Results 71 to 80 of about 2,634,989 (242)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Maestros narrados en el cine.Una mirada entreabierta sobre la escuela, el saber y la formación (Teachers in Cinema. A Half-open Perspective of Schools, Knowledge and Education) (Mestres narrados no cinema. Um olhar entreaberto sobre a escola, o saber e a formação)(Maîtres narrateurs dans le cinéma. Un regard entrouvert sur l′école, le savoir et la formation) [PDF]

Magis: Revista Internacional de Investigación en Educación, 2011
ResumenEl texto realiza una reflexión pedagógica a partir de tres producciones cinematográficas, a saber, Estrellas del cielo sobre la tierra, Rojo como el cie- lo y La sonrisa de Mona Lisa.
Érica Elexandra Areiza-Pérez, Diela Bibiana Betancur-Valencia   +1 more
doaj  

Comparative evaluation of artificial intelligence-assisted smile designs: Aesthetic preferences among dental specialists and laypeople.

Journal of Prosthodontics
PURPOSE To evaluate aesthetic preferences for artificial intelligence (AI)-assisted smile designs produced using four digital smile design software platforms, and to explore associations between these preferences and demographic factors, among dental ...
G. Alsulaiman, R. Baaj, Rasha Altahan
semanticscholar   +1 more source

Architecture‐Engineered Semi‐Crystalline Microporous Polymer Membranes for Precise Molecular Separation

Advanced Science, EarlyView.
Guided by a Random Forest model, a π–π‐driven ordered stacking strategy deploys functionally distinct substructures to restrict chain segment motion and increase free volume, while preserving the intermolecular interactions that maintain structural integrity.
Zi‐Meng Xu, Hao Zhuo, Song‐Hui Zhi, Xiao‐Feng Zhong, Pan‐Pan Zhang, Si‐Yuan Yang, Wen‐Yong Yang, Guang‐Yong Shen, Ya‐Zhao Li, Yi Li, Ming Xue   +10 more
wiley   +1 more source

Severely Full-Arch Deep Overbite Treated With Clear Aligners

International Dental Journal
Introduction: Deep overbite treatment has always been a challenge in orthodontics, especially for full-arch deep overbite cases. Traditional fixed orthodontic methods achieve better results, but they often compromise comfort and aesthetics, leading to a ...
Xu Anxiu, Xie Bingjie
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Interest rate convexity and the volatility smile [PDF]

When pricing the convexity effect in irregular interest rate derivatives such as, e.g., Libor-in-arrears or CMS, one often ignores the volatility smile, which is quite pronounced in the interest rate options market.
Boenkost, Wolfram, Schmidt, Wolfgang M.
core  

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Proteomic analysis reveals key differences in pro-stromal corneal tissue between highly myopic males and females

Frontiers in Medicine
Background and purpose Nowadays, myopia has become a highly prevalent disease globally, especially in East Asia. Epidemiological studies have found that there may be sex differences in the occurrence and progression of myopia, with females having a ...
G. Cui, Yu-Lan Di, Shan Yang, Youxin Chen, Ying Li, Di Chen   +5 more
semanticscholar   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source