Results 81 to 90 of about 14,550 (176)

A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

Aging Cell, Volume 25, Issue 4, April 2026.
The disruption of a cluster of three snoRNAs in the epithelium of the gut deregulates the lipid and sterol (including the cholesterol) homeostasis. At the whole‐organism level, this chronic deregulation, all along life, decreases lifespan and leads to neurodegenerative lesions in old flies.
Sara Al Issa, Théo Gauvrit, Patricia Daira, Nathalie Bernoud‐Hubac, Jean‐René Martin   +4 more
wiley   +1 more source

Serum‐Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults

Aging Cell, Volume 25, Issue 4, April 2026.
We show unique signatures of small noncoding RNA cargos and mitochondrial proteins in serum EVs and muscle‐derived EVs associated with age‐related mobility resilience. These findings suggest a role for serum EVs in mediating molecular communication related to functional aging phenotypes and underscore the potential of EV biomarkers.
Nicholas F. Fitz, Ashish Kumar, Yixin Su, Mitu Sharma, Sangeeta Singh, Radosveta Koldamova, Iliya Lefterov, Amrita Sahu, Fabrisia Ambrosio, Caterina Rosano, Gagan Deep   +10 more
wiley   +1 more source

Strain, procedures, and tools for reproducible genetic transformation and genome editing of the emerging plant model Spirodela polyrhiza

New Phytologist, Volume 250, Issue 2, Page 735-756, April 2026.
Summary Duckweeds (Lemnaceae) have excellent potential for fundamental and applied research due to ease of cultivation, small size, and continuous fast clonal growth. However, their usage as model organisms and platforms for biotechnological applications is often limited by the lack of universal genetic manipulation methods necessary for transgene ...
Verónica Barragán‐Borrero, Amanda de Santana Lopes, Enrico Diniz Rodrigues Batista, Martin Höfer, Rana Elias, Abhisek Chakraborty, Arturo Ponce‐Mañe, Clotilde Descombes, Laura Diezma‐Navas, Lydia Petraki, Meret Huber, Shuqing Xu, Arturo Marí‐Ordóñez   +12 more
wiley   +1 more source

Identification of Eight Small Nucleolar RNAs as Survival Biomarkers and Their Clinical Significance in Gastric Cancer

Frontiers in Oncology, 2019
Gastric cancer is one of most common cancers worldwide. Studies have shown that small nucleolar RNAs (snoRNAs) play important roles in several cancers. In this study, we analyzed the snoRNAs that were differentially expressed between gastric tumors and ...
Xuning Wang, Maolin Xu, Yongfeng Yan, Yanshen Kuang, Peng Li, Wei Zheng, Hongyi Liu, Baoqing Jia   +7 more
doaj   +1 more source

snoRNA box C/D levels in leukemia cells in chromosomal abnormalities after irradiation

Сибирский онкологический журнал
The study objective. This paper reviews the express of C/D box snoRNAs (small nucleolar RNAs) and possibility of their use as biomarkers of radioresistance in chromosomal abnormalities. Material and Methods.
E. V. Rastorgueva, E. S. Pogodina, E. V. Iurova, E. A. Beloborodov, D. E. Sugak, I. A. Tumozov, Yu. V. Saenko, A. Ni. Fomin   +7 more
doaj   +1 more source

SnoRNAs: Exploring Their Implication in Human Diseases

International Journal of Molecular Sciences
Small nucleolar RNAs (snoRNAs) are earning increasing attention from research communities due to their critical role in the post-transcriptional modification of various RNAs. These snoRNAs, along with their associated proteins, are crucial in regulating the expression of a vast array of genes in different human diseases.
Waseem Chauhan, null Sudharshan SJ, Sweta Kafle, Rahima Zennadi   +3 more
openaire   +2 more sources

Cl gene cluster encoding several small nucleolar RNAs: a comparison amongst trypanosomatids

Memorias do Instituto Oswaldo Cruz, 2009
Small nucleolar RNAs (snoRNAs) are small non-coding RNAs that modify RNA molecules such as rRNA and snRNA by guiding 2'-O-ribose methylation (C/D box snoRNA family) and pseudouridylation reactions (H/ACA snoRNA family). H/ACA snoRNAs are also involved in
Paola Nocua, Carolina Gómez, Claudia Cuervo, Concepción Puerta   +3 more
doaj   +1 more source

Eukaryotic snoRNAs: A paradigm for gene expression flexibility

Genomics, 2009
Small nucleolar RNAs (snoRNAs) are one of the most ancient and numerous families of non-protein-coding RNAs (ncRNAs). The main function of snoRNAs - to guide site-specific rRNA modification - is the same in Archaea and all eukaryotic lineages. In contrast, as revealed by recent genomic and RNomic studies, their genomic organization and expression ...
DIECI, Giorgio, MONTANINI, Barbara, PRETI M   +2 more
openaire   +3 more sources

Guide snoRNAs: Drivers or Passengers in Human Disease?

Biology, 2018
In every domain of life, RNA-protein interactions play a significant role in co- and post-transcriptional modifications and mRNA translation. RNA performs diverse roles inside the cell, and therefore any aberrancy in their function can cause various ...
Manisha Deogharia, Mrinmoyee Majumder
doaj   +1 more source

SnoRNAs in cardiovascular development, function, and disease

Trends in Molecular Medicine
Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI ...
Alzbeta Chabronova, Terri L. Holmes, Duc M. Hoang, Chris Denning, Victoria James, James G.W. Smith, Mandy J. Peffers   +6 more
openaire   +3 more sources