Results 21 to 30 of about 945,943 (347)

Neurogenic Inflammation of Guinea-Pig Bladder

open access: yesMediators of Inflammation, 1994
Capsaicin, substance P, and ovalbumin, instilled into the bladders of naive and ovalbumin (OVA) sensitized guineapigs caused inflammation, as indicated by increased vascular permeability.
D. E. Bjorling, M. R. Saban, R. Saban
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Proteinases as Hormone-Like Signal Messengers: PARs and More

open access: yesJournal of Pharmacological Sciences, 2005
Proteinases like thrombin and trypsin, long known for their ability to activate the coagulation cascade or to act as digestive enzymes for many protein targets, are now recognized as hormone-like regulators of cell function.
Morley D. Hollenberg
doaj   +1 more source

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. [PDF]

open access: yes, 2019
Congenital pulmonary airway malformation (CPAM) is the most common congenital lesion detected in the neonatal lung, which may lead to respiratory distress, infection, and pneumothorax.
Jiang, Yi   +9 more
core   +3 more sources

Biochemical Properties of a Bushmaster Snake Venom Serine Proteinase (LV-Ka), and Its Kinin Releasing Activity Evaluated in Rat Mesenteric Arterial Rings

open access: yesJournal of Pharmacological Sciences, 2004
A serine proteinase with kallikrein-like activity (LV-Ka) has been purified to homogeneity from bushmaster snake (Lachesis muta muta) venom. Physicochemical studies indicated that LV-Ka is a single chain glycoprotein with a molecular mass (Mr) of 33 kDa ...
Maria L.D. Weinberg   +6 more
doaj   +1 more source

Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]

open access: yesPLoS ONE, 2012
Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang   +3 more
doaj   +1 more source

Close relation of arterial ICC-like cells to the contractile phenotype of vascular smooth muscle cell [PDF]

open access: yes, 2007
This work aimed to establish the lineage of cells similar to the interstitial cells of Cajal (ICC), the arterial ICC-like (AIL) cells, which have recently been described in resistance arteries, and to study their location in the artery wall.
Bolton, TB   +5 more
core   +3 more sources

Calcium Handling in Airway Smooth Muscle: Mechanisms and Therapeutic Implications

open access: yesCanadian Respiratory Journal, 1998
Calcium plays a central role in the activation of many cellular processes, including the most relevant end-point in airway smooth muscle physiology: contraction.
Luke J Janssen
doaj   +1 more source

Augmentation of α1-Adrenoceptor-Mediated Contraction by Warming Without Increased Phosphorylation of Myosin in Rat Caudal Arterial Smooth Muscle

open access: yesJournal of Pharmacological Sciences, 2005
We previously reported the relationship between α1-adrenoceptor-mediated contraction and phosphorylation of 20-kDa myosin light chain (LC20) in de-endothelialized rat caudal arterial smooth muscle at room temperature (Mita M, Walsh MP. Biochem J.
Mitsuo Mita   +2 more
doaj   +1 more source

Opiate Modulation of Gastrointestinal Motility and the Actions of Trimebutine

open access: yesCanadian Journal of Gastroenterology, 1991
Trimebutine is an opiate ligand that interacts with the μ, σ and κ receptor subclasses with approximately equal affinity. Since opiate receptors are widely distributed in the gut, and because opiate receptor subtypes may be involved in excitatory or ...
Stephen M Collins, Edwin E Daniel
doaj   +1 more source

Vascular smooth muscle Sirtuin-1 protects against aortic dissection during Angiotensin II-induced hypertension [PDF]

open access: yes, 2015
BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not ...
Akiki, Rachid   +10 more
core   +1 more source

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