Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
Label-free quantitative proteomics identifies Smarca4 is involved in vascular calcification
Renal Failure, 2019 Vascular calcification (VC) is a pathological process characterized by abnormal deposition of calcium phosphate, hydroxyapatite and other mineral substances in the vascular wall.
Chan Wang +5 more
doaj +1 more source
Interrogation of mammalian protein complex structure, function, and membership using genome-scale fitness screens [PDF]
, 2018 Protein complexes are assemblies of subunits that have co-evolved to execute one or many coordinated functions in the cellular environment. Functional annotation of mammalian protein complexes is critical to understanding biological processes, as well as
Aguirre +74 more
core +1 more source
Andrology, EarlyView.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source
Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation [PDF]
, 2014 Purpose The purpose of this study was to develop a framework for analyzing retinal pigment epithelium (RPE) expression profiles from zebrafish eye mutants.
Collery, Ross +6 more
core
Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks [PDF]
, 2018 Integrated multiomics network analysis reveals signaling profiles in lung cancer.
Clark, Neil R. +14 more
core +1 more source
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
Medulloblastoma Exome Sequencing Uncovers Subtype-Specific Somatic Mutations [PDF]
, 2012 Medulloblastomas are the most common malignant brain tumors in children1. Identifying and understanding the genetic events that drive these tumors is critical for the development of more effective diagnostic, prognostic and therapeutic strategies ...
A Garbelli +68 more
core +2 more sources
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Frontiers in ImmunologySMARCA4-deficient undifferentiated tumor (SMARCA4-dUT) is a devastating subtype of thoracic tumor with SMARCA4 inactivation and is characterized by rapid progression, poor prognosis, and high risk of postoperative recurrence.
Wen Dong +14 more
doaj +1 more source