Results 21 to 30 of about 353,240 (263)

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

Pulmonary Circulation, 2020
Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu, Haiyang Tang, Ruizhu Lin, Shane G. Carr, Ziyi Wang, Aleksandra Babicheva, Ramon J. Ayon, Pritesh P. Jain, Mingmei Xiong, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Shayan Rahimi, Daniela Valdez-Jasso, Tatum S. Simonson, Ankit A. Desai, Joe G.N. Garcia, John Y.-J. Shyy, Patricia A. Thistlethwaite, Jian Wang, Ayako Makino, Jason X.-J. Yuan   +21 more
doaj   +1 more source

Cyclic Mechanical Stretch Induced Smooth Muscle Cell Changes in Cerebral Aneurysm Progress by Reducing Collagen Type IV and Collagen Type VI Levels

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cerebral aneurysm growth is characterized by continuous structural weakness of local smooth muscle cells, though the mechanism is unclear.
Peixi Liu, Yaying Song, Yingjie Zhou, Yingjun Liu, Tianming Qiu, Qingzhu An, Jianping Song, Peiliang Li, Yuan Shi, Sichen Li, Kai Quan, Guo-Yuan Yang, Wei Zhu   +12 more
doaj   +1 more source

A heparin–rosuvastatin-loaded P(LLA-CL) nanofiber-covered stent inhibits inflammatory smooth-muscle cell viability to reduce in-stent stenosis and thrombosis

Journal of Nanobiotechnology, 2021
Background An endovascular covered-stent has unique advantages in treating complex intracranial aneurysms; however, in-stent stenosis and late thrombosis have become the main factors affecting the efficacy of covered-stent treatment.
Yingjun Liu, Peixi Liu, Yaying Song, Sichen Li, Yuan Shi, Kai Quan, Guo Yu, Peiliang Li, Qingzhu An, Wei Zhu   +9 more
doaj   +1 more source

Connexin 43 is Localized in Gizzard Smooth Muscle Cells during Chicken Development

The Journal of Poultry Science, 2022
Smooth muscle cells are widely distributed in the digestive organs of chickens. They exist as single cells, but adhere to each other to function synchronously.
Kosuke Tokunaga, Shota Akimoto, Machiko Aiba, Mutsuki Nakagomi, Takahiro Suzuki, Ryuichi Tatsumi, Mako Nakamura   +6 more
doaj   +1 more source

Caveolin-3 promotes a vascular smooth muscle contractile phenotype

Frontiers in Cardiovascular Medicine, 2015
Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle cells are believed to play an essential role in the development of ...
Jorge L. Gutierrez-Pajares, Jeannette eIturrieta, Vipin eDulam, Yu eWang, Yu eWang, Stephanos ePavlides, Gabriella eMalacari, Michael P. Lisanti, Philippe G. Frank   +8 more
doaj   +1 more source

Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro

Frontiers in Physiology, 2022
Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic, Fatima Daoud, Fatima Daoud, Neserin Ali, Katarzyna Kawka, Johan Holmberg, Sebastian Albinsson   +6 more
doaj   +1 more source

Regulation of human airway smooth muscle cell migration and relevance to asthma

Respiratory Research, 2017
Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass.
Brittany Salter, Cara Pray, Katherine Radford, James G. Martin, Parameswaran Nair   +4 more
doaj   +1 more source

Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins

Journal of Extracellular Vesicles, 2020
The vascular endothelium and smooth muscle form adjacent cellular layers that comprise part of the vascular wall. Each cell type can regulate the other’s structure and function through a variety of paracrine effectors.
Michael J. Boyer, Yayoi Kimura, Tomoko Akiyama, Ariele Y. Baggett, Kyle J. Preston, Rosario Scalia, Satoru Eguchi, Victor Rizzo   +7 more
doaj   +1 more source

TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms

JACC: Basic to Translational Science, 2023
Summary: Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer ...
Jing Wang, MM, Xiaoxiang Tian, MD, Chenghui Yan, MD, Hanlin Wu, MM, Yuxin Bu, MM, Jia Li, MD, Dan Liu, MD, Yaling Han, MD, PhD   +7 more
doaj   +1 more source

Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk. [PDF]

Nat Commun
Vascular smooth muscle cells contribute to heritable coronary artery disease risk and undergo complex transitions to multiple disease-related phenotypes.
Li DY, Kundu S, Cheng P, Gu W, Worssam MD, Jackson WR, Zhao Q, Nguyen T, Yu AM, Monteiro JP, Caceres RD, Dale S, Palmisano BT, Weldy CS, Ramste M, Kundu R, Kundaje A, Wirka RC, Quertermous T.   +18 more
europepmc   +2 more sources