Role of smooth muscle progenitor cells in vascular mechanical injury and repair
Medicine in Novel Technology and Devices, 2022 Smooth muscle progenitor cells are precursor cells that express both smooth muscle cell and stem cell markers, and can differentiate into smooth muscle cells under specific condition.
Zhu-feng Dong +7 more
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Frontiers in Cardiovascular Medicine, 2022 Smooth muscle cells contribute to cardiovascular disease, the leading cause of death worldwide. The capacity of these cells to undergo phenotypic switching in mature arteries of the systemic circulation underlies their pathogenic role in atherosclerosis ...
Dario F. Riascos-Bernal +4 more
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Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism. [PDF]
PLoS ONE, 2014 Smooth muscle cells are maintained in a differentiated state in the vessel wall, but can be modulated to a synthetic phenotype following injury. Smooth muscle phenotypic modulation is thought to play an important role in the pathology of vascular ...
Feng Shi +4 more
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Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]
PLoS ONE, 2015 Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz +10 more
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Senescence as a Driver of Smooth Muscle Cell Plasticity and Atherosclerosis: Mechanisms and Therapeutic Opportunities. [PDF]
CellsCell senescence is increasingly recognized as a key driver of atherosclerosis progression. Senescent smooth muscle cells (SMCs) lose their proliferative capacity and adopt a pro-inflammatory profile, contributing to impaired vessel repair and weakening ...
Steegen L, Grootaert MOJ.
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Pathologic bladder microenvironment attenuates smooth muscle differentiation of skin derived precursor cells: implications for tissue regeneration. [PDF]
PLoS ONE, 2013 Smooth muscle cell containing organs (bladder, heart, blood vessels) are damaged by a variety of pathological conditions necessitating surgery or organ replacement.
Cornelia Tolg +6 more
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Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis
Multidisciplinary Respiratory Medicine, 2013 Background Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be due to an up-
Khan Mohammad Afzal
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Journal of Biomechanical Science and Engineering, 2006 This study investigated nitric oxide (NO) production and phenotype changes of smooth muscle cells (SMC) in a cocultured model (CM) exposed to fluid shear stress. The CM was composed of human umbilical endothelial cells (EC) and SMC, a collagen layer, and
Naoya SAKAMOTO +3 more
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Smooth muscle cells largely develop independently of functional hemogenic endothelium
Stem Cell Research, 2014 Vascular smooth muscle cells represent a major component of the cardiovascular system. In vitro studies have shown that FLK1+ cells derived from embryonic stem (ES) cells can differentiate into both endothelial and smooth muscle cells.
Monika Stefanska +4 more
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Smooth Muscle Cell-Derived Fibronectin Promotes an Atheroprotective Smooth Muscle Cell Phenotype Associated With Altered NO-cGMP Signaling. [PDF]
J Am Heart AssocBackground Coronary artery disease due to atherosclerosis is the leading cause of death worldwide. Recent studies revealed an important role of smooth muscle cell (SMC) phenotypic switching in atherogenesis.
Feil S +8 more
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