Results 21 to 30 of about 3,191 (253)

Epigallocatechin gallate inhibits SNARE‐dependent membrane fusion by blocking trans‐SNARE assembly

FEBS Open Bio, 2022
Insulin secretion is a signal‐triggered process that requires membrane fusion between the secretory granules and plasma membrane in pancreatic β cells. The exocytosis of insulin is mediated by target‐soluble N‐ethylmaleimide sensitive factor attachment ...
Min Zhu, Han Xu, Yuting Jiang, Haijia Yu, Yinghui Liu   +4 more
doaj   +1 more source

Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control

Cell Reports, 2023
Summary: The AAA+ NSF complex is responsible for SNARE complex disassembly both before and after membrane fusion. Loss of NSF function results in pronounced developmental and degenerative defects. In a genetic screen for sensory deficits in zebrafish, we
Yan Gao, Yousuf A. Khan, Weike Mo, K. Ian White, Matthew Perkins, Richard A. Pfuetzner, Josef G. Trapani, Axel T. Brunger, Teresa Nicolson   +8 more
doaj   +1 more source

Dynamic Relationship of the SNARE Complex with a Membrane [PDF]

Biophysical Journal, 2019
Fusion of secretory granules and synaptic vesicles with the plasma membrane is driven by SNARE protein interactions. Intensive investigations in vitro, which include x-ray crystallography, cryoelectron microscopy, and NMR analyses by numerous groups, have elucidated structures relevant to the function of these proteins. Although function depends on the
Ronald W, Holz, Joshua, Zimmerberg
openaire   +2 more sources

The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae [PDF]

, 2012
Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. Central to membrane trafficking is the formation of specific SNARE (soluble N-ethylmeleimide-sensitive factor attachment protein ...
Marion S Struthers, Nia J Bryant, Lindsay N Carpp, Carpp Lindsay N., Shanks, S.G., McCann Rebecca K., Carpp, L.N., Struthers, M.S., Bryant, N.J., Scott G Shanks, Struthers Marion S., McCann, R.K., Bryant Nia J., Hong, W., Shanks Scott G., Rebecca K McCann   +15 more
core   +1 more source

Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a

Cell Reports, 2015
Alzheimer’s disease (AD) is closely associated with synaptic dysfunction, and thus current treatments often aim to stimulate neurotransmission to improve cognitive impairment.
Yoosoo Yang, Jaewook Kim, Hye Yun Kim, Nayeon Ryoo, Sejin Lee, YoungSoo Kim, Hyewhon Rhim, Yeon-Kyun Shin   +7 more
doaj   +1 more source

The SNARE complex in neuronal and sensory cells [PDF]

Molecular and Cellular Neuroscience, 2012
Transmitter release at synapses ensures faithful chemical coding of information that is transmitted in the sub-second time frame. The brain, the central unit of information processing, depends upon fast communication for decision making. Neuronal and neurosensory cells are equipped with the molecular machinery that responds reliably, and with high ...
Neeliyath A, Ramakrishnan, Marian J, Drescher, Dennis G, Drescher   +2 more
openaire   +2 more sources

Mechanistic insights into the SNARE complex disassembly [PDF]

Science Advances, 2019
Near-atomic resolution structure of the 20S complex reveals the mechanism of α-SNAP mediated disassembly of the SNARE complex.
Xuan Huang, Shan Sun, Xiaojing Wang, Fenghui Fan, Qiang Zhou, Shan Lu, Yong Cao, Qiu-Wen Wang, Meng-Qiu Dong, Jun Yao, Sen-Fang Sui   +10 more
openaire   +2 more sources

The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic SNARE complexes assembly [PDF]

Journal of Cell Science, 2013
Multisubunit tethering complexes (MTCs) positively regulate vesicular fusion by as yet unclear mechanism. In this study we provide evidence that the MTC COG enhances the assembly of fusogenic Golgi SNARE complexes and concomitantly prevents nonfusogenic tSNARE interactions.
Orly Laufman, WanJin Hong, Sima Lev
openaire   +2 more sources

Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]

, 2012
Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665), Dun, Alison R., Lu, Weiping, Rory R. Duncan (120667), Weiping Lu, Gabriel J. Lord (120664), Colin Rickman (120669), Andrew Dunn, Gabriel J Lord, Martin, Kirsty J, Lei Yang (102719), Qiu, Zhen, Rickman, Colin; id_orcid, Kirsty J Martin, Lei Yang, Duncan, Rory R, Duncan, Rory R., Alison R. Dun (120660), Zhen Qiu (120662), Rickman, Colin, Dun, Alison, Qiu, Zhen; id_orcid, Colin Rickman, Rory R Duncan, Lord, Gabriel J, Kirsty J. Martin (120661), Alison R Dun, Lord, Gabriel J., Yang, Lei, Martin, Kirsty J., Andrew Dunn (120663), Dunn, Andrew, Zhen Qiu   +32 more
core   +1 more source

Complex Lipid Requirements for SNARE- and SNARE Chaperone-dependent Membrane Fusion [PDF]

Journal of Biological Chemistry, 2009
Membrane fusion without lysis has been reconstituted with purified yeast vacuolar SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors), the SNARE chaperones Sec17p/Sec18p and the multifunctional HOPS complex, which includes a subunit of the SNARE-interactive Sec1-Munc18 family, and vacuolar lipids: phosphatidylcholine (PC ...
Joji, Mima, William, Wickner
openaire   +2 more sources