Results 11 to 20 of about 634,846 (172)

Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. [PDF]

open access: yesPLoS ONE, 2015
The SMN-Gemins complex is composed of Gemins 2-8, Unrip and the survival motor neuron (SMN) protein. Limiting levels of SMN result in the neuromuscular disorder, spinal muscular atrophy (SMA), which is presently untreatable.
Rebecca M Borg   +3 more
doaj   +2 more sources

Pseudophosphorylated αB-crystallin is a nuclear chaperone imported into the nucleus with help of the SMN complex. [PDF]

open access: yesPLoS ONE, 2013
The human small heat shock protein αB-crystallin (HspB5) is a molecular chaperone which is mainly localized in the cytoplasm. A small fraction can also be found in nuclear speckles, of which the localization is mediated by successional phosphorylation at
John den Engelsman   +4 more
doaj   +2 more sources

Oligomerization regulates the interaction of Gemin5 with members of the SMN complex and the translation machinery

open access: yesCell Death Discovery
RNA-binding proteins are multifunctional molecules impacting on multiple steps of gene regulation. Gemin5 was initially identified as a member of the survival of motor neurons (SMN) complex.
Rosario Francisco-Velilla   +3 more
doaj   +2 more sources

Anti-survival of motor neuron antibodies in rheumatic and musculoskeletal diseases: prevalence, clinical associations, and biomarker potential, with novel insights into disease activity in SLE [PDF]

open access: yesInflammation and Regeneration
Background Anti-survival of motor neuron (SMN) antibodies have recently been identified in rheumatic and musculoskeletal diseases (RMDs), notably mixed connective tissue disease (MCTD).
Yuki Imai   +8 more
doaj   +2 more sources

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

open access: yeseLife, 2016
The multi-domain splicing factor RBM5 regulates the balance between antagonistic isoforms of the apoptosis-control genes FAS/CD95, Caspase-2 and AID. An OCRE (OCtamer REpeat of aromatic residues) domain found in RBM5 is important for alternative splicing
André Mourão   +6 more
doaj   +2 more sources

Tudor-based proteomic strategy pan-specifically enriches and identifies protein arginine methylation [PDF]

open access: yesEMBO Reports
Protein arginine methylation is an important post-translational modification (PTM) in eukaryotes, regulating a variety of biological processes. Proteomic profiling of arginine methylation has advanced our understanding of its roles in biology and disease.
Lingzi Lu   +10 more
doaj   +2 more sources

The U1 snRNP-specific protein U1C is a key regulator of SMN complex-mediated snRNP formation. [PDF]

open access: goldJ Biol Chem
Ngu DM   +10 more
europepmc   +3 more sources

A unique mechanism of snRNP core assembly [PDF]

open access: yesNature Communications
The assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA, typically requiring essential assembly chaperones like the SMN complex, associated with spinal muscular atrophy (SMA). Strikingly, in
Yingzhi Wang   +12 more
doaj   +2 more sources

RNA-binding proteins in disease etiology: fragile X syndrome and spinal muscular atrophy. [PDF]

open access: yesRNA
All RNAs exist in complexes (RNPs) with RNA-binding proteins (RBPs). Studies in my lab since the 1980s have identified, sequenced and characterized the major pre-mRNA- and mRNA-RBPs (hnRNPs/mRNPs), revealing RNA-binding domains and common features of ...
Dreyfuss G.
europepmc   +2 more sources

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