Results 31 to 40 of about 152,111 (264)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...Xuelang Mu, Ampon Sae Her, Tamir Gonenwiley +1 more sourceMore than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis [PDF]
, 2020 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and Ferdenzi C., Schöpf, V., Faraji F., Smith , Barry C, Navarro M., Pepino, Marta Y, Farruggia, Michael,, Colquitt, L. R., Fjaeldstad A. W., Yoluk, N., Olofsson, Jonas, Bakke, Alyssa J., Bakke, Alyssa J, Veldhuizen, M.G., Sell, Elizabeth, Patel, Zara M, Niv, M. Y., Cooper, Keiland, W, Huart, Caroline, Mariño, Sajidxa, Bakke A. J., Kelly, C.E., Morini, G., Mariño, S., Philpott, Carl M, D’Errico, A., Ritchie M., Alizadeh R., Menini, A., Klein, Hadar, Meyer , Pablo, Patel Z. M., Hummel , Thomas, Lundström, Johan N, Pizio, Antonella,, Jalessi, M., Dibattista, Michele, Pirastu N., Fischmeister, F. P. S., Fredborg, William E. A., Munger, S. D., Navarro, Marta, Hummel, Thomas, Di Pizio, A., Walsh-Messinger, Julie, Fiorucci, S., Olsson, S. B., Pizio, Antonella, Di, Farruggia, M. C., Schopf V., Soler G. M., Pereda-Loth V., Boesveldt S., Archer, Nicholas, Okamoto, Masako, de Groot, Jasper H. B., Sandell M., Saatci O., Saraiva, Luis,, Bakke, Alyssa, J, Hayes, J.E., Veldhuizen, Maria, G, Yanik, Hüseyin, Rohlfs Domínguez, Paloma, Bhutani S., Fjaeldstad, Alexander W, GCCR Group Author, Heinbockel, T., Croijmans, Ilja, Abdulrahman, Olagunju, Saraiva, L. R., Archer, Nicholas S, de Groot J. H. B., Nolden, Alissa A., Huart , Caroline, Fredborg, William, E A, Reed D. R., Santamaría , Enrique, Liuzza, Marco, Colquitt , Lauren R, Gerkin, R. C., ?, ?, Colquitt, Lauren R, Archer, N. S., Shields, Vonnie D C, Kumar, Ritesh, Fischmeister , Florian Ph S, Olofsson, J. K., Santamaría, E., Restrepo, D., Morini, Gabriella, Whitcroft, K, L, Ozdener M. H., Justice, Jeb, Pepino M. Y., Alwashahi, Mohammed K., Fischmeister F. P. S., Bensafi, M., Malnic, B., Hayes, J. E, Meyer P., Alwashahi, Mohammed, K, Fiorucci, Sébastien, Van Den Brink, Mirjam; id_orcid, Chen, Jingguo, Alwashahi, Mohammed, Mucignat C., Shields, V. D. C., Fredborg, W. E. A., Fischmeister, Florian Ph S., Freiherr, Jessica, Thomas-Danguin, T., Reed, Danielle, R., Smith, B. C., Öztürk, Lina, Olofsson, Jonas,, Mazal, P. P., Yanık, Hüseyin, Shields, Vonnie DC, Veldhuizen M. G., Margulis, Eitan, Lundström, Johan,, Brindha, Evelyn, Nováková , Lenka Martinec, Thomas-Danguin, Thierry, Boesveldt, S., Justice, J. M., Whitcroft, Katherine L, Freiherr, J., Dibattista, M., Philpott, Carl,, Veldhuizen, Maria,, Lim, Juyun, Ozdener, M. H., Mignot, C., Georgiev, D., Fischmeister, Florian Ph S, Malnic, Bettina, Smith B. C., Fischmeister, Florian, Reed, D. R., Kaur, Rishemjit, Chen, Ben, Razzaghi-Asl, Sara, Schmuker M., Fredborg, William, Chen , Ben, Liuzza, M. T., Gerkin , Richard C, Frasnelli, Johannes, Colquitt, Lauren R., Niv, Masha Y., Fredborg, William E. A.,, Hayes, John E, Bensafi, Moustafa, Menini , Anna, Schmuker , Michael, Mignot, Coralie, Olsson, Shannon,, Rohlfs Domínguez, P., Parker, Jane K., Frasnelli J., Di Pizio, Antonella, Munger, Steven D., Kaur R., Bano Singh , Preet, Ritchie, M., Hayes , John E, Reed, Danielle R, Bakke, A.J., Lundström, Johan, N., Olofsson , Jonas K, Philpott, Carl M., Singh, Preet Bano, Kelly, Christine, Pepino, Marta Y., Olofsson, Jonas K, Roura E., Hsieh, Julien W, Bakke, Alyssa,, Chen, J., Fjaeldstad, Alexander,, Lundström, J. N., Konstantinidis I., Saatci, Ö., Hwang, Liang Dar, Konstantinidis, I., Gerkin R. C., Albayay J., Fjaeldstad, Alexander, W, Fredborg, William EA, Whitcroft K. L., Schoepf, Veronika, Welge-Lussen, Antje, Seyed-Allaei, Shima, Brindha, Evelyn V., Shields, Vonnie,, Ferdenzi, Camille, Lim, J., Kumar R., Group, Gccr, Hsieh J. W., Fjaeldstad, A. W., van den Brink, Mirjam, Munger, S.D., Ferdenzi, C., Voznessenskaya, Vera V, Veldhuizen, MK, Nunez-Parra A., Philpott , Carl M, Laudamiel, Christophe, Saatci, Özlem, Moein, Shima, Walsh-Messinger, J., Razzaghi-Asl, S., Guardia M. D., Munger, Steven D, Saraiva, Luis R., Guàrdia, M. D., Fiorucci S., Parma, V., Patel, Z. M., Pepino, Marta,, Bakke , Alyssa J, Parker , Jane K, Fischmeister, Florian,, Pierron, Denis, Bensafi, Moustafa, Smith, Barry, Schöpf , Veronika, Shields V. D. C., Parker, J. K., Bouysset , Cédric, Altundag A., Niv, Masha Y, Macchi, Alberto, Fredborg , William E A, Olofsson J. K., Nuñez Parra, Alexia, Faraji, F., Soler, G. M., Alizadeh, R., Kelly, C. E., Mucignat , Carla, Santamaria, Enrique, Hayes, John, E., Nunez-Parra, Alexia, Reed, Danielle,, Olsson, Shannon B, Whitcroft , Katherine L, D'Errico A., Niv, Masha, Okamoto, M., Santamaria E., Albayay, Javier, Yanık, H., Guàrdia, Maria Dolors, Pierron, D., Parker J. K., Croijmans, I., Colquitt, Lauren, R, Golebiowski, Jérôme, Liuzza M. T., Ozdener, Mehmet Hakan, Hwang, Liang-Dar, Lundstrom, Johan N., Olsson S. B., Munger S. D., Huart C., Pepino , Marta Y, Konstantinidis, Iordanis, Gerkin, Richard, C, Altundag, Aytug, Sell, Elizabeth A, Genovese, F., Dominguez, Paloma Rohlfs, Macchi A., van den Brink M., Pereda-Loth, V., Niv, M.Y., Shields, Vonnie, Dolors Guardia, Maria, Colquitt, Lauren,, Brindha E. V., Nováková, Lenka Martinec, Menini A., Hayes, John E., Pellegrino, Robert, Roura, Eugeni, Justice, Jeb M, Veldhuizen , Maria G, Olsson, Shannon B., Whitcroft, Katherine, L, Welge-Lussen A., Menini, Anna, Munger , Steven D, de Groot, Jasper, Patel, Zara,, Morini G., Havlicek J., Bouysset, C., Ohla, K., Gerkin, Richard C, Roberts, S Craig, Freiherr J., Whitcroft, Katherine L., Brindha, Evelyn, V, Olofsson, Jonas K.,, de Groot, Jasper H B, Voznessenskaya, Vera, Munger, Steven, Nunez-Parra, A., Cooper K. W., Patel, Zara M., Meyer, P., Thomas Danguin, Thierry, Alizadeh , Rafieh, de Groot, J. H. B., Whitcroft, K L, Öztürk, L., Brindha, E. V., Schmuker, M., Chen, B., Smith, Barry C., Havlícek, Jan, Liuzza, Marco Tullio, Ozturk L., Cooper, Keiland W., Sandell, M., Reed , Danielle R, Parma V., Roura, Eugenie, Farruggia, Michael, C, Hayes, John,, Saraiva, Luis, R, Pepino, Marta, y, Singh, P. B., Kaushik, P. K., Philpott, Carl, M, Kaushik, Pavan K, Reed, Danielle R., Genovese F., Hsieh, Julien, Welge-Lüssen , Antje, Abdulrahman, O., Boesveldt , Sanne, Soler , Graciela M, Huart, C., Nolden, Alissa,, Hwang, L. -D., Mucignat, C., de Groot, Jasper HB, Groot, J.H.B. de, Soler, Graciela, M, Morini , Gabriella, Saraiva L. R., Colquitt L. R., Okamoto M., Voznessenskaya, V. V., Pellegrino , Robert, Albayrak, Samet, Yan, C. H., Niv M. Y., Faraji , Farhoud, Cooper , Keiland W, Mucignat, Carla, Bensafi M., Yan, Carol, Ritchie, Marina, Rohlfs Dominguez P., Albayay, J., Lundström, Johan, Koyama, Sachiko, D’Errico, Anna, Fredborg, William,, Pereda Loth, Verónica, Heinbockel T., Roura, E., Cooper, K. W., Soler, Graciela M., Chen B., Nolden A. A., Veldhuizen, M. G., Alizadeh, Rafieh, Pellegrino, R., Philpott, C. M., Hummel, T., Welge Lussen, Antje, Bouysset C., Sandell, Mari, Nolden, A. A., Dibattista , Michele, Hsieh, J. W., Karni, Noam, Pirastu, N., Whitcroft, Katherine,, Bhutani, Surabhi, Lundstrom J. N., Hayes III, J.E., Karni N., Cooper, Keiland W, Olofsson, Jonas K., Thomas-Danguin T., Hayes J. E., Frasnelli, J., Olofsson, Jonas, K, Lin, C., Soler, Graciela, Moein, S. T., Kaushik, Pavan, Fjaeldstad, Alexander W., Georgiev, Dejan, Dar Hwang, Liang-, Pierron D., Hwang L. -D., Saraiva, Luis R, Saatci , Özlem, Brindha, Evelyn,, Pereda-Loth, Veronica, Faraji, Farhoud, Welge-Lüssen, A., Klein, H., Deary, V., Heinbockel, Thomas, Wang, Hong, Jülich, Forschungszentrum, Hsieh , Julien W, Philpott C. M., Kelly, Christine E, Lin, Cailu, Olsson, Shannon, B, Parma, Valentina, Schmuker, Michael, Fredborg, William E A, Niv , Masha Y, Alwashahi M. K., Klein H., Sell, E. A., Ohla, Kathrin, Fjaeldstad , Alexander W, Kelly C. E., Ozdener, Hakan, Laudamiel C., Alwashahi, M. K., Macchi, A., Pellegrino R., Nováková, L. M., Bouysset, Cédric, Fischmeister, Florian, Ph S, Parker, Jane, Gerkin, Richard C., Bakke, A. J., Frasnelli , Johannes, Mazal, Patricia Portillo, Laudamiel, C., Nolden, Alissa A, Alwashahi, Mohammed K, Shields , Vonnie D C, Dalton, Pamela, Karni, N., Lim J., Kelly , Christine E, Farruggia M. C., Singh P. B., Gerkin, Richard,, Koyama, S., Restrepo, Diego, van den Brink, M., Bhutani, S., Soler, Graciela,, Margulis, E., Yoluk, Nur, Kaur, R., Dalton, P., Havlícek, J., Shields, Vonnie, D C, Veldhuizen, Maria G, Cooper, Keiland,, Golebiowski J., Kelly, Christine E., Group Author, GCCR, Pepino, M. Y., Boesveldt, Sanne, Meyer, Pablo, Seyed-Allaei, S., Farruggia, Michael C., Nolden, Alissa, A, Jalessi M., Hsieh, Julien W., Patel, Zara, M, Navarro, M., Ritchie , Marina, Soler, Graciela M, Parker, Jane K, Whitcroft, K. L., Deary, Vincent, Wang, H., d'Errico, Anna, Fredborg W. E. A., Brindha, Evelyn V, Maachi, Alberto, Genovese, Federica, Dibattista M., Ohla K., Veldhuizen, Maria G., Moein, Shima T, Whitcroft, K,, Pirastu, Nicola, Yan, Carol H, Jalessi, Maryam, Farruggia, Michael C, Alwashahi, Mohammed,, Di Pizio A., Roberts, S. C., Albayrak, S., Smith, Barry C, de Groot , Jasper H B, Lin C., Altundag, A., Hummel T., Kumar, R., Whitcroft, KL, Schöpf, Veronika, Shields, Vonnie D. C., Golebiowski, J. +524 morecore +1 more sourceModulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári +6 morewiley +1 more sourceSMELL [PDF]
, 2023 Although somewhat marginal in relation to the other senses, smell is the most potent way of anchoring ourselves to the world. We subconsciously find our place in it by sniffing our body, the body of the one next to us, the room in which we are, the ...core +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more source
