Results 61 to 70 of about 87,742 (317)

Of Snakes, Snails, and Surrogates [PDF]

Neuron, 2001
The high-resolution structure of a synthetic 13-residue peptide in a tight complex with alpha-bungarotoxin conforms to the beta hairpin structure of a closely related segment in the ACh binding protein and reveals how the ACh binding protein and the homologous nicotinic ACh receptors bind alpha-bungarotoxin at their ACh binding sites.
openaire   +3 more sources

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Comparative diagnostic imaging in giant African land snails (Achatinidae)

Frontiers in Veterinary Science, 2023
Giant African land snails (GALS) have become increasingly popular, for example, as pets or in kindergartens in Europe, but little is known about their clinically relevant anatomy, diseases, or further details in diagnostic imaging.
Michaela Gumpenberger, Silvana Schmidt-Ukaj, Stephan Handschuh   +2 more
doaj   +1 more source

Dissecting the Phase Space Snail Shell [PDF]

, 2019
The on-going vertical phase mixing, manifesting itself as a snail shell in the $Z-V_{Z}$ phase space, has been discovered with the Gaia DR2 data. To better understand the origin and properties of the phase mixing process, we study the vertical phase-mixing signatures in arches (including the classical ``moving groups'') of the $V_{R}-V_{\phi}$ phase ...
arxiv   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Snail against snail

California Agriculture, 1980
The decollate snail feeds on brown garden snail without harming healthy plants or fruit.
T Fisher, R Orth, S Swanson
doaj  

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors

eLife, 2020
Schistosomiasis is a debilitating parasitic disease infecting hundreds of millions of people. Schistosomes use aquatic snails as intermediate hosts.
Jacob A Tennessen, Stephanie R Bollmann, Ekaterina Peremyslova, Brent A Kronmiller, Clint Sergi, Bulut Hamali, Michael Scott Blouin   +6 more
doaj   +1 more source

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source