Results 101 to 110 of about 73,344 (342)

Double Knockout of Munc18b and Munc18c Reduces Translocation of GLUT4 in Response to Insulin [PDF]

, 2016
Insulin resistance has become a prominent issue in the United States, causing serious comorbid conditions. One crucial step in insulin response in adipose and muscle tissue is the movement of glucose transporter GLUT4 to the cell surface from storage ...
Praggastis, Zoe A
core   +2 more sources

Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement [PDF]

, 2017
The current model for vesicular traffic to and from the plasma membrane is accepted but the molecular requirements for this coordination are not well defined.
Blatt, Michael R., Larson, Emily R., Marion-Poll, Annie, Roux, Camille, Van Zelm, Eva   +4 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

eLife, 2015
Synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins couple their stage-wise folding/assembly to rapid exocytosis of neurotransmitters in a Munc18-1-dependent manner.
Lu Ma, Aleksander A Rebane, Guangcan Yang, Zhiqun Xi, Yuhao Kang, Ying Gao, Yongli Zhang   +6 more
doaj   +1 more source

Alternate routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4 [PDF]

, 2015
Insulin-stimulated delivery of glucose transporters (GLUT4) from specialized intracellular GLUT4 storage vesicles (GSVs) to the surface of fat and muscle cells is central to whole-body glucose.
Bryant, Nia J., Gould, Gwyn W., Kioumourtzoglou, Dimitrios, Pryor, Paul R.   +3 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Nature Communications, 2020
Vesicle associated membrane protein 2 (VAMP2) contains a conserved SNARE motif that interacts with syntaxin-1 and SNAP25 for SNARE complex assembly. Here authors use in-cell NMR spectroscopy to describe the dynamic membrane association of VAMP2 SNARE ...
Chuchu Wang, Jia Tu, Shengnan Zhang, Bin Cai, Zhenying Liu, Shouqiao Hou, Qinglu Zhong, Xiao Hu, Wenbin Liu, Guohui Li, Zhijun Liu, Lin He, Jiajie Diao, Zheng-Jiang Zhu, Dan Li, Cong Liu   +15 more
doaj   +1 more source

An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]

, 2003
The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B., Knopf, Lea G., Li, Yajie, Marti, Matthias, Müller, Norbert, Regös, Attila, Schraner, Elisabeth M., Wild, Peter   +7 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex

Molecular Biology of the Cell, 2012
Soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins catalyze membrane fusion events in the secretory and endolysosomal systems, and all SNARE-mediated fusion processes require cofactors of the Sec1/Munc18 (SM) family. Vps33 is an SM protein and subunit of the Vps-C complexes HOPS (homotypic fusion and protein sorting)
Lobingier, Braden T., Merz, Alexey J.
openaire   +2 more sources