Results 81 to 90 of about 15,243 (207)

SNOntology: Myriads of novel snornas or just a mirage?

BMC Genomics, 2011
Background Small nucleolar RNAs (snoRNAs) are a large group of non-coding RNAs (ncRNAs) that mainly guide 2'-O-methylation (C/D RNAs) and pseudouridylation (H/ACA RNAs) of ribosomal RNAs.
Makarova Julia A, Kramerov Dmitri A
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Saturated Fatty Acids and snoRNAs: Partners in Crime [PDF]

Cell Metabolism, 2011
Lipotoxicity describes the process of cellular dysfunction in response to lipid overload. In this issue of Cell Metabolism, Michel and colleagues (2011) provide evidence for a role of snoRNAs in palmitate-induced oxidative stress.
Mattijssen, F.B.J., Kersten, A.H.
openaire   +3 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie, Shan Jin, Yao Zhan, Tiantian Du, Yaqi Dong, Peilong Li, Xiaoshi Zhang, Qiuchen Qi, Jie Gao, Chuanxin Wang   +9 more
wiley   +1 more source

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors [PDF]

Molecular Biology of the Cell, 2010
Human small nucleolar RNAs (snoRNAs) that copurify with nucleoli isolated from HeLa cells have been characterized. Novel fibrillarin-associated snoRNAs were detected that allowed the creation of a new vector system for the targeted knockdown of one or more genes in mammalian cells.
Ono, Motoharu, Yamada, Kayo, Avolio, Fabio, Scott, Michelle S., van Koningsbruggen, Silvana, Barton, Geoffrey J., Lamond, Angus I.   +6 more
openaire   +3 more sources

The impact of scaRNA12 deregulation on p53‐mediated cellular stress response in B‐cell precursor acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Summary Small nucleolar ribonucleic acids (snoRNAs) are a class of small non‐coding RNAs involved in the post‐transcriptional modification of ribosomal RNAs (rRNA) and small nuclear RNAs (snRNA). Mounting evidence indicates that specific snoRNAs are drivers of oncogenesis, but their role in B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) is ...
Martijn W. C. Verbeek, Mathijs A. Sanders, Dwin G. B. Grashof, Remco M. Hoogenboezem, Iris van Zuijen, Annemarieke Bos, Trui van Gulck, Rosan Olsman, Rishov Mukhopadhyay, Eric M. J. Bindels, Peter J. M. Valk, Harmen J. G. van de Werken, Vincent H. J. van der Velden, Stefan J. Erkeland   +13 more
wiley   +1 more source

Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing [PDF]

Genome Biology, 2013
Abstract Background In recent years, a variety of small RNAs derived from other RNAs with well-known functions such as tRNAs and snoRNAs, have been identified. The functional relevance of these RNAs is largely unknown.
Kishore, Shivendra, Gruber, Andreas R., Jedlinski, Dominik J., Syed, Afzal P., Jorjani, Hadi, Zavolan, Mihaela   +5 more
openaire   +3 more sources

Strain, procedures, and tools for reproducible genetic transformation and genome editing of the emerging plant model Spirodela polyrhiza

New Phytologist, EarlyView.
Summary Duckweeds (Lemnaceae) have excellent potential for fundamental and applied research due to ease of cultivation, small size, and continuous fast clonal growth. However, their usage as model organisms and platforms for biotechnological applications is often limited by the lack of universal genetic manipulation methods necessary for transgene ...
Verónica Barragán‐Borrero, Amanda de Santana Lopes, Enrico Diniz Rodrigues Batista, Martin Höfer, Rana Elias, Abhisek Chakraborty, Arturo Ponce‐Mañe, Clotilde Descombes, Laura Diezma‐Navas, Lydia Petraki, Meret Huber, Shuqing Xu, Arturo Marí‐Ordóñez   +12 more
wiley   +1 more source

SnoReport: computational identification of snoRNAs with unknown targets [PDF]

Bioinformatics, 2007
AbstractSummary: Unlike tRNAs and microRNAs, both classes of snoRNAs, which direct two distinct types of chemical modifications of uracil residues, have proved to be surprisingly difficult to find in genomic sequences. Most computational approaches so far have explicitly used the fact that snoRNAs predominantly target ribosomal RNAs and spliceosomal ...
Hertel, Jana, Hofacker, Ivo L., Stadler, Peter F.   +2 more
openaire   +4 more sources