Results 11 to 20 of about 634,846 (172)

Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. [PDF]

PLoS ONE, 2015
The SMN-Gemins complex is composed of Gemins 2-8, Unrip and the survival motor neuron (SMN) protein. Limiting levels of SMN result in the neuromuscular disorder, spinal muscular atrophy (SMA), which is presently untreatable.
Rebecca M Borg, Rémy Bordonne, Neville Vassallo, Ruben J Cauchi   +3 more
doaj   +2 more sources

Pseudophosphorylated αB-crystallin is a nuclear chaperone imported into the nucleus with help of the SMN complex. [PDF]

PLoS ONE, 2013
The human small heat shock protein αB-crystallin (HspB5) is a molecular chaperone which is mainly localized in the cytoplasm. A small fraction can also be found in nuclear speckles, of which the localization is mediated by successional phosphorylation at
John den Engelsman, Chantal van de Schootbrugge, Jeongsik Yong, Ger J M Pruijn, Wilbert C Boelens   +4 more
doaj   +2 more sources

Oligomerization regulates the interaction of Gemin5 with members of the SMN complex and the translation machinery

Cell Death Discovery
RNA-binding proteins are multifunctional molecules impacting on multiple steps of gene regulation. Gemin5 was initially identified as a member of the survival of motor neurons (SMN) complex.
Rosario Francisco-Velilla, Salvador Abellan, Azman Embarc-Buh, Encarnacion Martinez-Salas   +3 more
doaj   +2 more sources

Anti-survival of motor neuron antibodies in rheumatic and musculoskeletal diseases: prevalence, clinical associations, and biomarker potential, with novel insights into disease activity in SLE [PDF]

Inflammation and Regeneration
Background Anti-survival of motor neuron (SMN) antibodies have recently been identified in rheumatic and musculoskeletal diseases (RMDs), notably mixed connective tissue disease (MCTD).
Yuki Imai, Masaru Takeshita, Koji Suzuki, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
doaj   +2 more sources

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

eLife, 2016
The multi-domain splicing factor RBM5 regulates the balance between antagonistic isoforms of the apoptosis-control genes FAS/CD95, Caspase-2 and AID. An OCRE (OCtamer REpeat of aromatic residues) domain found in RBM5 is important for alternative splicing
André Mourão, Sophie Bonnal, Komal Soni, Lisa Warner, Rémy Bordonné, Juan Valcárcel, Michael Sattler   +6 more
doaj   +2 more sources

Tudor-based proteomic strategy pan-specifically enriches and identifies protein arginine methylation [PDF]

EMBO Reports
Protein arginine methylation is an important post-translational modification (PTM) in eukaryotes, regulating a variety of biological processes. Proteomic profiling of arginine methylation has advanced our understanding of its roles in biology and disease.
Lingzi Lu, Ting Li, Rou Zhang, Yutong Wang, Xiaoping Ye, Yixin Luo, Lingyu Sun, Liang Qi, Zilu Ye, Yang Mao, Yanqiu Yuan   +10 more
doaj   +2 more sources

The U1 snRNP-specific protein U1C is a key regulator of SMN complex-mediated snRNP formation. [PDF]

J Biol Chem
Ngu DM, Myti S, Khan AA, Keita J, Moore T, Andega P, Aziz A, Raj R, Johnson-Winters K, Suh EH, So BR.   +10 more
europepmc   +3 more sources

A unique mechanism of snRNP core assembly [PDF]

Nature Communications
The assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA, typically requiring essential assembly chaperones like the SMN complex, associated with spinal muscular atrophy (SMA). Strikingly, in
Yingzhi Wang, Xiaoshuang Chen, Xi Kong, Yunfeng Chen, Zixi Xiang, Yue Xiang, Yan Hu, Yan Hou, Shijie Zhou, Congcong Shen, Li Mu, Dan Su, Rundong Zhang   +12 more
doaj   +2 more sources

RNA-binding proteins in disease etiology: fragile X syndrome and spinal muscular atrophy. [PDF]

RNA
All RNAs exist in complexes (RNPs) with RNA-binding proteins (RBPs). Studies in my lab since the 1980s have identified, sequenced and characterized the major pre-mRNA- and mRNA-RBPs (hnRNPs/mRNPs), revealing RNA-binding domains and common features of ...
Dreyfuss G.
europepmc   +2 more sources

Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins [PDF]

Human Molecular Genetics, 2000
Gunter Meister
openalex   +2 more sources