Results 31 to 40 of about 353,240 (263)

Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension

Cell Reports, 2018
Summary: Pulmonary hypertension is a devastating disease characterized by excessive vascular muscularization. We previously demonstrated primed platelet-derived growth factor receptor β+ (PDGFR-β+)/smooth muscle cell (SMC) marker+ progenitors at the ...
Abdul Q. Sheikh, Fatima Zahra Saddouk, Aglaia Ntokou, Renata Mazurek, Daniel M. Greif   +4 more
doaj   +1 more source

Vascular smooth muscle cell dysfunction in neurodegeneration

Frontiers in Neuroscience, 2022
Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is ...
Genevieve Hayes, Joana Pinto, Sierra N. Sparks, Congxiyu Wang, Congxiyu Wang, Sana Suri, Sana Suri, Daniel P. Bulte   +7 more
doaj   +1 more source

Smooth muscle cells and vascular diseases [PDF]

Cardiovascular Research, 2012
Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, and, due to their myosin/actin interactions, they are also responsible for arterial contractile tonus and regulating blood pressure and flow in relation to specific metabolic demands.
Jean-Baptiste, Michel, Zhenlin, Li, Patrick, Lacolley   +2 more
openaire   +2 more sources

Ureter smooth muscle cell orientation in rat is predominantly longitudinal. [PDF]

PLoS ONE, 2014
In ureter peristalsis, the orientation of the contracting smooth muscle cells is essential, yet current descriptions of orientation and composition of the smooth muscle layer in human as well as in rat ureter are inconsistent.
Bart Spronck, Jort J Merken, Koen D Reesink, Wilco Kroon, Tammo Delhaas   +4 more
doaj   +1 more source

Single-cell sequencing reveals PHLDA1-positive smooth muscle cells promote local invasion in head and neck squamous cell carcinoma

Translational Oncology
Background: Smooth muscle cells within the tumor microenvironment play a crucial role in cancer progression. However, their involvement in the local invasion of head and neck squamous cell carcinoma remains poorly understood.
Bing Guo, Xutao Wen, Shun Yu, Jun Yang
doaj   +1 more source

Smooth Muscle Cells: To Be or Not To Be? [PDF]

Circulation Research, 2013
The conversion of contractile vascular smooth muscle cells (SMCs) to a synthetic or proliferative phenotype is thought to play a major role in vascular diseases, such as atherosclerosis and restenosis.1–3 Our recent work presents evidence that challenges this widely accepted dogma. Our findings suggest that multipotent vascular stem cells (MVSCs) are a
Zhenyu, Tang, Aijun, Wang, Dong, Wang, Song, Li   +3 more
openaire   +2 more sources

Caveolar nanospaces in smooth muscle cells [PDF]

Journal of Cellular and Molecular Medicine, 2006
Caveolae, specialized membrane nanodomains, have a key role in signaling processes, including calcium handling in smooth muscle cells (SMC). We explored the three-dimensional (3D) architecture of peripheral cytoplasmic space at the nanoscale level and the close spatial relationships between caveolae, sarcoplasmic reticulum (SR), and mitochondria, as ...
Gherghiceanu, Mihaela, Popescu, L M
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions

Scientific Reports
Anoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear.
Neha Gupta, Salah A. Baker, Kenton M. Sanders, Kaneez E. Rabab, Denzel KF. Thean, Tuleen Alkawadri, Caoimhin S. Griffin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Bernard T. Drumm   +10 more
doaj   +1 more source

Outgrowing endothelial and smooth muscle cells for tissue engineering approaches

Journal of Tissue Engineering, 2017
In recent years, circulating progenitors of endothelial cells and smooth muscle cells were identified in the peripheral blood. In our study, we evaluated the utilization of both cell types isolated and differentiated from peripheral porcine blood in ...
Moritz Kolster, Mathias Wilhelmi, Claudia Schrimpf, Andres Hilfiker, Axel Haverich, Thomas Aper   +5 more
doaj   +1 more source