Results 31 to 40 of about 510,619 (336)

Fast and SNP-tolerant detection of complex variants and splicing in short reads

Bioinform., 2010
Motivation: Next-generation sequencing captures sequence differences in reads relative to a reference genome or transcriptome, including splicing events and complex variants involving multiple mismatches and long indels.
Thomas D. Wu, Serban Nacu
semanticscholar   +1 more source

A new SNP genotyping technology Target SNP-seq and its application in genetic analysis of cucumber varieties

Scientific Reports, 2020
To facilitate the utility of SNP-based genotyping, we developed a new method called target SNP-seq which combines the advantages of multiplex PCR amplification and high throughput sequencing.
Jian Zhang, Jingjing Yang, Like Zhang, Jiang Luo, Hong Zhao, Jianan Zhang, Changlong Wen   +6 more
semanticscholar   +1 more source

Robust Demographic Inference from Genomic and SNP Data

PLoS Genetics, 2013
We introduce a flexible and robust simulation-based framework to infer demographic parameters from the site frequency spectrum (SFS) computed on large genomic datasets.
L. Excoffier, I. Dupanloup, E. Huerta-Sánchez, V. Sousa, M. Foll   +4 more
semanticscholar   +1 more source

Influence of Kartogenin on Chondrogenic Differentiation of Human Bone Marrow-Derived MSCs in 2D Culture and in Co-Cultivation with OA Osteochondral Explant

Molecules, 2018
Articular cartilage has limited capacity for natural regeneration and repair. In the present study, we evaluated kartogenin (KGN), a bioactive small heterocyclic molecule, for its effect on in vitro proliferation and chondrogenic differentiation of human
Timea Spakova, Jana Plsikova, Denisa Harvanova, Marek Lacko, Stefan Stolfa, Jan Rosocha   +5 more
doaj   +1 more source

SNPsyn: detection and exploration of SNP–SNP interactions [PDF]

Nucleic Acids Research, 2011
SNPsyn (http://snpsyn.biolab.si) is an interactive software tool for the discovery of synergistic pairs of single nucleotide polymorphisms (SNPs) from large genome-wide case-control association studies (GWAS) data on complex diseases. Synergy among SNPs is estimated using an information-theoretic approach called interaction analysis.
Curk, Tomaz, Rot, Gregor, Zupan, Blaz
openaire   +3 more sources

Optimisation of urine sample preparation for shotgun proteomics

Open Chemistry, 2020
Urine reflects the renal function and urinary and kidney systems, but it may also reflect the presence of cancer in other parts of the body. Urine also has potential for providing prognostic information during therapeutic treatments thanks to non ...
Tkáčiková Soňa, Talian Ivan, Sabo Ján   +2 more
doaj   +1 more source

PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data.

Genome Research, 2007
Comprehensive identification and cataloging of copy number variations (CNVs) is required to provide a complete view of human genetic variation. The resolution of CNV detection in previous experimental designs has been limited to tens or hundreds of ...
Kai Wang, Mingyao Li, D. Hadley, Rui Liu, J. Glessner, S. Grant, H. Hakonarson, M. Bucan   +7 more
semanticscholar   +1 more source

The Importance of Natural Antioxidants in Female Reproduction

Antioxidants, 2023
Oxidative stress (OS) has an important role in female reproduction, whether it is ovulation, endometrium decidualization, menstruation, oocyte fertilization, or development andimplantation of an embryo in the uterus.
Janka Vašková, Zuzana Klepcová, Ivana Špaková, Peter Urdzík, Jana Štofilová, Izabela Bertková, Marek Kľoc, Miroslava Rabajdová   +7 more
doaj   +1 more source

fastSTRUCTURE: Variational Inference of Population Structure in Large SNP Data Sets

Genetics, 2014
Tools for estimating population structure from genetic data are now used in a wide variety of applications in population genetics. However, inferring population structure in large modern data sets imposes severe computational challenges. Here, we develop
Anil Raj, M. Stephens, J. Pritchard
semanticscholar   +1 more source

Posición sobre los componentes del sistema de evaluación, a propósito del área de lenguaje

Enunciación, 1996
                                                                                                                                      
Patricia Duarte A., Carlos Ordoñez P., Miralba Correa R., Gloria Rincón B., Neyla Pardo A., Fabio Jurado V., Guillermo Bustamante Z., Daniel Hernández R.   +7 more
doaj   +1 more source