Results 131 to 140 of about 2,656,785 (305)

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

eLife, 2013
The dynamic organization of signaling cascades inside primary cilia is key to signal propagation. Yet little is known about the dynamics of ciliary membrane proteins besides a possible role for motor-driven Intraflagellar Transport (IFT). To characterize
Fan Ye, David K Breslow, Elena F Koslover, Andrew J Spakowitz, W James Nelson, Maxence V Nachury   +5 more
doaj   +1 more source

eXamine: a Cytoscape app for exploring annotated modules in networks [PDF]

, 2013
Background. Biological networks have growing importance for the interpretation of high-throughput "omics" data. Statistical and combinatorial methods allow to obtain mechanistic insights through the extraction of smaller subnetwork modules.
Bucur, Cristina-Iulia, Dinkla, Kasper, El-Kebir, Mohammed, Klau, Gunnar W., Siderius, Marco, Smit, Martine J., Westenberg, Michel A.   +6 more
core   +2 more sources

Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]

, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan, Alewijnse AE, Ariens EJ, Brown EM, Cesarman E, Chen F, Clark AJ, Clark AJ, Cobbs CS, Furchgott RF, Furchgott RF, Garcia-Borron JC, Henk Timmerman, Henry F. Vischer, Leonardo Pardo, Mannstadt M, Martine J. Smit, Murphy PM, Nauta WT, Rauser L, Reiter EO, Remko A. Bakker, Rob Leurs, Rossier O, Samama P, Scheer A, Stephenson RP, Tabs S, Weiner DM, Wieland K   +29 more
core   +3 more sources

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

The Genetic Signature of Perineuronal Oligodendrocytes [PDF]

, 2008
Oligodendrocytes in the central nervous system can be categorized as precursors, myelin-forming, and non-myelinating perineuronal cells. The function of perineuronal oligodendrocytes is unknown; it was proposed that following injury, they may remyelinate
Dragan Maric, Gabor Lovas, Javier Martinez de Velasco, Joseph A. Nielsen, Lynn D. Hudson, Sara Szuchet   +5 more
core   +1 more source

Investigation of Laser Ablation and Brush Pre‐Treatments for AlCu Cold Roll Bonding in Oxygen‐Free Conditions

Advanced Engineering Materials, EarlyView.
It is shown that laser ablation pretreatment under oxygen‐free conditions enables copper–aluminium bonding at significantly lower deformation degrees and improved properties compared to mechanical brushing. Laser ablation further increases interface contact area and induces favourable residual stress states and microstructural compatibility ...
Khemais Barienti, Finn‐Lennard Janthur, Selina Raumel, Sascha Jan Zimmermann, Sarah Seffer, René Gustus, Sebastian Herbst, Marc C. Wurz, Ludger Overmeyer, Wolfgang Maus‐Friedrichs, Hans Jürgen Maier, Florian Nürnberger   +11 more
wiley   +1 more source

Tribological Performance of 60NiTi Alloy Under Varying Contact Conditions and Elevated Temperatures in Linear Reciprocating Sliding

Advanced Engineering Materials, EarlyView.
This study investigates the tribological response of 60NiTi alloy under dry, water‐lubricated and high‐temperature conditions. The alloy exhibits decreasing wear volume and friction with increasing temperature due to the formation of protective oxide layers. The work clarifies dominant wear mechanisms and demonstrates the suitability of 60NiTi for high‐
Anthony Onyebuchi Okoani, Miguel Angel Selles, Maziar Ramezani   +2 more
wiley   +1 more source

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. [PDF]

PLoS Biology
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and physically ...
Madison F Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Annabel Lee, Alyssa B Long, Mattie J Casey, Abhishek Poddar, Isaac B Nelson, Corvin D Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M Kwan, Stefan Schulz, Rodney A Stewart, John J G Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R Myers   +23 more
doaj   +1 more source

A Computational Algebra Approach to the Reverse Engineering of Gene Regulatory Networks

, 2003
This paper proposes a new method to reverse engineer gene regulatory networks from experimental data. The modeling framework used is time-discrete deterministic dynamical systems, with a finite set of states for each of the variables.
Abbott, Albert, Berman, Bower, Brandilyn Stigler, Cadigan, Cho, Cox, de Jong, de la Fuente, Filkov, Filkov, Friedman, Gardner, Ingham, Ingham, Kauffman, Kitano, Lang, Lewis, Mendes, Mendes, Mendoza, Muraille, Pe'er, Reinhard Laubenbacher, Repsilber, Robbiano, Schmulevich, Soinov, Spellman, Thieffry, Thomas, Yeung   +33 more
core   +2 more sources

Tailored Hierarchical Porous Copper Architectures via Three Dimensional Printing and Pressure‐less Sintering for Next‐Generation Lithium‐Metal Batteries

Advanced Engineering Materials, EarlyView.
A hierarchical porous copper current collector is fabricated via three‐dimensional printing combined with pressureless sintering to stabilize lithium metal anodes. The interconnected architecture lowers local current density, guides uniform Li deposition within pores, and suppresses dendrite growth.
Alok Kumar Mishra, Mukul Shukla
wiley   +1 more source