Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes [PDF]
eLife, 2020 The Ca2+ sensor synaptotagmin-1 and the SNARE complex cooperate to trigger neurotransmitter release. Structural studies elucidated three distinct synaptotagmin-1-SNARE complex binding modes involving ‘polybasic’, ‘primary’ and ‘tripartite’ interfaces of ...
Rashmi Voleti +2 more
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Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
Nature Communications, 2019 Synaptic exocytosis depends on formation of the SNARE complex but its assembly mechanism is still under debate. Here, the authors identify an interaction between Munc13-1 and synaptobrevin-2 that is critical for the transition of the Munc18-1/syntaxin-1 ...
Shen Wang +6 more
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Identification of the SNARE complex that mediates the fusion of multivesicular bodies with the plasma membrane in exosome secretion. [PDF]
J Extracell Vesicles, 2023 Exosomes play crucial roles in local and distant cellular communication and are involved in various physiological and pathological processes. Tumour‐derived exosomes are pivotal to tumorigenesis, but the precise mechanisms underlying their secretion ...
Liu C +5 more
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Neuronal SNARE complex assembly guided by Munc18-1 and Munc13-1. [PDF]
FEBS Open Bio, 2022 Neurotransmitter release by Ca2+‐triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N‐ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin‐1, SNAP‐25, and ...
Wang S, Ma C.
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Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion. [PDF]
Autophagy, 2023 SCFD1 (sec1 family domain containing 1) was recently shown to function in autophagosome-lysosome fusion, and multiple studies have demonstrated the regulatory impacts of acetylation (a post-translational modification) on macroautophagy/autophagy.
Huang H +6 more
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Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly. [PDF]
FEBS Lett, 2021 Synaptic vesicle fusion is mediated by membrane-bridging complexes formed by SNARE proteins - VAMP2 on the vesicle and Syntaxin-1/SNAP25 on the pre-synaptic membrane.
Kalyana Sundaram RV +9 more
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Conformational change of Syntaxin-3b in regulating SNARE complex assembly in the ribbon synapses [PDF]
Scientific Reports, 2022 Neurotransmitter release of synaptic vesicles relies on the assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consisting of syntaxin and SNAP-25 on the plasma membrane and synaptobrevin on the synaptic
Claire Gething +6 more
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Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion [PDF]
Nature Communications, 2017 Membrane fusion during exocytosis is mediated by interaction between SNARE proteins on vesicles and the cell membrane, but how SNARE complex assembly is initiated remains unknown.
Peng Yue +7 more
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Rapamycin Affects the Hippocampal SNARE Complex to Alleviate Cognitive Dysfunction Induced by Surgery in Aged Rats [PDF]
Brain Sciences, 2023 Delayed neurocognitive recovery (dNCR) is a common complication that occurs post-surgery, especially in elderly individuals. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex plays an essential role in various ...
Ning Kang +8 more
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Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly. [PDF]
Mol Biol Cell, 2020 Intracellular membrane fusion requires Rab-family GTPases, their effector tethers, soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, and SNARE chaperones of the Sec1/Munc18 (SM), Sec17/α-SNAP, and Sec18/NSF families.
Torng T, Song H, Wickner W.
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