Results 61 to 70 of about 33,891 (338)

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

An Analysis of Domestic Fire Smoke/Toxic Fumes Inhalation Injuries [PDF]

, 2023
Mark Taylor, Hulya Francis, John Fielding   +2 more
openalex   +1 more source

Management of acute smoke inhalation injury

Critical Care and Resuscitation, 2010
Pulmonary injury from smoke inhalation is common in burn victims, significantly contributing to the morbidity and mortality of fire-related injuries. The impacts of improvement in other aspects of burn care have not been mirrored in treatment of smoke inhalation.
Toon, Michael H., Maybauer, Marc O., Greenwood, John E., Maybauer, Dirk M., Fraser, John F.   +4 more
openaire   +2 more sources

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Health Effects Associated With Electronic Cigarette Use: Automated Mining of Online Forums. [PDF]

, 2020
BACKGROUND:Our previous infodemiological study was performed by manually mining health-effect data associated with electronic cigarettes (ECs) from online forums.
Hristidis, Vagelis, Hua, My, Sadah, Shouq, Talbot, Prue   +3 more
core  

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression [PDF]

, 2010
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of proteases and antiproteases ...
A Babusyte, A Kode, A Papi, A Sebastian, A Sydbom, AP Rogerio, AW Boots, C Kandaswami, C Tabak, CJ Vlahos, D Nowak, DC Newcomb, EH Walker, G Agullo, GA Finlay, GW Peet, HJ Park, HS Deshmukh, HS Deshmukh, I Rahman, IC Walda, IK Demedts, J Robak, JA Conquer, JC Chen, JD Hasday, JH Vernooy, JW Hwang, K Ito, K Minamoto, K Ohnishi, KF Chung, KK Meja, L Biasutto, L Larsson, L Segura-Valdez, M Comalada, M Harwood, M Ichinose, M Kasielski, M Suzuki, MK Hwang, MM Mu, N Louhelainen, O Michel, P Maestrelli, P Santus, PC Hollman, PF Mercer, PJ Jagielo, R Mahadeva, S Nanua, S Rajendrasozhan, S Shishodia, SK Biswas, SP Davies, SV Culpitt, T Shinohara, T Zheng, U Sajjan, W MacNee, Y Kaneko, Y Nakamaru, Y-T Huang   +63 more
core   +6 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Zinc Chloride Smoke Inhalation Induced Severe Acute Respiratory Distress Syndrome: First Survival in the United States with Extended Duration (Five Weeks) Therapy with High Dose Corticosteroids in Combination with Lung Protective Ventilation

Case Reports in Critical Care, 2017
Zinc chloride smoke bomb exposure is frequently seen in military drills, combat exercises, metal industry works, and disaster simulations. Smoke exposure presents with variety of pulmonary damage based on the intensity of the exposure.
Hafiz Mahboob, Robert Richeson III, Robert McCain   +2 more
doaj   +1 more source

Does a Nebulized Heparin/N-acetylcysteine Protocol Improve Outcomes in Adult Smoke Inhalation?

Plastic and Reconstructive Surgery, Global Open, 2014
Background: Smoke inhalation is a major source of morbidity and mortality. Heparin and N-acetylcysteine treatment has potential efficacy in inhalation injury.
Natalie S. Kashefi, MS, Jonathan I. Nathan, MD, MBA, Sharmila Dissanaike, MD, FACS   +2 more
doaj   +1 more source

Cell death mechanism in an isolated wood smoke inhalation induced-ARDS large animal model [PDF]

, 2021
Acute respiratory distress syndrome (ARDS) is a lethal disease condition in critically ill patients with a reported mortality rate reaching 45%. The current treatment modalities available for severe ARDS are invasive and carry significant risk for ...
Buesing, Keely L., MD, Leiphrakpam, Premila D., PhD, Muendesi, Panashe T., Weber, Hannah R., MFS   +3 more
core   +1 more source