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Molecular Dynamics Simulations of the SNARE Complex
2018Molecular dynamics (MD) simulations enable in silico investigations of the dynamic behavior of proteins and protein complexes. Here, we describe MD simulations of the SNARE complex and its interactions with the neuronal protein complexin. Complexin is an effector of neuronal secretion that inhibits spontaneous fusion and is thought to clamp the fusion ...
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Studies of the regulated assembly of SNARE complexes in adipocytes
Biochemical Society Transactions, 2014Insulin plays a fundamental role in whole-body glucose homeostasis. Central to this is the hormone's ability to rapidly stimulate the rate of glucose transport into adipocytes and muscle cells [1]. Upon binding its receptor, insulin stimulates an intracellular signalling cascade that culminates in redistribution of glucose transporter proteins ...
Dimitrios, Kioumourtzoglou +6 more
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Mechanisms of SNARE proteins in membrane fusion
Nature Reviews Molecular Cell Biology, 2023Reinhard Jahn +2 more
exaly
SNARE the rod, coil the complex
Nature, 1998William I. Weis, Richard H. Scheller
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Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly
EMBO Journal, 2020Jihong Gong, Le Zhu, Shen Wang
exaly
Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex
Proceedings of the National Academy of Sciences of the United States of America, 2020Tong Shu +2 more
exaly

