Results 1 to 10 of about 81,305 (152)

VTP-Identifier: Vesicular Transport Proteins Identification Based on PSSM Profiles and XGBoost [PDF]

Frontiers in Genetics, 2022
Vesicular transport proteins are related to many human diseases, and they threaten human health when they undergo pathological changes. Protein function prediction has been one of the most in-depth topics in bioinformatics.
Yue Gong, Benzhi Dong, Zixiao Zhang, Yixiao Zhai, Bo Gao, Tianjiao Zhang, Jingyu Zhang   +6 more
doaj   +7 more sources

Computational identification of vesicular transport proteins from sequences using deep gated recurrent units architecture [PDF]

Computational and Structural Biotechnology Journal, 2019
Protein function prediction is one of the most well-studied topics, attracting attention from countless researchers in the field of computational biology. Implementing deep neural networks that help improve the prediction of protein function, however, is
Nguyen Quoc Khanh Le, Edward Kien Yee Yapp, N. Nagasundaram, Matthew Chin Heng Chua, Hui-Yuan Yeh   +4 more
doaj   +4 more sources

Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster [PDF]

Nature Communications, 2020
Mitochondrial dynamics change during ageing, with larger mitochondria and altered protein import in older animals. Here the authors show that Dosmit protein mediates mitochondrial morphology with Rab32 by inducing double-membraned vesicles that regulate ...
Po-Lin Chen, Kai-Ting Huang, Chu-Ya Cheng, Jian-Chiuan Li, Hsiao-Yen Chan, Tzu-Yang Lin, Matthew P. Su, Wei-Yuan Yang, Henry C. Chang, Horng-Dar Wang, Chun-Hong Chen   +10 more
doaj   +3 more sources

Both brefeldin A and latrunculin B treatment induces cytoplasmic aggregation of plasma membrane-associated proteins in epidermal cells, but not in columella cells [PDF]

Plant Signaling & Behavior
Root columella and epidermal cells are crucial for sensing external stimuli, yet the differences in their plasma membrane-associated proteins' vesicular transport systems remain poorly understood.
Ai Chen, Qianqian Wang, Xianyong Sheng
doaj   +2 more sources

Vesicular Location and Transport of S100A8 and S100A9 Proteins in Monocytoid Cells.

PLoS ONE, 2015
We show here, by using surface biotinylation, followed by Western blotting or surface plasmon resonance analysis, that very low levels of S100A8 and/or S100A9 can be detected on the surface of THP-1 cells or freshly isolated human monocytes.
Paramita Chakraborty, Per Bjork, Eva Källberg, Anders Olsson, Matteo Riva, Matthias Mörgelin, David Liberg, Fredrik Ivars, Tomas Leanderson   +8 more
doaj   +3 more sources

The non-vesicular cholesterol transporter GRAMD1C is a pan-coronavirus antiviral target. [PDF]

PLoS Biology
Coronaviruses (CoVs) rely heavily on host lipid metabolism for efficient replication, but the specific host pathways involved remain incompletely defined.
Zhelin Su, Zhen Fu, Yichen Yang, Yanan Fu, Jingwen Mo, Juan Xu, Yubei Tan, Yixin Xiang, Yuejun Shi, Shengsong Xie, Limeng Sun, Guiqing Peng   +11 more
doaj   +2 more sources

Role of heterotrimeric GTP binding proteins in vesicular protein transport: indications for both classical and alternative G protein cycles

FEBS Letters, 1995
Heterotrimeric G proteins are involved in hormonal signal transduction across the plasma membrane. Recent evidence suggests that they have a role in vesicular protein transport as well. Biochemical probes that interfere with the classical G protein cycle have been applied to the field of intracellular membrane transport to study their mechanism of ...
J Bernd Helms
exaly   +4 more sources

ASNA1 is essential for cardiac development and function by regulating tail-anchored protein stability and vesicular transport in cardiomyocytes. [PDF]

PLoS Genetics
Recent studies have linked compound heterozygous mutations in ASNA1 to progressive dilated cardiomyopathy and early infantile mortality in humans. However, the specific role of ASNA1 in cardiomyocytes and the molecular mechanisms underlying ASNA1-related
Wei Feng, Zengming Zhang, Zeyu Chen, Li Wang, Mao Ye, Yusu Gu, Titania Huang, Harrison Ngo, Ju Chen   +8 more
doaj   +2 more sources

Membrane Trafficking Mechanisms and Their Biological Relevance [PDF]

Archives of Razi Institute, 2023
Most chemicals expressed in mammalian cells have complex delivery and transport mechanisms to get to the right intracellular sites. One of these mechanisms transports most transmembrane proteins, as well as almost all secreted proteins, from the ...
Akinwunmi Adeoye
doaj   +1 more source

Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum [PDF]

PeerJ, 2017
The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route.
Rahul Chaudhari, Vishakha Dey, Aishwarya Narayan, Shobhona Sharma, Swati Patankar   +4 more
doaj   +2 more sources