Results 1 to 10 of about 180,611 (146)

Serum miRNAs Expression and SNAP-25 Genotype in Alzheimer’s Disease [PDF]

Frontiers in Aging Neuroscience, 2019
MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression by binding their 3′ untranslated region (3′UTR) region; these molecules play a fundamental role in several pathologies, including Alzheimer’s disease (AD).
Simone Agostini, Roberta Mancuso, Gaia Liuzzo, Elisabetta Bolognesi, Andrea Saul Costa, Anna Bianchi, Mario Clerici, Mario Clerici   +7 more
doaj   +5 more sources

miR-23a-3p and miR-181a-5p modulate SNAP-25 expression. [PDF]

PLoS ONE, 2023
SNAP-25 protein is a key protein of the SNARE complex that is involved in synaptic vesicles fusion with plasma membranes and neurotransmitter release, playing a fundamental role in neural plasticity.
Simone Agostini, Elisabetta Bolognesi, Roberta Mancuso, Ivana Marventano, Lorenzo Agostino Citterio, Franca Rosa Guerini, Mario Clerici   +6 more
doaj   +2 more sources

Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy, 2022
Background Synaptic dysfunction and degeneration are central to Alzheimer’s disease (AD) and have been found to correlate strongly with cognitive decline.
Johanna Nilsson, Nicholas J. Ashton, Andrea L. Benedet, Laia Montoliu-Gaya, Johan Gobom, Tharick A. Pascoal, Mira Chamoun, Erik Portelius, Andreas Jeromin, Muriel Mendes, Henrik Zetterberg, Pedro Rosa-Neto, Ann Brinkmalm, Kaj Blennow   +13 more
doaj   +2 more sources

The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses [PDF]

iScience, 2022
Summary: Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of the canonical neuronal SNARE complex in this exocytotic process has so far remained ...
Charlotte Calvet, Thibault Peineau, Najate Benamer, Maxence Cornille, Andrea Lelli, Baptiste Plion, Ghizlène Lahlou, Julia Fanchette, Sylvie Nouaille, Jacques Boutet de Monvel, Amrit Estivalet, Philippe Jean, Vincent Michel, Martin Sachse, Nicolas Michalski, Paul Avan, Christine Petit, Didier Dulon, Saaid Safieddine   +18 more
doaj   +2 more sources

Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment. [PDF]

PLoS Pathogens
Botulinum Neurotoxin Serotype A (BoNT/A), responsible for most human botulism cases, inhibits neurotransmitter release by cleaving the target protein SNAP-25. Previous literature demonstrated that BoNT/A mediated cleavage of a small subset of the SNAP-25
Dilara Koc, Sena Ezgin, Ebru Kavakli, Krishna P Kota, Edanur Sen, Christopher Mahone, Mary Ellen Palko, Lisa H Cazares, Tolga Can, Lino Tessarollo, Sina Bavari, Antoine Marion, Erkan Kiris   +12 more
doaj   +2 more sources

Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope [PDF]

Antibodies, 2022
Botulinum neurotoxin type E (BoNT/E), the fastest acting toxin of all BoNTs, cleaves the 25 kDa synaptosomal-associated protein (SNAP-25) in motor neurons, leading to flaccid paralysis. The specific detection and quantification of the BoNT/E-cleaved SNAP-
Adva Mechaly, Eran Diamant, Ron Alcalay, Alon Ben David, Eyal Dor, Amram Torgeman, Ada Barnea, Meni Girshengorn, Lilach Levin, Eyal Epstein, Ariel Tennenhouse, Sarel J. Fleishman, Ran Zichel, Ohad Mazor   +13 more
doaj   +2 more sources

Diagnostic and prognostic value of cerebrospinal fluid SNAP-25 and neurogranin in Creutzfeldt-Jakob disease in a clinical setting cohort of rapidly progressive dementias [PDF]

Alzheimer’s Research & Therapy, 2023
Background The levels of synaptic markers synaptosomal-associated protein 25 (SNAP-25) and neurogranin (Ng) have been shown to increase early in the cerebrospinal fluid (CSF) of patients with Creutzfeldt-Jakob disease (CJD) and to have prognostic ...
Giuseppe Mario Bentivenga, Simone Baiardi, Andrea Mastrangelo, Corrado Zenesini, Angela Mammana, Barbara Polischi, Sabina Capellari, Piero Parchi   +7 more
doaj   +2 more sources

Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia [PDF]

BMJ Mental Health
Background Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD).Objective To investigate the diagnostic utility of the soluble N ...
Patrick Oeckl, Petra Steinacker, Markus Otto, Steffen Halbgebauer, MHD Rami Al Shweiki, Samir Abu-Rumeileh, Naguib Mechawar, Carlos Schönfeldt-Lecuona, Lorenzo Barba, Leonie Werner, Alexander Tarabuko, Ilyas Al-Ali, Christopher R Pryce, Nadia Cattane, Giulia Poggi, Heiko Graf, Henning Großkopf, Laura Meier, Hugh Marston, Klaus D Bornemann, Bastian Hengerer, Karin M Danzer   +21 more
doaj   +2 more sources

SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice [PDF]

Communications Biology
SNARE-mediated vesicular transport is thought to play roles in photoreceptor glutamate exocytosis and photopigment delivery. However, the functions of Synaptosomal-associated protein (SNAP) isoforms in photoreceptors are unknown.
Mengjia Huang, Chun Hin Chow, Akshay Gurdita, Hidekiyo Harada, Victor Q. B. Pham Truong, Sarah Eide, Hong-Shuo Sun, Zhong-Ping Feng, Philippe P. Monnier, Valerie A. Wallace, Shuzo Sugita   +10 more
doaj   +2 more sources

Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder [PDF]

Frontiers in Human Neuroscience, 2023
ObjectivesAttention-deficit/hyperactivity disorder (ADHD) is one of the most widespread and highly heritable neurodevelopmental disorders affecting children worldwide.
Wenxian Huang, Wenxian Huang, Ahmed Ameen Fateh, Yilin Zhao, Yilin Zhao, Hongwu Zeng, Binrang Yang, Diangang Fang, Linlin Zhang, Xianlei Meng, Muhammad Hassan, Feiqiu Wen   +11 more
doaj   +2 more sources