VTP-Identifier: Vesicular Transport Proteins Identification Based on PSSM Profiles and XGBoost [PDF]
Frontiers in Genetics, 2022 Vesicular transport proteins are related to many human diseases, and they threaten human health when they undergo pathological changes. Protein function prediction has been one of the most in-depth topics in bioinformatics.
Yue Gong +6 more
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Computational identification of vesicular transport proteins from sequences using deep gated recurrent units architecture [PDF]
Computational and Structural Biotechnology Journal, 2019 Protein function prediction is one of the most well-studied topics, attracting attention from countless researchers in the field of computational biology. Implementing deep neural networks that help improve the prediction of protein function, however, is
Nguyen Quoc Khanh Le +4 more
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Both brefeldin A and latrunculin B treatment induces cytoplasmic aggregation of plasma membrane-associated proteins in epidermal cells, but not in columella cells [PDF]
Plant Signaling & BehaviorRoot columella and epidermal cells are crucial for sensing external stimuli, yet the differences in their plasma membrane-associated proteins' vesicular transport systems remain poorly understood.
Ai Chen, Qianqian Wang, Xianyong Sheng
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Virus infection and vesicle trafficking [PDF]
Frontiers in ImmunologyVesicle trafficking mechanisms play indispensable roles throughout the viral replication cycle, though their stage-specific regulatory mechanisms during infection require further elucidation.
Guo-Xiu Cao +5 more
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The non-vesicular cholesterol transporter GRAMD1C is a pan-coronavirus antiviral target. [PDF]
PLoS BiologyCoronaviruses (CoVs) rely heavily on host lipid metabolism for efficient replication, but the specific host pathways involved remain incompletely defined.
Zhelin Su +11 more
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Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster [PDF]
Nature Communications, 2020 Mitochondrial dynamics change during ageing, with larger mitochondria and altered protein import in older animals. Here the authors show that Dosmit protein mediates mitochondrial morphology with Rab32 by inducing double-membraned vesicles that regulate ...
Po-Lin Chen +10 more
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Vesicular Location and Transport of S100A8 and S100A9 Proteins in Monocytoid Cells.
PLoS ONE, 2015 We show here, by using surface biotinylation, followed by Western blotting or surface plasmon resonance analysis, that very low levels of S100A8 and/or S100A9 can be detected on the surface of THP-1 cells or freshly isolated human monocytes.
Paramita Chakraborty +8 more
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ASNA1 is essential for cardiac development and function by regulating tail-anchored protein stability and vesicular transport in cardiomyocytes. [PDF]
PLoS GeneticsRecent studies have linked compound heterozygous mutations in ASNA1 to progressive dilated cardiomyopathy and early infantile mortality in humans. However, the specific role of ASNA1 in cardiomyocytes and the molecular mechanisms underlying ASNA1-related
Wei Feng +8 more
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Evaluation of Hypovirus Infection on the Vesicular Protein Expression Pattern of Cryphonectria parasitica by TMT-Based Proteomics Analysis [PDF]
BiologyHypovirus infection is known to reduce the pathogenicity of Cryphonectria parasitica, the causative agent of chestnut blight. Isoforms derived from a viral protein p48 have been discovered in host mitochondria and vesicles, which may contribute to ...
Zishan Zeng +6 more
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Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum [PDF]
PeerJ, 2017 The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route.
Rahul Chaudhari +4 more
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