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SNP-CRISPR: A Web Tool for SNP-Specific Genome Editing [PDF]
G3 Genes|Genomes|Genetics, 2019 CRISPR-Cas9 is a powerful genome editing technology in which a single guide RNA (sgRNA) confers target site specificity to achieve Cas9-mediated genome editing.
Chiao-Lin Chen +6 more
semanticscholar +6 more sources
A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data [PDF]
Bioinform., 2011 MOTIVATION Most existing methods for DNA sequence analysis rely on accurate sequences or genotypes. However, in applications of the next-generation sequencing (NGS), accurate genotypes may not be easily obtained (e.g. multi-sample low-coverage sequencing
Heng Li
semanticscholar +1 more source
Clinical Significance and Management of Hyponatremia in Liver Cirrhosis
Gastroenterology Insights, 2023 The overall prevalence of hyponatremia in cirrhotics is around 50%. Hypovolemic hyponatremia is a result of excessive fluid loss caused mostly by diuretic treatment or diarrhea.
Martin Janičko +6 more
doaj +1 more source
Multiple Testing for SNP-SNP Interactions [PDF]
Statistical Applications in Genetics and Molecular Biology, 2007 Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction patterns given as expressions linked by logical operators.
S Weidinger +4 more
openaire +3 more sources
Selected In Situ Hybridization Methods: Principles and Application
Molecules, 2021 We are experiencing rapid progress in all types of imaging techniques used in the detection of various numbers and types of mutation. In situ hybridization (ISH) is the primary technique for the discovery of mutation agents, which are presented in a ...
Dominika Veselinyová +5 more
doaj +1 more source
SNP-Flankplus: SNP ID-centric retrieval for SNP flanking sequences [PDF]
Bioinformation, 2008 The flanking sequences provided by dbSNP of NCBI are usually short and fixed length without further extension, thus making the design of appropriate PCR primers difficult. Here, we introduce a tool named "SNP-Flankplus" to provide a web environment for retrieval of SNP flanking sequences from both the dbSNP and the nucleotide databases of NCBI. Two SNP
Li-Yeh Chuang +3 more
openaire +3 more sources
SNP-VISTA: An interactive SNP visualization tool [PDF]
BMC Bioinformatics, 2005 Abstract Background Recent advances in sequencing technologies promise to provide a better understanding of the genetics of human disease as well as the evolution of microbial populations. Single Nucleotide Polymorphisms (SNPs) are established genetic markers that aid in the identification of loci affecting quantitative ...
Inna Dubchak +10 more
openaire +5 more sources
SNP by SNP by environment interaction network of alcoholism [PDF]
BMC Systems Biology, 2017 Alcoholism has a strong genetic component. Twin studies have demonstrated the heritability of a large proportion of phenotypic variance of alcoholism ranging from 50-80%. The search for genetic variants associated with this complex behavior has epitomized sequence-based studies for nearly a decade. The limited success of genome-wide association studies
Gil Alterovitz +3 more
openaire +3 more sources
SNP+ to predict dropout rates in SNP arrays
Conservation Genetics Resources, 2022 AbstractGenotyping individuals using forensic or non-invasive samples such as hair or fecal samples increases the risk of allelic amplification failure (dropout) due to the low quality and quantity of DNA. One way to decrease genotyping errors is to increase the number of replicates per sample.
Sastre Alaiz, Natalia +2 more
openaire +2 more sources