Results 61 to 70 of about 178,519 (305)

Pregnant women exhibit decreased trigeminal sensitivity

Brain and Behavior
Introduction Chemosensory function in pregnant women is far from being fully understood due to the lack of data and inconsistencies between the results of self‐reports and objective studies. Methods In the present study in pregnant and non‐pregnant women
Agnieszka Sabiniewicz, Michał Pieniak, Thomas Hummel   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Relationship Between Nasal Trigeminal Receptor Expression and Trigeminal Sensitivity

OTO Open
An intact intranasal trigeminal function is crucial for chemosensory and somatosensory perception, environmental irritation detection, and triggering protective reflexes. Accurately assessing intranasal trigeminal function is thus essential.
Akshita Joshi, Yiling Mai, Susanne Füssel, Thomas Hummel   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Granulocyte Colony Stimulating Factor (G‐CSF) and Olfactory Function—A Clinical Pilot Study

Laryngoscope Investigative Otolaryngology
Background Although the olfactory epithelium, including its neuronal cell line, has inherent regenerative potential, therapeutic options remain limited.
C. A. Hintschich, K. Resler, C. Brückner, A. Altundag, K. Trautmann, K. Hölig, F. Kroschinsky, M. Pieniak, T. Hummel   +8 more
doaj   +1 more source

Code smells

CoRR, 2018
Code smells as symptoms of poor design and implementation choices. Many times they are the result of so called technical debt. Our study showed that the interest in code smells research is increasing. However, most of the publications are appearing in conference proceedings. Most of the research is done in G7 and other highly developed countries.
Peter Kokol, Milan Zorman, Grega Zlahtic, Bojan Zlahtic   +3 more
openaire   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Effects of functional endoscopic sinus surgery on olfactory and trigeminal function in chronic rhinosinusitis with nasal polyps

Scientific Reports
Chronic rhinosinusitis (CRS) with and without nasal polyps has a prevalence of around 10%, being one of the most common chronic diseases in Europe. It is characterized by a wide range of symptoms leading to a high individual, clinical and socioeconomic ...
Arianna Soncini, Kwangsu Kim, Fabian Herfort, Coralie Mignot, Antje Haehner, Thomas Hummel   +5 more
doaj   +1 more source