Results 71 to 80 of about 559,643 (344)
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Pregnant women exhibit decreased trigeminal sensitivity
Brain and BehaviorIntroduction Chemosensory function in pregnant women is far from being fully understood due to the lack of data and inconsistencies between the results of self‐reports and objective studies. Methods In the present study in pregnant and non‐pregnant women
Agnieszka Sabiniewicz +2 more
doaj +1 more source
Value Disgust: Appreciating Stench’s Role in Attention, Retention and Deception
Rivista di Estetica, 2021 Philosophers, moral psychologists and neuroscientists have written plenty about disgust as it concerns foul actions, revolting images and unsavory tastes. Far less has been written about stinky delicacies.
Sue Spaid
doaj +1 more source
, 2006 The ocean's distinctive smell is caused by a single chemical released by plankton and other marine life, dimethyl sulphide (DMS). A study by a group of investigators from the University of Groningen used a technique called laser-sheet particle image ...
Steinke, M
core
Psychic euosmia and obsessive compulsive personality disorder [PDF]
, 2018 Patients with obsessive compulsive personality disorder (OCPD) often refer to a prompt mood improvement upon encountering good scents in general, or fresh laundry borax on their clothes, pillows or home settings.
Maraone, Annalisa +3 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
How Reliably Misrepresenting Olfactory Experiences Justify True Beliefs [PDF]
, 2020 This chapter argues that olfactory experiences represent either everyday objects or ad hoc olfactory objects as having primitive olfactory properties, which happen to be uninstantiated.
Mendelovici, Angela
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
, 2015 Long-standing neglect of the chemical senses in the philosophy of perception is due, mostly, to their being regarded as ‘lower’ senses. Smell, taste, and chemically irritated touch are thought to produce mere bodily sensations ...
Smith, Barry C.
core
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source