Results 81 to 90 of about 2,634,989 (242)

BOOK REVIEW Cesty k literatuře: Podněty pro literární vzdělávání [Paths to Literature: Inspirations for Literary Education]

SKASE Journal of literary and cultural studies
The quotation by Comenius with which Tomáš Jajtner concludes his essay collection Cesty k literatuře: Podněty pro literární vzdělávání [Paths to Literature: Inspirations for Literary Education] might raise an ironic or even bitter smile on the lips of ...
Soňa Šnircová
semanticscholar   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

The outcomes of first-generation (visumax 500) and second-generation (Visumax 800) keratorefractive lenticule extraction surgeries for astigmatism

Scientific Reports
To evaluate the efficiency, predictability, and residual astigmatism between first- and second-generation keratorefractive lenticule extraction (KLEx) surgeries in a prominent astigmatism population.
Chia-Yi Lee, Le-Bin Lian, Hung-Chi Chen, Chin-Te Huang, Jing-Yang Huang, Shun-Fa Yang, Chao-Kai Chang   +6 more
doaj   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

ZrCo3B2 and HfCo3B2 Electrodes Go on Stage for Oxygen Evolution Reaction

Advanced Science, EarlyView.
The intermetallic compounds ZrCo3B2 and HfCo3B2 with distinctive chemical bonding features are excellent OER precursors, restructuring into OER‐active electrocatalysts delivering significantly high OER activities compared to the elemental Co, which is obvious from their lower onset potentials and increased obtained current densities.
Fatma Aras, Ulrich Burkhardt, Simone G. Altendorf, Yuri Grin, Iryna Antonyshyn   +4 more
wiley   +1 more source

Comparing the Existing Myopic Keratorefractive Lenticule Extraction (KLEx) Platforms: A Narrative Review [Response to Letter]

Clinical Ophthalmology
Sabrina M Miller,1,* Mina M Sitto,2,3,* Kayvon A Moin,2,4 Phillip C Hoopes,2 Majid Moshirfar2,5,6 1Department of Neurology and Ophthalmology, Michigan State University College of Osteopathic Medicine, East Lansing, MI, USA; 2Hoopes ...
Miller SM, Sitto MM, Moin KA, Hoopes PC, Moshirfar M   +4 more
doaj  

dan11mcguire/smile: v1.1.0

<p>Code for fitting SMILE models.</p ...
dan11mcguire
core   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Descriptor‐Guided Computational Screening of Non‐Fullerene Acceptor Cores for Organic Solar Cells

Advanced Energy Materials, EarlyView.
We screen over 4000 non‐fullerene acceptors using their ionization energy, electron affinity, quadrupole, and dipole moments to select the top‐ten candidates for a given donor polymer. The workflow recovers known high‐performance motifs and reveals how molecular components influence material properties.
Kun‐Han Lin, J. Terence Blaskovits, Wenlan Liu, Shu‐Yi Hu, Kuei‐Jhong Lin, Sandeep Sharma, Julien Gorenflot, Martin Heeney, Frédéric Laquai, Denis Andrienko   +9 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source