Results 41 to 50 of about 44,845 (236)

GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins

open access: yesFrontiers in Cell and Developmental Biology, 2022
Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate defects
Amrita Khakurel   +4 more
doaj   +1 more source

Regulation of plasma membrane expansion during axon formation [PDF]

open access: yes, 2018
Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano   +2 more
core   +1 more source

Numerical Experiments with Coupled Membranes and the Snare Mechanism [PDF]

open access: yes, 2010
National audienceThe snare drum is one of the more complex musical instruments from a modeling and synthesis perspective---it includes elements modeled as 0D (the drum stick), 1D (the snares), 2D (a pair of membranes) and 3D (the cavity and perhaps the ...
Bilbao, Stefan
core   +1 more source

Alternate routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4 [PDF]

open access: yes, 2015
Insulin-stimulated delivery of glucose transporters (GLUT4) from specialized intracellular GLUT4 storage vesicles (GSVs) to the surface of fat and muscle cells is central to whole-body glucose.
Bryant, Nia J.   +3 more
core   +3 more sources

Animal moral psychologies [PDF]

open access: yes, 2022
Observations of animals engaging in apparently moral behavior have led academics and the public alike to ask whether morality is shared between humans and other animals.
Andrews, Kristin, Monsó, Susana
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Selectivity and injury risk in an improved neck snare for live‐capture of foxes

open access: yesWildlife Society Bulletin, 2012
Neck snares have been considered valuable for the control of canids and to catch canids for scientific purposes, but they have been criticized for perceived low target selectivity and poor animal‐welfare. In 2006, we designed an experimental passive neck
Mike J. Short   +3 more
doaj   +1 more source

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]

open access: yes, 2006
Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium.
A. Scheuber   +32 more
core   +6 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

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