Results 71 to 80 of about 2,833,163 (320)
Feedback patterns in simulating intestinal wall motions: interdisciplinary approach to the motility mechanisms [PDF]
arXiv, 2021 Ability of smooth muscles to contract in response to distension plays a crucial role in motor function of intestine. Qualitative analysis of dynamical models using myogenic active property of smooth muscles has shown well agreement with physiologic data.
arxiv
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Journal of Pharmacological Sciences, 2005 Proteinases like thrombin and trypsin, long known for their ability to activate the coagulation cascade or to act as digestive enzymes for many protein targets, are now recognized as hormone-like regulators of cell function.
Morley D. Hollenberg
doaj
Slow Limb Movements Require Precise Control of Muscle Stiffness [PDF]
arXiv, 2015 Slow and accurate finger and limb movements are essential to daily activities, but their neural control and governing mechanics are relatively unexplored. We consider neuromechanical systems where slow movements are produced by neural commands that modulate muscle stiffness.
arxiv
Pattern Formation in a Spatially-Extended Model of Pacemaker Dynamics in Smooth Muscle Cells [PDF]
arXiv, 2021 Spatiotemporal patterns are common in biological systems. For electrically-coupled cells previous studies of pattern formation have mainly used external forcing as the main bifurcation parameter. The purpose of this paper is to show that spatiotemporal patterns in electrically-coupled smooth muscle cells occur even in the absence of forcing.
arxiv
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Journal of Pharmacological Sciences, 2004 A serine proteinase with kallikrein-like activity (LV-Ka) has been purified to homogeneity from bushmaster snake (Lachesis muta muta) venom. Physicochemical studies indicated that LV-Ka is a single chain glycoprotein with a molecular mass (Mr) of 33 kDa ...
Maria L.D. Weinberg +6 more
doaj
Measurements and System Identification for the Characterization of Smooth Muscle Cell Dynamics [PDF]
2024 IEEE International Symposium on Medical Measurements and
Applications (MeMeA)Biological tissue integrity is actively maintained by cells. It is essential to comprehend how cells accomplish this in order to stage tissue diseases. However, addressing the complexity of a cell's system of interrelated mechanisms poses a challenge.
arxiv +1 more source
Interstitial cells: regulators of smooth muscle function.
Physiological Reviews, 2014 Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells. Interstitial cells of mesenchymal origin interact with and form electrical connectivity with smooth muscle cells in many organs, and these cells provide ...
K. Sanders, S. Ward, S. D. Koh
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source