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Journal of Cell Biology, 1971 Smooth muscle derived from the inner media and intima of immature guinea pig aorta were grown for up to 8 wk in cell culture. The cells maintained the morphology of smooth muscle at all phases of their growth in culture. After growing to confluency, they
R. Ross
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Smooth Muscle Cell Reprogramming in Aortic Aneurysms
Cell Stem Cell, 2020 Summary The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal TGFβ signaling in smooth muscle.
Guangxin Li, Zhen Zhuang, Pei-Yu Chen
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Regulation of human airway smooth muscle cell migration and relevance to asthma
Respiratory Research, 2017 Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass.
Brittany Salter +4 more
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Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis
Multidisciplinary Respiratory Medicine, 2013 Background Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be due to an up-
Khan Mohammad Afzal
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Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis
Circulation, 2021 Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single cell RNA-sequencing, and human genomics have been integrated to gain ...
Joseph Miano +2 more
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Autophagic regulation of smooth muscle cell biology
Redox Biology, 2015 Autophagy regulates the metabolism, survival, and function of numerous cell types, including those comprising the cardiovascular system. In the vasculature, changes in autophagy have been documented in atherosclerotic and restenotic lesions and in ...
Joshua K. Salabei, Bradford G. Hill
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Vascular smooth muscle cells in atherosclerosis [PDF]
Nature Reviews Cardiology, 2019 Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and ...
Gemma Basatemur +4 more
semanticscholar +4 more sources
Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk [PDF]
Nature CommunicationsVascular smooth muscle cells contribute to heritable coronary artery disease risk and undergo complex transitions to multiple disease-related phenotypes.
Daniel Y. Li +18 more
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How vascular smooth muscle cell phenotype switching contributes to vascular disease
Cell Communication and Signaling, 2022 Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a ...
Genmao Cao +5 more
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Frontiers in Cardiovascular Medicine, 2022 Smooth muscle cells contribute to cardiovascular disease, the leading cause of death worldwide. The capacity of these cells to undergo phenotypic switching in mature arteries of the systemic circulation underlies their pathogenic role in atherosclerosis ...
Dario F. Riascos-Bernal +4 more
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