Results 41 to 50 of about 3,191 (253)
NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
eLife, 2018 SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individual ...
Ucheor B Choi +6 more
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Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]
, 2007 Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas +15 more
core +1 more source
Epileptic Phenotypes Associated With SNAREs and Related Synaptic Vesicle Exocytosis Machinery
Frontiers in Neurology, 2022 SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptor) are an heterogeneous family of proteins that, together with their key regulators, are implicated in synaptic vesicle exocytosis and synaptic transmission. SNAREs represent the
Elisa Cali +3 more
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SNARE Complex–Associated Proteins and Alcohol [PDF]
Alcoholism: Clinical and Experimental Research, 2019 Alcohol addiction causes major health problems throughout the world, causing numerous deaths and incurring a huge economic burden to society. To develop an intervention for alcohol addiction, it is necessary to identify molecular target(s) of alcohol and associated molecular mechanisms of alcohol action.
openaire +2 more sources
Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion. [PDF]
PLoS Genetics, 2018 The autophagosomal SNARE Syntaxin17 (Syx17) forms a complex with Snap29 and Vamp7/8 to promote autophagosome-lysosome fusion via multiple interactions with the tethering complex HOPS.
Szabolcs Takáts +7 more
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The destructive effect of botulinum neurotoxins on the SNARE protein: SNAP-25 and synaptic membrane fusion [PDF]
PeerJ, 2015 Synaptic exocytosis requires the assembly of syntaxin 1A and SNAP-25 on the plasma membrane and synaptobrevin 2 (VAMP2) on the vesicular membrane to bridge the two opposite membranes.
Bin Lu
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Frontiers in Molecular Neuroscience, 2017 The Ca2+ sensor synaptotagmin-1 (Syt1) plays an essential function in synaptic exocytosis. Recently, Syt1 has been implicated in synaptic vesicle priming, a maturation step prior to Ca2+-triggered membrane fusion that is believed to involve formation of ...
Yun Li +5 more
doaj +1 more source
eLife, 2016 Complexin regulates spontaneous and activates Ca2+-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformations of
Ucheor B Choi +4 more
doaj +1 more source
Energetics of (dis)assembly of the ternary SNARE complex [PDF]
Frontiers in Neuroenergetics, 2009 The soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex (Sollner et al., 1993) plays a central role in the process of exocytosis whereby vesicles fuse with the plasma membrane to release their cargo of transmitter molecules into the extracellular space.
Liu, Wei, Parpura, Vladimir
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Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP
eLife, 2019 Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle priming to a release-ready state.
Eric A Prinslow +4 more
doaj +1 more source