Results 71 to 80 of about 920,258 (356)

Vanadate and smooth muscles.

Japanese Journal of Smooth Muscle Research, 1988
Vanadate is a trace element in biological tissues which has inhibitory actions on various enzymes. It inhibits Na, K-ATPase of smooth muscle membrane. Ca-ATPase and Ca-uptake of membranous systems of smooth muscle cells are also inhibited by vanadate. Vanadate induces contractions in various smooth muscles.
openaire   +4 more sources

Electrophysiology of Syncytial Smooth Muscle [PDF]

Journal of Experimental Neuroscience, 2019
As in other excitable tissues, two classes of electrical signals are of fundamental importance to the functioning of smooth muscles: junction potentials, which arise from neurotransmission and represent the initiation of excitation (or in some instances inhibition) of the tissue, and spikes or action potentials, which represent the accomplishment of ...
Rohit Manchanda, Shailesh Appukuttan, Mithun Padmakumar   +2 more
openaire   +4 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

The Atypical Cadherin FAT1 Limits Mitochondrial Respiration and Proliferation of Vascular Smooth Muscle Cells

Frontiers in Cardiovascular Medicine, 2022
Smooth muscle cells contribute to cardiovascular disease, the leading cause of death worldwide. The capacity of these cells to undergo phenotypic switching in mature arteries of the systemic circulation underlies their pathogenic role in atherosclerosis ...
Dario F. Riascos-Bernal, Dario F. Riascos-Bernal, Alishba Maira, Nicholas E. S. Sibinga, Nicholas E. S. Sibinga   +4 more
doaj   +1 more source

Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury [PDF]

, 2014
Background The origins of neointimal smooth muscle cells that arise following vascular injury remains controversial. Studies have suggested that these cells may arise from previously differentiated medial vascular smooth muscle cells, resident stem ...
Burlak, Christopher, Herring, Brian Paul, Hoggatt, April M., Offermanns, Stefan   +3 more
core   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Smooth muscle cells largely develop independently of functional hemogenic endothelium

Stem Cell Research, 2014
Vascular smooth muscle cells represent a major component of the cardiovascular system. In vitro studies have shown that FLK1+ cells derived from embryonic stem (ES) cells can differentiate into both endothelial and smooth muscle cells.
Monika Stefanska, Guilherme Costa, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud   +4 more
doaj   +1 more source

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]

PLoS ONE, 2015
Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz, Tamara C Murphy, Anastassia P Pokutta-Paskaleva, Rudolph L Gleason, Alicia N Lyle, W Robert Taylor, Mitsi A Blount, Juan Cheng, Qinglin Yang, Roy L Sutliff, C Michael Hart   +10 more
doaj   +1 more source

MMP-1 activation contributes to airway smooth muscle growth and asthma severity [PDF]

, 2016
Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity.
Berger P, Catherine Reynolds, Charlotte K. Billington, Christopher Philp, David J. Jackson, Debbie Clements, Dominick E. Shaw, Hasaneen NA, Irshad Soomro, Johnson S, Karlinsky JB, Naveed S, Rajah R, Sebastian L. Johnston, Shams-un-nisa Naveed, Simon R. Johnson, Timothy W. Harrison   +16 more
core   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source