case Report

Case Reports in Oncology
Introduction: SMARCA4/SMARCA2 deficiencies have been linked to a variety of neoplasms and have been mainly described in cases of thoracic non-small cell lung cancers. Case Presentation: Here we present a case of SMARCA4/SMARCA2-deficient undifferentiated
Amanda Craven, Alexandra Goodman, Dana Hariri, Gustavo de la Roza, Parth Sampat, Bernard Poiesz   +5 more
doaj   +1 more source

Retrospective Insights into the Clinicopathological Features and Treatment Outcomes of Thoracic SMARCA4-Deficient Tumors

Technology in Cancer Research & Treatment
Introduction Thoracic SMARCA4-deficient tumors, which are rare and aggressive malignancies found in the lung or thoracic cavity, present a challenge in treatment standardization. This challenge arises from their resistance to chemotherapy and the absence
Lijin Chen MM, Chunyang Su MM, Jiadi Yao MM, Xiaofeng Li MD, PhD, Xiaoyan Lin MD, PhD   +4 more
doaj   +1 more source

SMARCA4-deficient tumors in the adrenal gland and small intestines: A rare case report

Radiology Case Reports
Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UTs) are rare undifferentiated thoracic malignancies with poor prognosis. They predominantly affect young men who are heavy smokers.
Akira Kambe, MD, Yayoi Yamamoto, MD, PhD, Chie Hasegawa, MD, Akira Kakiuchi, MD, Daichi Kojima, MD, Ayako Hino, MD, PhD, Ayumi Horikawa, MD, PhD, Tsunehiro Doiuchi, MD, Hiroaki Kurihara, MD, PhD   +8 more
doaj   +1 more source

Differential expression of SMARCA4 in cancers of the breast.

, 2022
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of women with breast cancer.
openaire   +1 more source

A 5‐month‐old infant with a pineal tumor

Brain Pathology, Volume 36, Issue 3, May 2026.
Fabien Forest, Martin Hasselblatt, Fanélie Barral‐Clavel, Alix Clemenson, Sandrine Thouvenin, Claire Berger, Anne Mc Leer, Catherine Godfraind   +7 more
wiley   +1 more source