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Journal of Cell Biology, 1971 Smooth muscle derived from the inner media and intima of immature guinea pig aorta were grown for up to 8 wk in cell culture. The cells maintained the morphology of smooth muscle at all phases of their growth in culture. After growing to confluency, they grew in multiple overlapping layers.
Russell Ross, Ross Russell
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Defining smooth muscle cells and smooth muscle injury [PDF]
Journal of Clinical Investigation, 2005 For 3 decades, terms such as synthetic phenotype and contractile phenotype have been used to imply the existence of a specific mechanism for smooth muscle cell (SMC) responses to injury. In this issue of the JCI, Hendrix et al. offer a far more precise approach to examining the mechanisms of SMC responses to injury, focused not on general changes in ...
William M, Mahoney, Stephen M, Schwartz
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EPAC in Vascular Smooth Muscle Cells [PDF]
International Journal of Molecular Sciences, 2020 Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Nadine Wehbe +9 more
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Circulation Research, 2000 Severe clinical manifestations of atherosclerosis, including sudden death, myocardial infarction, and stroke, mainly result from atherosclerotic plaque rupture/erosion that triggers thrombus formation, leading to occlusion of the vessel lumen.1 The occluding thrombus is mixed in nature and contains significant quantities of fibrin in addition to ...
Alain Tedgui, Ziad Mallat
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Smooth muscle stem cells [PDF]
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2003 AbstractVascular smooth muscle cells (SMCs) originate from multiple types of progenitor cells. In the embryo, the most well studied SMC progenitor is the cardiac neural crest stem cell. Smooth muscle differentiation in the neural crest lineage is controlled by a combination of cell intrinsic factors, including Pax3, Tbx1, FoxC1, and serum response ...
Karen K, Hirschi, Mark W, Majesky
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Smoothelin in Vascular Smooth Muscle Cells [PDF]
Trends in Cardiovascular Medicine, 2007 Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for ...
van Eys, G.J.J.M. +2 more
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Retinoids and Arterial Smooth Muscle Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2000 Retinoic acid (RA), the active metabolite of vitamin A, is a crucial signaling molecule during vertebrate development and plays key roles in establishing cell lineages as well as in cell differentiation and proliferation.1 RA has been shown to influence the expression of many genes ( see the Table⇓ ) through interactions between RA receptors (RARs) and
Neuville, P. +2 more
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Vascular Smooth Muscle Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016 Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully differentiated phenotype conferred by the transcriptional activity of myocardin and serum response ...
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Smooth Muscle Cell Plasticity [PDF]
Circulation Research, 2013 More than 50 years ago, smooth muscle cells (SMC) of the carotid artery were shown to undergo "de-differentiation" upon ligation injury. 1 Since this classic study, scores of research groups have used a variety of in vivo and in vitro model systems as well as numerous clinical studies to demonstrate the conversion of normally contractile vascular SMC
Nguyen, Anh T. +17 more
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Circulation Research, 2006 See related article, pages 472–479 The concept that the atheromatous plaque undergoes a complex inflammatory and fibroproliferative process, which is likely responsible for the onset of complications,1 and the notion of vulnerable plaque2 have acquired wide acceptance during the last years.
Bochaton-Piallat, Marie-Luce +1 more
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