Results 131 to 140 of about 150,506 (397)

Alternate routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4 [PDF]

, 2015
Insulin-stimulated delivery of glucose transporters (GLUT4) from specialized intracellular GLUT4 storage vesicles (GSVs) to the surface of fat and muscle cells is central to whole-body glucose.
Bryant, Nia J., Gould, Gwyn W., Kioumourtzoglou, Dimitrios, Pryor, Paul R.   +3 more
core   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Effectiveness and safety of cold versus hot snare polypectomy: A meta‐analysis

Journal of Gastroenterology and Hepatology, 2018
Removal of neoplastic polyps is important for colorectal cancer prevention. The primary aim was to compare the complete resection rate of diminutive (≤ 5 mm) or small colorectal polyps (6–10 mm) using cold snare polypectomy (CSP) versus hot snare ...
Junyan Qu, H. Jian, Lixiang Li, Yan Zhang, Bing-cheng Feng, Zhen Li, Xiu-li Zuo   +6 more
semanticscholar   +1 more source

Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1 [PDF]

, 2017
Background: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane.
Baker, K, Clayton-Smith, J, Dabir, T, DDD Study, Evers, JMG, Josifova, D, Joss, S, Kerr, B, Kraus, A, Laskowski, RA, McEntagart, M, Morton, J, O'Brien, S, Smith, A, Splitt, M, Suri, M, Thornton, JM, Wright, CF   +17 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Efficacy and safety of cold snare resection in preventive screening colonoscopy

Endoscopy International Open, 2017
Background and aim Removal of polyps during colonoscopy effectively prevents the development of colorectal cancer. So far, snare resection with high frequency current with or without prior submucosal saline injection is the method of choice.
B. Schett, J. Wallner, V. Weingart, A. Ayvaz, U. Richter, J. Stahl, H.-D. Allescher   +6 more
doaj   +1 more source

"Set phasors to stun": an algorithm to improve phase coherence on transients in multi-microphone recordings [PDF]

, 2007
Ever since the advent of multi-microphone recording, sound engineers have wrestled with the colouration of sound by phasing issues. For some this was an anathema; for others this colouration was a crucial ingredient of the finished product. Traditionally,
Paterson, Justin
core  

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Molecular mechanism of fusion pore formation driven by the neuronal SNARE complex

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance SNARE proteins facilitate the synaptic vesicle fusion with the plasma membrane. The structure of the fusion pore and the mechanism of its formation are not clearly understood. Using coarse-grained molecular dynamics simulations of a nanodisc
Satyan Sharma, M. Lindau
semanticscholar   +1 more source

An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]

, 2003
The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B., Knopf, Lea G., Li, Yajie, Marti, Matthias, Müller, Norbert, Regös, Attila, Schraner, Elisabeth M., Wild, Peter   +7 more
core   +1 more source