Results 51 to 60 of about 158,325 (313)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári +6 morewiley +1 more sourceRecovery from smell loss [PDF]
, 2021 Loss or impaired sense of smell is a symptom of viral illnesses, including the common cold (Pellegrino et al., 2017) and SARS-CoV-2 (Gerkin et al., 2020; Pellegrino et al., 2020), sinonasal disease (Dalton, 2004), traumatic brain injury (Collet et al ...Pamela Dalton, Valentina Parma, Stephanie Hunter, Robert Pellegrino +3 morecore +1 more sourceMore than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis [PDF]
, 2020 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and Ferdenzi C., Schöpf, V., Faraji F., Smith , Barry C, Navarro M., Pepino, Marta Y, Farruggia, Michael,, Colquitt, L. R., Fjaeldstad A. W., Yoluk, N., Olofsson, Jonas, Bakke, Alyssa J., Bakke, Alyssa J, Veldhuizen, M.G., Sell, Elizabeth, Patel, Zara M, Niv, M. Y., Cooper, Keiland, W, Huart, Caroline, Mariño, Sajidxa, Bakke A. J., Kelly, C.E., Morini, G., Mariño, S., Philpott, Carl M, D’Errico, A., Ritchie M., Alizadeh R., Menini, A., Klein, Hadar, Meyer , Pablo, Patel Z. M., Hummel , Thomas, Lundström, Johan N, Pizio, Antonella,, Jalessi, M., Dibattista, Michele, Pirastu N., Fischmeister, F. P. S., Fredborg, William E. A., Munger, S. D., Navarro, Marta, Hummel, Thomas, Di Pizio, A., Walsh-Messinger, Julie, Fiorucci, S., Olsson, S. B., Pizio, Antonella, Di, Farruggia, M. C., Schopf V., Soler G. M., Pereda-Loth V., Boesveldt S., Archer, Nicholas, Okamoto, Masako, de Groot, Jasper H. B., Sandell M., Saatci O., Saraiva, Luis,, Bakke, Alyssa, J, Hayes, J.E., Veldhuizen, Maria, G, Yanik, Hüseyin, Rohlfs Domínguez, Paloma, Bhutani S., Fjaeldstad, Alexander W, GCCR Group Author, Heinbockel, T., Croijmans, Ilja, Abdulrahman, Olagunju, Saraiva, L. R., Archer, Nicholas S, de Groot J. H. B., Nolden, Alissa A., Huart , Caroline, Fredborg, William, E A, Reed D. R., Santamaría , Enrique, Liuzza, Marco, Colquitt , Lauren R, Gerkin, R. C., ?, ?, Colquitt, Lauren R, Archer, N. S., Shields, Vonnie D C, Kumar, Ritesh, Fischmeister , Florian Ph S, Olofsson, J. K., Santamaría, E., Restrepo, D., Morini, Gabriella, Whitcroft, K, L, Ozdener M. H., Justice, Jeb, Pepino M. Y., Alwashahi, Mohammed K., Fischmeister F. P. S., Bensafi, M., Malnic, B., Hayes, J. E, Meyer P., Alwashahi, Mohammed, K, Fiorucci, Sébastien, Van Den Brink, Mirjam; id_orcid, Chen, Jingguo, Alwashahi, Mohammed, Mucignat C., Shields, V. D. C., Fredborg, W. E. A., Fischmeister, Florian Ph S., Freiherr, Jessica, Thomas-Danguin, T., Reed, Danielle, R., Smith, B. C., Öztürk, Lina, Olofsson, Jonas,, Mazal, P. P., Yanık, Hüseyin, Shields, Vonnie DC, Veldhuizen M. G., Margulis, Eitan, Lundström, Johan,, Brindha, Evelyn, Nováková , Lenka Martinec, Thomas-Danguin, Thierry, Boesveldt, S., Justice, J. M., Whitcroft, Katherine L, Freiherr, J., Dibattista, M., Philpott, Carl,, Veldhuizen, Maria,, Lim, Juyun, Ozdener, M. H., Mignot, C., Georgiev, D., Fischmeister, Florian Ph S, Malnic, Bettina, Smith B. C., Fischmeister, Florian, Reed, D. R., Kaur, Rishemjit, Chen, Ben, Razzaghi-Asl, Sara, Schmuker M., Fredborg, William, Chen , Ben, Liuzza, M. T., Gerkin , Richard C, Frasnelli, Johannes, Colquitt, Lauren R., Niv, Masha Y., Fredborg, William E. A.,, Hayes, John E, Bensafi, Moustafa, Menini , Anna, Schmuker , Michael, Mignot, Coralie, Olsson, Shannon,, Rohlfs Domínguez, P., Parker, Jane K., Frasnelli J., Di Pizio, Antonella, Munger, Steven D., Kaur R., Bano Singh , Preet, Ritchie, M., Hayes , John E, Reed, Danielle R, Bakke, A.J., Lundström, Johan, N., Olofsson , Jonas K, Philpott, Carl M., Singh, Preet Bano, Kelly, Christine, Pepino, Marta Y., Olofsson, Jonas K, Roura E., Hsieh, Julien W, Bakke, Alyssa,, Chen, J., Fjaeldstad, Alexander,, Lundström, J. N., Konstantinidis I., Saatci, Ö., Hwang, Liang Dar, Konstantinidis, I., Gerkin R. C., Albayay J., Fjaeldstad, Alexander, W, Fredborg, William EA, Whitcroft K. L., Schoepf, Veronika, Welge-Lussen, Antje, Seyed-Allaei, Shima, Brindha, Evelyn V., Shields, Vonnie,, Ferdenzi, Camille, Lim, J., Kumar R., Group, Gccr, Hsieh J. W., Fjaeldstad, A. W., van den Brink, Mirjam, Munger, S.D., Ferdenzi, C., Voznessenskaya, Vera V, Veldhuizen, MK, Nunez-Parra A., Philpott , Carl M, Laudamiel, Christophe, Saatci, Özlem, Moein, Shima, Walsh-Messinger, J., Razzaghi-Asl, S., Guardia M. D., Munger, Steven D, Saraiva, Luis R., Guàrdia, M. D., Fiorucci S., Parma, V., Patel, Z. M., Pepino, Marta,, Bakke , Alyssa J, Parker , Jane K, Fischmeister, Florian,, Pierron, Denis, Bensafi, Moustafa, Smith, Barry, Schöpf , Veronika, Shields V. D. C., Parker, J. K., Bouysset , Cédric, Altundag A., Niv, Masha Y, Macchi, Alberto, Fredborg , William E A, Olofsson J. K., Nuñez Parra, Alexia, Faraji, F., Soler, G. M., Alizadeh, R., Kelly, C. E., Mucignat , Carla, Santamaria, Enrique, Hayes, John, E., Nunez-Parra, Alexia, Reed, Danielle,, Olsson, Shannon B, Whitcroft , Katherine L, D'Errico A., Niv, Masha, Okamoto, M., Santamaria E., Albayay, Javier, Yanık, H., Guàrdia, Maria Dolors, Pierron, D., Parker J. K., Croijmans, I., Colquitt, Lauren, R, Golebiowski, Jérôme, Liuzza M. T., Ozdener, Mehmet Hakan, Hwang, Liang-Dar, Lundstrom, Johan N., Olsson S. B., Munger S. D., Huart C., Pepino , Marta Y, Konstantinidis, Iordanis, Gerkin, Richard, C, Altundag, Aytug, Sell, Elizabeth A, Genovese, F., Dominguez, Paloma Rohlfs, Macchi A., van den Brink M., Pereda-Loth, V., Niv, M.Y., Shields, Vonnie, Dolors Guardia, Maria, Colquitt, Lauren,, Brindha E. V., Nováková, Lenka Martinec, Menini A., Hayes, John E., Pellegrino, Robert, Roura, Eugeni, Justice, Jeb M, Veldhuizen , Maria G, Olsson, Shannon B., Whitcroft, Katherine, L, Welge-Lussen A., Menini, Anna, Munger , Steven D, de Groot, Jasper, Patel, Zara,, Morini G., Havlicek J., Bouysset, C., Ohla, K., Gerkin, Richard C, Roberts, S Craig, Freiherr J., Whitcroft, Katherine L., Brindha, Evelyn, V, Olofsson, Jonas K.,, de Groot, Jasper H B, Voznessenskaya, Vera, Munger, Steven, Nunez-Parra, A., Cooper K. W., Patel, Zara M., Meyer, P., Thomas Danguin, Thierry, Alizadeh , Rafieh, de Groot, J. H. B., Whitcroft, K L, Öztürk, L., Brindha, E. V., Schmuker, M., Chen, B., Smith, Barry C., Havlícek, Jan, Liuzza, Marco Tullio, Ozturk L., Cooper, Keiland W., Sandell, M., Reed , Danielle R, Parma V., Roura, Eugenie, Farruggia, Michael, C, Hayes, John,, Saraiva, Luis, R, Pepino, Marta, y, Singh, P. B., Kaushik, P. K., Philpott, Carl, M, Kaushik, Pavan K, Reed, Danielle R., Genovese F., Hsieh, Julien, Welge-Lüssen , Antje, Abdulrahman, O., Boesveldt , Sanne, Soler , Graciela M, Huart, C., Nolden, Alissa,, Hwang, L. -D., Mucignat, C., de Groot, Jasper HB, Groot, J.H.B. de, Soler, Graciela, M, Morini , Gabriella, Saraiva L. R., Colquitt L. R., Okamoto M., Voznessenskaya, V. V., Pellegrino , Robert, Albayrak, Samet, Yan, C. H., Niv M. Y., Faraji , Farhoud, Cooper , Keiland W, Mucignat, Carla, Bensafi M., Yan, Carol, Ritchie, Marina, Rohlfs Dominguez P., Albayay, J., Lundström, Johan, Koyama, Sachiko, D’Errico, Anna, Fredborg, William,, Pereda Loth, Verónica, Heinbockel T., Roura, E., Cooper, K. W., Soler, Graciela M., Chen B., Nolden A. A., Veldhuizen, M. G., Alizadeh, Rafieh, Pellegrino, R., Philpott, C. M., Hummel, T., Welge Lussen, Antje, Bouysset C., Sandell, Mari, Nolden, A. A., Dibattista , Michele, Hsieh, J. W., Karni, Noam, Pirastu, N., Whitcroft, Katherine,, Bhutani, Surabhi, Lundstrom J. N., Hayes III, J.E., Karni N., Cooper, Keiland W, Olofsson, Jonas K., Thomas-Danguin T., Hayes J. E., Frasnelli, J., Olofsson, Jonas, K, Lin, C., Soler, Graciela, Moein, S. T., Kaushik, Pavan, Fjaeldstad, Alexander W., Georgiev, Dejan, Dar Hwang, Liang-, Pierron D., Hwang L. -D., Saraiva, Luis R, Saatci , Özlem, Brindha, Evelyn,, Pereda-Loth, Veronica, Faraji, Farhoud, Welge-Lüssen, A., Klein, H., Deary, V., Heinbockel, Thomas, Wang, Hong, Jülich, Forschungszentrum, Hsieh , Julien W, Philpott C. M., Kelly, Christine E, Lin, Cailu, Olsson, Shannon, B, Parma, Valentina, Schmuker, Michael, Fredborg, William E A, Niv , Masha Y, Alwashahi M. K., Klein H., Sell, E. A., Ohla, Kathrin, Fjaeldstad , Alexander W, Kelly C. E., Ozdener, Hakan, Laudamiel C., Alwashahi, M. K., Macchi, A., Pellegrino R., Nováková, L. M., Bouysset, Cédric, Fischmeister, Florian, Ph S, Parker, Jane, Gerkin, Richard C., Bakke, A. J., Frasnelli , Johannes, Mazal, Patricia Portillo, Laudamiel, C., Nolden, Alissa A, Alwashahi, Mohammed K, Shields , Vonnie D C, Dalton, Pamela, Karni, N., Lim J., Kelly , Christine E, Farruggia M. C., Singh P. B., Gerkin, Richard,, Koyama, S., Restrepo, Diego, van den Brink, M., Bhutani, S., Soler, Graciela,, Margulis, E., Yoluk, Nur, Kaur, R., Dalton, P., Havlícek, J., Shields, Vonnie, D C, Veldhuizen, Maria G, Cooper, Keiland,, Golebiowski J., Kelly, Christine E., Group Author, GCCR, Pepino, M. Y., Boesveldt, Sanne, Meyer, Pablo, Seyed-Allaei, S., Farruggia, Michael C., Nolden, Alissa, A, Jalessi M., Hsieh, Julien W., Patel, Zara, M, Navarro, M., Ritchie , Marina, Soler, Graciela M, Parker, Jane K, Whitcroft, K. L., Deary, Vincent, Wang, H., d'Errico, Anna, Fredborg W. E. A., Brindha, Evelyn V, Maachi, Alberto, Genovese, Federica, Dibattista M., Ohla K., Veldhuizen, Maria G., Moein, Shima T, Whitcroft, K,, Pirastu, Nicola, Yan, Carol H, Jalessi, Maryam, Farruggia, Michael C, Alwashahi, Mohammed,, Di Pizio A., Roberts, S. C., Albayrak, S., Smith, Barry C, de Groot , Jasper H B, Lin C., Altundag, A., Hummel T., Kumar, R., Whitcroft, KL, Schöpf, Veronika, Shields, Vonnie D. C., Golebiowski, J. +524 morecore +1 more sourceReconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...Lukas Drexler, Markus R. Busch, Reinhard Sterner +2 morewiley +1 more sourceSMELL [PDF]
, 2023 Although somewhat marginal in relation to the other senses, smell is the most potent way of anchoring ourselves to the world. We subconsciously find our place in it by sniffing our body, the body of the one next to us, the room in which we are, the ...core +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more source
