Results 121 to 130 of about 73,344 (342)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion [PDF]

, 2017
Neurotransmission and secretion of hormones involve a sequence of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane.
A Flašker, A Ruiz, B Balatoni, B Czech, B Davletov, B Rituper, BA Davletov, C Rickman, C Wu, CA Foster, CF Brosnan, D Marsolais, E Connell, E Connell, E Neher, ET Kavalali, ET Kavalali, EV Mosharov, F Darios, F Safarian, J Vargas-Medrano, K Chiba, K Hu, KL Arendt, L Svennerholm, LM Gutierrez, M Holt, M Rupnik, M Schröder, M Stenovec, MD Ward, N Takasugi, N Vardjan, NC Hait, P O’Connor, R Brunkhorst, R Cipriani, R Deogracias, RM Wightman, S Jurado, S Lipovšek, S Rossi, S Trkov, V Brinkmann, V García-Martínez, V García-Martínez, VT Cruz, X He, Y Wei, YA Hannun, YD Fragoso   +50 more
core   +4 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. [PDF]

, 1998
We have investigated the controversial involvement of components of the SNARE (soluble N-ethyl maleimide-sensitive factor [NSF] attachment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polarized epithelial (MDCK)
Chapin, SJ, Kömüves, LG, Low, SH, Mostov, KE, Weimbs, T, Whiteheart, SW, Wimmer, C   +6 more
core  

Synchronizing Sequencing Software to a Live Drummer [PDF]

, 2013
Copyright 2013 Massachusetts Institute of Technology. MIT allows authors to archive published versions of their articles after an embargo period. The article is available at
Andrew Robertson, Bello J. P., Brossier P. M., Dannenberg R. B., Eck D., Freeman P., Goto M., Lago N. P., Large E. W., Mark D. Plumbley, Puckette M., Robertson A., Robertson A., Robertson A., Robertson A., Stark A. M., Stark A. M.   +16 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor-Derived Peptides for Regulation of Mast Cell Degranulation

Frontiers in Immunology, 2018
Vesicle-associated V-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins and target membrane-associated T-SNAREs (syntaxin 4 and SNAP-23) assemble into a core trans-SNARE complex that mediates membrane fusion during ...
Yoosoo Yang, Yoosoo Yang, Byoungjae Kong, Byoungjae Kong, Younghoon Jung, Younghoon Jung, Joon-Bum Park, Joon-Bum Park, Jung-Mi Oh, Jaesung Hwang, Jae Youl Cho, Jae Youl Cho, Dae-Hyuk Kweon, Dae-Hyuk Kweon   +13 more
doaj   +1 more source

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. [PDF]

, 2015
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Corbett, Kevin D, Moeller, Arne, Rosenberg, Scott C, Speir, Jeffrey A, Su, Tiffany Y, Ye, Qiaozhen   +5 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source