Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies
Toxicon, 2003 Snake Venom Metalloproteinases (SVMPs) are synthesized as zymogens and undergo proteolytic processing resulting in a variety of multifunctional proteins. Jararhagin is a P-III SVMP, isolated from the venom of Bothrops jararaca, comprising metalloproteinase, disintegrin-like and cysteine-rich domains.
Tanjoni, Isabelle +8 more
openaire +4 more sources
Progress of ADAM17 in Fibrosis‐Related Diseases
Mediators of Inflammation, Volume 2025, Issue 1, 2025.Fibrosis leads to structural damage and functional decline and is characterized by an accumulation of fibrous connective tissue and a reduction in parenchymal cells. Because of its extremely poor prognosis, organ fibrosis poses a significant economic burden.
Suyan Yan +7 more
wiley +1 more source
Venomics and Cellular Toxicity of Thai Pit Vipers (Trimeresurus macrops and T. hageni)
Toxins, 2020 The two venomous pit vipers, Trimeresurus macrops and T. hageni, are distributed throughout Thailand, although their abundance varies among different areas.
Supeecha Kumkate +9 more
doaj +1 more source
A proteomics and transcriptomics investigation of the venom from the Barychelid spider Trittame loki (brush-foot trapdoor) [PDF]
, 2013 Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as
Agostino Antunes +17 more
core +3 more sources
Metabolomics‐driven approaches for identifying therapeutic targets in drug discovery
MedComm, Volume 5, Issue 11, November 2024.Various metabolomics‐based methods were outlined that have been employed for target identification, such as dose–response metabolomics, stable isotope‐resolved metabolomics, mass spectrometry imaging metabolomics. Furthermore, the emerging potentials of target identification based on metabolomics, such as artificial intelligence, single‐cell ...
Shanshan Pan +11 more
wiley +1 more source
Variations in neurotoxicity and proteome profile of Malayan krait (Bungarus candidus) venoms.
PLoS ONE, 2019 Malayan krait (Bungarus candidus) is a medically important snake species found in Southeast Asia. The neurotoxic effects of envenoming present as flaccid paralysis of skeletal muscles.
Muhamad Rusdi Ahmad Rusmili +7 more
doaj +1 more source
The urgent need to develop novel strategies for the diagnosis and treatment of snakebites [PDF]
, 2019 Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills over one hundred thousand people per year. However, many millions of survivors also suffer through disabilities and long-term health consequences.
Aagaard-Hansen +39 more
core +1 more source
VenomCap: An exon‐capture probe set for the targeted sequencing of snake venom genes
Molecular Ecology Resources, Volume 24, Issue 8, November 2024.Abstract Snake venoms are complex mixtures of toxic proteins that hold significant medical, pharmacological and evolutionary interest. To better understand the genetic diversity underlying snake venoms, we developed VenomCap, a novel exon‐capture probe set targeting toxin‐coding genes from a wide range of elapid snakes, with a particular focus on the ...
Scott L. Travers +6 more
wiley +1 more source
The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox).
PLoS Neglected Tropical Diseases, 2020 Snake venoms are complex mixtures of proteins with toxic activities, with many distinct isoforms, affecting different physiological targets, comprised in a few protein families.
Ana Maria Moura-da-Silva +15 more
doaj +1 more source
Toxicon: X, 2020 Snakebite is a socio-economic problem in tropical countries and it is exacerbated by geographical venom variation of snakes. We investigated on venom variation in geographically distinct populations of Echis carinatus from three ecologically distinct ...
Siddharth Bhatia, Karthikeyan Vasudevan
doaj +1 more source