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Molecular Dynamics Simulations of the SNARE Complex

2018
Molecular dynamics (MD) simulations enable in silico investigations of the dynamic behavior of proteins and protein complexes. Here, we describe MD simulations of the SNARE complex and its interactions with the neuronal protein complexin. Complexin is an effector of neuronal secretion that inhibits spontaneous fusion and is thought to clamp the fusion ...
openaire   +2 more sources

Studies of the regulated assembly of SNARE complexes in adipocytes

Biochemical Society Transactions, 2014
Insulin plays a fundamental role in whole-body glucose homeostasis. Central to this is the hormone's ability to rapidly stimulate the rate of glucose transport into adipocytes and muscle cells [1]. Upon binding its receptor, insulin stimulates an intracellular signalling cascade that culminates in redistribution of glucose transporter proteins ...
Dimitrios, Kioumourtzoglou   +6 more
openaire   +2 more sources

Mechanisms of SNARE proteins in membrane fusion

Nature Reviews Molecular Cell Biology, 2023
Reinhard Jahn   +2 more
exaly  

SNARE the rod, coil the complex

Nature, 1998
William I. Weis, Richard H. Scheller
openaire   +1 more source

Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex

Proceedings of the National Academy of Sciences of the United States of America, 2020
Tong Shu   +2 more
exaly  

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