Results 51 to 60 of about 3,191 (253)

Rapamycin Affects the Hippocampal SNARE Complex to Alleviate Cognitive Dysfunction Induced by Surgery in Aged Rats

Brain Sciences, 2023
Delayed neurocognitive recovery (dNCR) is a common complication that occurs post-surgery, especially in elderly individuals. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex plays an essential role in various ...
Ning Kang, Xiaoguang Han, Zhengqian Li, Taotao Liu, Xinning Mi, Yue Li, Xiangyang Guo, Dengyang Han, Ning Yang   +8 more
doaj   +1 more source

SNARE complex‐mediated degranulation in mast cells [PDF]

Journal of Cellular and Molecular Medicine, 2012
Introduction SNARE function in membrane fusion events Expression of SNAREs and SNARE complexes in mast cells Functional studies implicating specific SNAREs or SNARE complexes in mast cell degranulation RNA interference studies, SNARES and mast cells Regulation of mast cell SNAREs Conclusions Mast cell function and dysregulation is important in the ...
Woska, Joseph R, Gillespie, Marc E
openaire   +2 more sources

Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion

, 2002
Characterization of mammalian NSF (G274E) and Drosophila NSF (comatose) mutants revealed an evolutionarily conserved NSF activity distinct from ATPase-dependent SNARE disassembly that was essential for Golgi membrane fusion.
Yuval Sagiv, Zvulun Elazar, Katrin Deinhardt, Richard Newman, Graham Warren, Shima, David T., Müller, Joyce M.M., Warren, Graham, David T. Shima, James Shorter, Sagiv, Yuval, Joyce M.M. Müller, Shorter, James, Newman, Richard, Elazar, Zvulun, Deinhardt, Katrin   +15 more
core   +1 more source

Mass spectrometry uncovers intermediates and off-pathway complexes for SNARE complex assembly [PDF]

, 2023
The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of ...
Hesselbarth, Julia, Schmidt, Carla
core   +2 more sources

AtNHX5 and AtNHX6 Are Required for the Subcellular Localization of the SNARE Complex That Mediates the Trafficking of Seed Storage Proteins in Arabidopsis. [PDF]

PLoS ONE, 2016
The SNARE complex composed of VAMP727, SYP22, VTI11 and SYP51 is critical for protein trafficking and PSV biogenesis in Arabidopsis. This SNARE complex directs the fusion between the prevacuolar compartment (PVC) and the vacuole, and thus mediates ...
Xuexia Wu, Kazuo Ebine, Takashi Ueda, Quan-Sheng Qiu   +3 more
doaj   +1 more source

The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity

eLife, 2021
Synaptic vesicle (SV) release probability (Pr) is a key presynaptic determinant of synaptic strength established by cell-intrinsic properties and further refined by plasticity.
Chad W Sauvola, Yulia Akbergenova, Karen L Cunningham, Nicole A Aponte-Santiago, J Troy Littleton   +4 more
doaj   +1 more source

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function

, 2011
Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles, Tebar Ramon, Francesc, Reverter Martín, Meritxell, Rentero Alfonso, Carles, Meritxell Reverter, Mulay, Vishwaroop, Peta Wood, Vilà de Muga, Sandra, Álvarez-Guaita, Anna, Anna Alvarez-Guaita, Albert Pol, Francesc Tebar, Carlos Enrich, Cairns, Rose, Joan Blasi, Blasi Cabús, Joan, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood, Peta, Katia Monastyrskaya, Grewal, Thomas, Pol i Sorolla, Albert, Thomas Grewal, Monastyrskaya, Katia, Sandra Vilà de Muga   +25 more
core   +1 more source

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

eLife, 2018
Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zippering of ...
Junyi Jiao, Mengze He, Sarah A Port, Richard W Baker, Yonggang Xu, Hong Qu, Yujian Xiong, Yukun Wang, Huaizhou Jin, Travis J Eisemann, Frederick M Hughson, Yongli Zhang   +11 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

SNARE Complex Structure and Dynamics.

, 2022
(A) SNAREpins prior to vesicle fusion. (B) Binding of Ca2+ to synaptotagmin (Syt-1 here, Syt-7 attaches to target membrane [6,7]) triggers full zippering of SNARE complex and, in turn, vesicle fusion [8,9].
Jonathan W. Garcia (12519618), Thomas M. Bartol (8174295), Terrence J. Sejnowski (8174298)   +2 more
core   +1 more source